Criteria for endocrine disrupters: report from the Danish centre on Endocrine Disrupters (CEHOS)

The aim of this session is to give a presentation of the report (both ENV and HH) on criteria carried out by the Danish Centre on Endocrine Disrupters (CEHOS) as a project
contracted by the Danish Environmental Protection Agency. CEHOS is an interdisciplinary scientific network without walls and the main purpose of the Centre is to build
and gather new knowledge on endocrine disrupters (EDs) with focus on information needed for the preventive work of the regulatory authorities. The aim of the report was
to propose scientific criteria for the identification of ED substances of concern for human health and the environment. A number of issues relevant for the development of
criteria for EDs were considered such as definition, potency, lead effects, specificity and relevance for humans and the environment.
The proposed criteria divide substances into three categories dependent on the available data: 1. Confirmed ED, 2a. Suspected ED and 2b. Indicated ED. The report describes
the scientific evidence needed for fulfilling these criteria based on the OECD Conceptual Framework for endocrine testing and assessment. It considers non-test methods, test
methods, epidemiology and field studies and gives examples of available ED data and relevant placement in groups. The overall purpose of the report is to provide scientific
background for Danish input to the ongoing EU work within this field.