Creatine kinase response to high-intensity aerobic exercise in adult-onset muscular dystrophy

Søren P Andersen, Marie Louise Sveen, Regitze S Hansen, Karen L Madsen, Jonas B Hansen, Mads Madsen, John Vissing

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

INTRODUCTION: We investigated the effect of high-intensity exercise on plasma creatine kinase (CK) in patients with muscular dystrophies.

METHODS: Fourteen patients with Becker (BMD), facioscapulohumeral (FSHD), or limb-girdle type 2 (LGMD2) muscular dystrophy, and 8 healthy subjects performed 5 cycling tests: an incremental max test, and tests at 65%, 75%, 85%, and 95% of maximal oxygen uptake (VO2max ). Heart rate and oxygen consumption were measured during the tests, and plasma CK was measured before, immediately after, and 24 hours after exercise.

RESULTS: All subjects were able to perform high-intensity exercise at the different levels. In patients with LGMD2 and FSHD, CK normalized 24 hours after exercise compared with the pre-exercise value, whereas those with BMD and healthy controls had elevated CK values 24 hours after exercise.

CONCLUSIONS: The findings suggest that high-intensity exercise is generally well tolerated in patients with LGMD2 and FSHD, whereas those with BMD may be more prone to exercise-induced damage.

OriginalsprogEngelsk
TidsskriftMuscle & Nerve
Vol/bind48
Udgave nummer6
Sider (fra-til)897-901
ISSN0148-639X
DOI
StatusUdgivet - dec. 2013
Udgivet eksterntJa

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