Course of contact allergy in consecutive eczema patients patch tested with TRUE Test panels 1 and 2 at least twice over a 12-year period

Charlotte D Jensen, Klaus E Andersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2005-May
OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind52
Udgave nummer5
Sider (fra-til)242-6
Antal sider4
ISSN0105-1873
DOI
StatusUdgivet - 1. maj 2005

Fingeraftryk

Patch Tests
Eczema
Hypersensitivity
Dermatitis
Reading
Retrospective Studies
Skin

Citer dette

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title = "Course of contact allergy in consecutive eczema patients patch tested with TRUE Test panels 1 and 2 at least twice over a 12-year period",
abstract = "Non-reproducibility of positive patch test reactions is common. In this retrospective study, we investigated the reproducibility of previously positive patch test reactions and the appearance of new positive reactions in a consecutive series of 264 eczema patients tested at least twice over a 12-year period using the TRUE Test standardized patch test system. Out of 297 positive reactions, 66{\%} remained positive in a 2nd test, 10{\%} were scored as doubtful and 24{\%} as negative. Among the previously recorded doubtful reactions, 13{\%} were positive in the 2nd test, 13{\%} were again doubtful and 74{\%} negative. In relation to the degree of patch test reactivity, 48{\%} of the + reactions were reproducible, compared to 87{\%} of ++ and +++ reactions. No difference in reproducibility was observed between patients tested with a short or a long-time interval between tests. With the use of the TRUE Test panels 1 and 2, methodological factors are minimized. The variation in patch test positivity may then be attributed to biological variation, which depends on several individual factors such as patch test reading, patient-related factors such as changed immunological sensitivity, regional variation of the skin on the back and the presence of more or less active dermatitis.",
keywords = "Allergens, Cohort Studies, Dermatitis, Allergic Contact, Eczema, Female, Humans, Male, Patch Tests, Recurrence, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Time Factors",
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Course of contact allergy in consecutive eczema patients patch tested with TRUE Test panels 1 and 2 at least twice over a 12-year period. / Jensen, Charlotte D; Andersen, Klaus E.

I: Contact Dermatitis, Bind 52, Nr. 5, 01.05.2005, s. 242-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Course of contact allergy in consecutive eczema patients patch tested with TRUE Test panels 1 and 2 at least twice over a 12-year period

AU - Jensen, Charlotte D

AU - Andersen, Klaus E

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Non-reproducibility of positive patch test reactions is common. In this retrospective study, we investigated the reproducibility of previously positive patch test reactions and the appearance of new positive reactions in a consecutive series of 264 eczema patients tested at least twice over a 12-year period using the TRUE Test standardized patch test system. Out of 297 positive reactions, 66% remained positive in a 2nd test, 10% were scored as doubtful and 24% as negative. Among the previously recorded doubtful reactions, 13% were positive in the 2nd test, 13% were again doubtful and 74% negative. In relation to the degree of patch test reactivity, 48% of the + reactions were reproducible, compared to 87% of ++ and +++ reactions. No difference in reproducibility was observed between patients tested with a short or a long-time interval between tests. With the use of the TRUE Test panels 1 and 2, methodological factors are minimized. The variation in patch test positivity may then be attributed to biological variation, which depends on several individual factors such as patch test reading, patient-related factors such as changed immunological sensitivity, regional variation of the skin on the back and the presence of more or less active dermatitis.

AB - Non-reproducibility of positive patch test reactions is common. In this retrospective study, we investigated the reproducibility of previously positive patch test reactions and the appearance of new positive reactions in a consecutive series of 264 eczema patients tested at least twice over a 12-year period using the TRUE Test standardized patch test system. Out of 297 positive reactions, 66% remained positive in a 2nd test, 10% were scored as doubtful and 24% as negative. Among the previously recorded doubtful reactions, 13% were positive in the 2nd test, 13% were again doubtful and 74% negative. In relation to the degree of patch test reactivity, 48% of the + reactions were reproducible, compared to 87% of ++ and +++ reactions. No difference in reproducibility was observed between patients tested with a short or a long-time interval between tests. With the use of the TRUE Test panels 1 and 2, methodological factors are minimized. The variation in patch test positivity may then be attributed to biological variation, which depends on several individual factors such as patch test reading, patient-related factors such as changed immunological sensitivity, regional variation of the skin on the back and the presence of more or less active dermatitis.

KW - Allergens

KW - Cohort Studies

KW - Dermatitis, Allergic Contact

KW - Eczema

KW - Female

KW - Humans

KW - Male

KW - Patch Tests

KW - Recurrence

KW - Reproducibility of Results

KW - Retrospective Studies

KW - Sensitivity and Specificity

KW - Time Factors

U2 - 10.1111/j.0105-1873.2005.00555.x

DO - 10.1111/j.0105-1873.2005.00555.x

M3 - Journal article

VL - 52

SP - 242

EP - 246

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 5

ER -