Cost-effectiveness of a transdiagnostic psychotherapy program for youth with common mental health problems

Rasmus Trap Wolf*, Pia Jeppesen, Mette Maria Agner Pedersen, Louise Berg Puggaard, Mikael Thastum, Niels Bilenberg, Per Hove Thomsen, Wendy K. Silverman, Kerstin Jessica Plessen, Simon Peter Neumer, Christoph U. Correll, Anne Katrine Pagsberg, Dorte Gyrd-Hansen


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Objectives: Our objective was to evaluate the cost-effectiveness of the transdiagnostic psychotherapy program Mind My Mind (MMM) for youth with common mental health problems using a cost-utility analysis (CUA) framework and data from a randomized controlled trial. Furthermore, we analyzed the impact of the choice of informant for both quality-of-life reporting and preference weights on the Incremental Cost-Effectiveness Ratio (ICER). Methods: A total of 396 school-aged (6–16 years) youth took part in the 6-month trial carried out in Denmark. CUAs were carried out for the trial period and four one-year extrapolation scenarios. Costs were based on a combination of budget and self-reported costs. Youths and parents were asked to report on the youth’s quality-of-life three times during the trial using the Child Health Utility 9D (CHU9D). Parental-reported CHU9D was used in the base case together with preference weights of a youth population. Analyses using self-reported CHU9D and preference weights of an adult population were also carried out. Results: The analysis of the trial period resulted in an ICER of €170,465. The analyses of the one-year scenarios resulted in ICERs between €23,653 and €50,480. The ICER increased by 24% and 71% compared to the base case when using self-reported CHU9D and adult preference weights, respectively. Conclusion: The MMM intervention has the potential to be cost-effective, but the ICER is dependent on the duration of the treatment effects. Results varied significantly with the choice of informant and the choice of preference weights indicating that both factors should be considered when assessing CUA involving youth.

TidsskriftBMC Health Services Research
Antal sider11
StatusUdgivet - 24. jun. 2022

Bibliografisk note

Funding Information:
This study was supported by unrestricted grants from TrygFonden and the Lundbeck Foundation. The funding agencies were not involved in the study design, data collection, analysis and interpretation, the writing of the manuscript, or the decision on submission for publication.

Funding Information:
RTW, LBP, MMAP, AKP, WKS, KJP, SPN, DGH, MT, NB, PHT and PJ declare that they have no conflict of interest. CUC has been a consultant and/or advisor to or has received honoraria from: Acadia, Alkermes, Allergan, Angelini, Axsome, Gedeon Richter, Gerson Lehrman Group, IntraCellular Therapies, Janssen/J&J, LB Pharma, Lundbeck, MedAvante-ProPhase, Medscape, Neurocrine, Noven, Otsuka, Pfizer, Recordati, Rovi, Sumitomo Dainippon, Sunovion, Supernus, Takeda, and Teva. He has provided expert testimony for Janssen and Otsuka. He served on a Data Safety Monitoring Board for Lundbeck, Rovi, Supernus, and Teva. He received royalties from UpToDate and grant support from Janssen and Takeda. He is also a stock option holder of LB Pharma.

Funding Information:
The private, noncommercial health science research project Mind My Mind was initiated by Psykiatrifonden. Birthe Wielandt Houe acted as project manager on behalf of Psykiatrifonden. The randomized controlled effectiveness trial was conducted through close collaboration between Psykiatrifonden, the principal investigator (Pia Jeppesen), the participating municipalities, and the regional child and adolescent mental health centers. Psykiatrifonden held the legal responsibility as the data controller for the Web-based data collection.


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