TY - JOUR
T1 - Cost-effectiveness of 2-[18F]FDG-PET/CT versus CE-CT for response monitoring in patients with metastatic breast cancer
T2 - a register-based comparative study.
AU - Naghavi-Behzad, Mohammad
AU - Gerke, Oke
AU - Kodahl, Annette Raskov
AU - Vogsen, Marianne
AU - Asmussen, Jon Thor
AU - Weber, Wolfgang
AU - Hildebrandt, Malene Grubbe
AU - Kidholm, Kristian
PY - 2023/9/28
Y1 - 2023/9/28
N2 - We evaluated the cost-effectiveness of 2-[ 18F]FDG-PET/CT compared to CE-CT for response monitoring in metastatic breast cancer (MBC) patients. The study included 300 biopsy-verified MBC patients treated at Odense University Hospital (Denmark). CE-CT was used in 144 patients, 83 patients underwent 2-[ 18F]FDG-PET/CT, and 73 patients received a combination of both. Hospital resource-based costs (2007-2019) were adjusted to the 2019 level. The incremental cost-effectiveness ratio (ICER) was calculated by comparing average costs per patient and gained survival with CE-CT. During a median follow-up of 33.0 months, patients in the 2-[ 18F]FDG-PET/CT group had more short admissions (median 6 vs. 2) and fewer overnight admissions (5 vs. 12) compared to the CE-CT group. The mean total cost per patient was €91,547 for CE-CT, €83,965 for 2-[ 18F]FDG-PET/CT, and €165,784 for the combined group. The ICER for 2-[ 18F]FDG-PET/CT compared to CE-CT was €-527/month, indicating gaining an extra month of survival at a lower cost (€527). 2-[ 18F]FDG-PET/CT was more cost-effective in patients with favorable prognostic factors (oligometastatic or estrogen receptor-positive disease), while CE-CT was more cost-effective in poor prognosis patients (liver/lung metastases or performance status ≥ 2 at baseline). In conclusion, our study suggests that 2-[ 18F]FDG-PET/CT is a cost-effective modality for response monitoring in metastatic breast cancer.
AB - We evaluated the cost-effectiveness of 2-[ 18F]FDG-PET/CT compared to CE-CT for response monitoring in metastatic breast cancer (MBC) patients. The study included 300 biopsy-verified MBC patients treated at Odense University Hospital (Denmark). CE-CT was used in 144 patients, 83 patients underwent 2-[ 18F]FDG-PET/CT, and 73 patients received a combination of both. Hospital resource-based costs (2007-2019) were adjusted to the 2019 level. The incremental cost-effectiveness ratio (ICER) was calculated by comparing average costs per patient and gained survival with CE-CT. During a median follow-up of 33.0 months, patients in the 2-[ 18F]FDG-PET/CT group had more short admissions (median 6 vs. 2) and fewer overnight admissions (5 vs. 12) compared to the CE-CT group. The mean total cost per patient was €91,547 for CE-CT, €83,965 for 2-[ 18F]FDG-PET/CT, and €165,784 for the combined group. The ICER for 2-[ 18F]FDG-PET/CT compared to CE-CT was €-527/month, indicating gaining an extra month of survival at a lower cost (€527). 2-[ 18F]FDG-PET/CT was more cost-effective in patients with favorable prognostic factors (oligometastatic or estrogen receptor-positive disease), while CE-CT was more cost-effective in poor prognosis patients (liver/lung metastases or performance status ≥ 2 at baseline). In conclusion, our study suggests that 2-[ 18F]FDG-PET/CT is a cost-effective modality for response monitoring in metastatic breast cancer.
U2 - 10.1038/s41598-023-43446-7
DO - 10.1038/s41598-023-43446-7
M3 - Journal article
C2 - 37770525
SN - 2045-2322
VL - 13
JO - Scientific Reports
JF - Scientific Reports
M1 - 16315
ER -