CoryneRegNet - an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks

Jan Baumbach, Karina Brinkrolf, Lisa F Czaja, Sven Rahmann, Andreas Tauch

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silico models of bacterial cells that allow a systematic analysis of network behavior in response to changing environmental conditions.
OriginalsprogEngelsk
TidsskriftB M C Genomics
Vol/bind7
Sider (fra-til)24
ISSN1471-2164
DOI
StatusUdgivet - 2006
Udgivet eksterntJa

Fingeraftryk

Computer Simulation

Citer dette

Baumbach, Jan ; Brinkrolf, Karina ; Czaja, Lisa F ; Rahmann, Sven ; Tauch, Andreas. / CoryneRegNet - an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. I: B M C Genomics. 2006 ; Bind 7. s. 24.
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abstract = "The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silico models of bacterial cells that allow a systematic analysis of network behavior in response to changing environmental conditions.",
author = "Jan Baumbach and Karina Brinkrolf and Czaja, {Lisa F} and Sven Rahmann and Andreas Tauch",
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CoryneRegNet - an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. / Baumbach, Jan; Brinkrolf, Karina; Czaja, Lisa F; Rahmann, Sven; Tauch, Andreas.

I: B M C Genomics, Bind 7, 2006, s. 24.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - CoryneRegNet - an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks

AU - Baumbach, Jan

AU - Brinkrolf, Karina

AU - Czaja, Lisa F

AU - Rahmann, Sven

AU - Tauch, Andreas

PY - 2006

Y1 - 2006

N2 - The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silico models of bacterial cells that allow a systematic analysis of network behavior in response to changing environmental conditions.

AB - The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silico models of bacterial cells that allow a systematic analysis of network behavior in response to changing environmental conditions.

U2 - 10.1186/1471-2164-7-24

DO - 10.1186/1471-2164-7-24

M3 - Journal article

VL - 7

SP - 24

JO - B M C Genomics

JF - B M C Genomics

SN - 1471-2164

ER -