Cortical responses to sustained and divided attention in Alzheimer's disease.

Peter Johannsen, Johannes Klitgaard Jakobsen, Peter Bruhn, A Gjedde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 1999-Sep
OriginalsprogEngelsk
TidsskriftNeuroImage
Vol/bind10
Udgave nummer3 Pt 1
Sider (fra-til)269-81
Antal sider12
ISSN1053-8119
DOI
StatusUdgivet - 1999
Udgivet eksterntJa

Fingeraftryk

Alzheimer Disease
Gyrus Cinguli
Patient Rights

Bibliografisk note

Copyright 1999 Academic Press.

Citer dette

Johannsen, Peter ; Jakobsen, Johannes Klitgaard ; Bruhn, Peter ; Gjedde, A. / Cortical responses to sustained and divided attention in Alzheimer's disease. I: NeuroImage. 1999 ; Bind 10, Nr. 3 Pt 1. s. 269-81.
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title = "Cortical responses to sustained and divided attention in Alzheimer's disease.",
abstract = "Neuropsychological data suggests that divided attention is more impaired than sustained attention during the early phases of Alzheimer's disease. The purpose of the present study was to compare cerebral activation patterns during sustained and divided attention between Alzheimer patients and healthy elderly. The O-15-water PET activation method was used to map sustained and divided attention in 16 patients with Alzheimer's disease (mean age +/- SD: 68 +/- 5 years; MMSE: 11-25, mean +/- SD = 19.5 +/- 4.9) and in 16 healthy age-matched control subjects. After stereotactical normalization, voxel-by-voxel t statistics was used to assess the significance of activated brain areas and to compare activations between patients and control subjects. In the healthy elderly, sustained and divided attention both elicited activation of the right inferior parietal lobule, and the right middle frontal gyrus, whereas the anterior cingulate gyrus was activated during sustained attention only. Only medial frontal structures (Brodmann Area (BA) 32/34) were activated in Alzheimer patients, and both frontal (BA-10), posterior cingulate (BA-23/31), and subcortical sites were deactivated. Compared to the healthy elderly, the activations in the patients of the right medial (BA-11) superior (BA-10) and inferior (BA-47) frontal gyri, the right middle temporal (BA-20), and the left lingual (BA-17) gyri were significantly reduced. More cortical sites differed statistically between Alzheimer patients and control subjects during divided than during sustained attention. The activation pattern elicited by attention supports the neuropsychological data that divided attention is more impaired than sustained attention in early Alzheimer's disease.",
author = "Peter Johannsen and Jakobsen, {Johannes Klitgaard} and Peter Bruhn and A Gjedde",
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Cortical responses to sustained and divided attention in Alzheimer's disease. / Johannsen, Peter; Jakobsen, Johannes Klitgaard; Bruhn, Peter; Gjedde, A.

I: NeuroImage, Bind 10, Nr. 3 Pt 1, 1999, s. 269-81.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cortical responses to sustained and divided attention in Alzheimer's disease.

AU - Johannsen, Peter

AU - Jakobsen, Johannes Klitgaard

AU - Bruhn, Peter

AU - Gjedde, A

N1 - Copyright 1999 Academic Press.

PY - 1999

Y1 - 1999

N2 - Neuropsychological data suggests that divided attention is more impaired than sustained attention during the early phases of Alzheimer's disease. The purpose of the present study was to compare cerebral activation patterns during sustained and divided attention between Alzheimer patients and healthy elderly. The O-15-water PET activation method was used to map sustained and divided attention in 16 patients with Alzheimer's disease (mean age +/- SD: 68 +/- 5 years; MMSE: 11-25, mean +/- SD = 19.5 +/- 4.9) and in 16 healthy age-matched control subjects. After stereotactical normalization, voxel-by-voxel t statistics was used to assess the significance of activated brain areas and to compare activations between patients and control subjects. In the healthy elderly, sustained and divided attention both elicited activation of the right inferior parietal lobule, and the right middle frontal gyrus, whereas the anterior cingulate gyrus was activated during sustained attention only. Only medial frontal structures (Brodmann Area (BA) 32/34) were activated in Alzheimer patients, and both frontal (BA-10), posterior cingulate (BA-23/31), and subcortical sites were deactivated. Compared to the healthy elderly, the activations in the patients of the right medial (BA-11) superior (BA-10) and inferior (BA-47) frontal gyri, the right middle temporal (BA-20), and the left lingual (BA-17) gyri were significantly reduced. More cortical sites differed statistically between Alzheimer patients and control subjects during divided than during sustained attention. The activation pattern elicited by attention supports the neuropsychological data that divided attention is more impaired than sustained attention in early Alzheimer's disease.

AB - Neuropsychological data suggests that divided attention is more impaired than sustained attention during the early phases of Alzheimer's disease. The purpose of the present study was to compare cerebral activation patterns during sustained and divided attention between Alzheimer patients and healthy elderly. The O-15-water PET activation method was used to map sustained and divided attention in 16 patients with Alzheimer's disease (mean age +/- SD: 68 +/- 5 years; MMSE: 11-25, mean +/- SD = 19.5 +/- 4.9) and in 16 healthy age-matched control subjects. After stereotactical normalization, voxel-by-voxel t statistics was used to assess the significance of activated brain areas and to compare activations between patients and control subjects. In the healthy elderly, sustained and divided attention both elicited activation of the right inferior parietal lobule, and the right middle frontal gyrus, whereas the anterior cingulate gyrus was activated during sustained attention only. Only medial frontal structures (Brodmann Area (BA) 32/34) were activated in Alzheimer patients, and both frontal (BA-10), posterior cingulate (BA-23/31), and subcortical sites were deactivated. Compared to the healthy elderly, the activations in the patients of the right medial (BA-11) superior (BA-10) and inferior (BA-47) frontal gyri, the right middle temporal (BA-20), and the left lingual (BA-17) gyri were significantly reduced. More cortical sites differed statistically between Alzheimer patients and control subjects during divided than during sustained attention. The activation pattern elicited by attention supports the neuropsychological data that divided attention is more impaired than sustained attention in early Alzheimer's disease.

U2 - 10.1006/nimg.1999.0475

DO - 10.1006/nimg.1999.0475

M3 - Journal article

C2 - 10458942

VL - 10

SP - 269

EP - 281

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 3 Pt 1

ER -