Cord blood IgE. III. Prediction of IgE high-response and allergy. A follow-up at the age of 18 months

L G Hansen, A Høst, S Halken, A Holmskov, S Husby, L B Lassen, K Storm, O Osterballe

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1-year birth cohorts (1983-1984 and 1985-1986) in Denmark (n = 1189 + 1625). For follow-up we chose all infants with cord blood IgE greater than or equal to 0.5 kU/l and a randomly chosen group of the same size with cord blood IgE less than 0.5 kU/l. A total group of 762 infants were clinically evaluated at 18 months of age, and in 688 of these we evaluated total and specific IgE. A diagnosis of definite atopy, probable atopy or no atopy was established. In the present study we defined allergic disease as atopic disease combined with elevated total IgE. We found a statistically significant correlation between cord blood IgE and IgE at 18 months of age. Significantly more infants with elevated cord blood IgE had developed allergic disease at 18 months. A cut-off value of 0.3 kU/l for cord blood IgE was superior to the originally suggested 0.5 kU/l. Significantly more infants with elevated cord blood IgE had developed specific IgE antibodies at 18 months. The most frequent specific IgE antibody was towards cow's milk. Specific IgE antibodies were very rarely found when total IgE was not elevated. A total IgE at the age of 18 months greater than 26 kU/l could be regarded as elevated. With regard to allergic disease the positive predictive values of cord blood IgE greater than or equal to 0.3 kU/l in the 2 series were 21% and the corresponding sensitivities 67% and 46%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

OriginalsprogEngelsk
TidsskriftAllergy
Vol/bind47
Udgave nummer4 Pt 2
Sider (fra-til)404-10
Antal sider7
ISSN0105-4538
StatusUdgivet - aug. 1992

Fingeraftryk

Fetal Blood
Hypersensitivity
Denmark

Citer dette

Hansen, L. G., Høst, A., Halken, S., Holmskov, A., Husby, S., Lassen, L. B., ... Osterballe, O. (1992). Cord blood IgE. III. Prediction of IgE high-response and allergy. A follow-up at the age of 18 months. Allergy, 47(4 Pt 2), 404-10.
Hansen, L G ; Høst, A ; Halken, S ; Holmskov, A ; Husby, S ; Lassen, L B ; Storm, K ; Osterballe, O. / Cord blood IgE. III. Prediction of IgE high-response and allergy. A follow-up at the age of 18 months. I: Allergy. 1992 ; Bind 47, Nr. 4 Pt 2. s. 404-10.
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abstract = "Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1-year birth cohorts (1983-1984 and 1985-1986) in Denmark (n = 1189 + 1625). For follow-up we chose all infants with cord blood IgE greater than or equal to 0.5 kU/l and a randomly chosen group of the same size with cord blood IgE less than 0.5 kU/l. A total group of 762 infants were clinically evaluated at 18 months of age, and in 688 of these we evaluated total and specific IgE. A diagnosis of definite atopy, probable atopy or no atopy was established. In the present study we defined allergic disease as atopic disease combined with elevated total IgE. We found a statistically significant correlation between cord blood IgE and IgE at 18 months of age. Significantly more infants with elevated cord blood IgE had developed allergic disease at 18 months. A cut-off value of 0.3 kU/l for cord blood IgE was superior to the originally suggested 0.5 kU/l. Significantly more infants with elevated cord blood IgE had developed specific IgE antibodies at 18 months. The most frequent specific IgE antibody was towards cow's milk. Specific IgE antibodies were very rarely found when total IgE was not elevated. A total IgE at the age of 18 months greater than 26 kU/l could be regarded as elevated. With regard to allergic disease the positive predictive values of cord blood IgE greater than or equal to 0.3 kU/l in the 2 series were 21{\%} and the corresponding sensitivities 67{\%} and 46{\%}, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)",
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Hansen, LG, Høst, A, Halken, S, Holmskov, A, Husby, S, Lassen, LB, Storm, K & Osterballe, O 1992, 'Cord blood IgE. III. Prediction of IgE high-response and allergy. A follow-up at the age of 18 months', Allergy, bind 47, nr. 4 Pt 2, s. 404-10.

Cord blood IgE. III. Prediction of IgE high-response and allergy. A follow-up at the age of 18 months. / Hansen, L G; Høst, A; Halken, S; Holmskov, A; Husby, S; Lassen, L B; Storm, K; Osterballe, O.

I: Allergy, Bind 47, Nr. 4 Pt 2, 08.1992, s. 404-10.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cord blood IgE. III. Prediction of IgE high-response and allergy. A follow-up at the age of 18 months

AU - Hansen, L G

AU - Høst, A

AU - Halken, S

AU - Holmskov, A

AU - Husby, S

AU - Lassen, L B

AU - Storm, K

AU - Osterballe, O

PY - 1992/8

Y1 - 1992/8

N2 - Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1-year birth cohorts (1983-1984 and 1985-1986) in Denmark (n = 1189 + 1625). For follow-up we chose all infants with cord blood IgE greater than or equal to 0.5 kU/l and a randomly chosen group of the same size with cord blood IgE less than 0.5 kU/l. A total group of 762 infants were clinically evaluated at 18 months of age, and in 688 of these we evaluated total and specific IgE. A diagnosis of definite atopy, probable atopy or no atopy was established. In the present study we defined allergic disease as atopic disease combined with elevated total IgE. We found a statistically significant correlation between cord blood IgE and IgE at 18 months of age. Significantly more infants with elevated cord blood IgE had developed allergic disease at 18 months. A cut-off value of 0.3 kU/l for cord blood IgE was superior to the originally suggested 0.5 kU/l. Significantly more infants with elevated cord blood IgE had developed specific IgE antibodies at 18 months. The most frequent specific IgE antibody was towards cow's milk. Specific IgE antibodies were very rarely found when total IgE was not elevated. A total IgE at the age of 18 months greater than 26 kU/l could be regarded as elevated. With regard to allergic disease the positive predictive values of cord blood IgE greater than or equal to 0.3 kU/l in the 2 series were 21% and the corresponding sensitivities 67% and 46%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1-year birth cohorts (1983-1984 and 1985-1986) in Denmark (n = 1189 + 1625). For follow-up we chose all infants with cord blood IgE greater than or equal to 0.5 kU/l and a randomly chosen group of the same size with cord blood IgE less than 0.5 kU/l. A total group of 762 infants were clinically evaluated at 18 months of age, and in 688 of these we evaluated total and specific IgE. A diagnosis of definite atopy, probable atopy or no atopy was established. In the present study we defined allergic disease as atopic disease combined with elevated total IgE. We found a statistically significant correlation between cord blood IgE and IgE at 18 months of age. Significantly more infants with elevated cord blood IgE had developed allergic disease at 18 months. A cut-off value of 0.3 kU/l for cord blood IgE was superior to the originally suggested 0.5 kU/l. Significantly more infants with elevated cord blood IgE had developed specific IgE antibodies at 18 months. The most frequent specific IgE antibody was towards cow's milk. Specific IgE antibodies were very rarely found when total IgE was not elevated. A total IgE at the age of 18 months greater than 26 kU/l could be regarded as elevated. With regard to allergic disease the positive predictive values of cord blood IgE greater than or equal to 0.3 kU/l in the 2 series were 21% and the corresponding sensitivities 67% and 46%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

KW - Animals

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Fetal Blood

KW - Follow-Up Studies

KW - Humans

KW - Hypersensitivity, Immediate

KW - Immunoglobulin E

KW - Infant

KW - Male

KW - Milk

KW - Predictive Value of Tests

KW - Sensitivity and Specificity

M3 - Journal article

VL - 47

SP - 404

EP - 410

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 4 Pt 2

ER -