Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm

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Abstrakt

Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with plectasin derivate NZ2114 in an attempt to design an S. aureus biofilm-resistant catheter. The material demonstrated promising antibiofilm properties, including properties against methicillin-resistant S. aureus, thus suggesting a novel application of this antimicrobial peptide.
OriginalsprogEngelsk
Artikelnummere00604-17
TidsskriftAntimicrobial Agents and Chemotherapy
Vol/bind61
Udgave nummer7
Antal sider6
ISSN0066-4804
DOI
StatusUdgivet - 2017

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