Controlled generation and use of CO in flow

Steffen V. F. Hansen, Zoe E. Wilson, Trond Ulven, Steven V. Ley

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Resumé

A method for the generation and use of carbon monoxide in flow chemistry has been developed. By using a tube-in-tube reactor, oxalyl chloride can be conveniently and safely hydrolyzed using a NaOH solution to generate CO in the outer stream, which then passes through AF-2400 semi-permeable inner tubing to enrich a reaction stream where it is consumed. The tube-in-tube reactor allows the generation of CO under conditions which would otherwise be incompatible with the reaction conditions. In this way carbonylations can be successfully performed in flow without the use of pressurized gas cylinders. Both alkoxy- and aminocarbonylation was carried out in flow, including a 320 minute continuous run, as proof of concept.
OriginalsprogEngelsk
TidsskriftReaction Chemistry & Engineering
Vol/bind1
Udgave nummer3
Sider (fra-til)280-287
ISSN2058-9883
DOI
StatusUdgivet - 2016

Fingeraftryk

Carbon Monoxide
Gas cylinders
Carbonylation
Tubing

Citer dette

Hansen, S. V. F., Wilson, Z. E., Ulven, T., & Ley, S. V. (2016). Controlled generation and use of CO in flow. Reaction Chemistry & Engineering, 1(3), 280-287. https://doi.org/10.1039/C6RE00020G
Hansen, Steffen V. F. ; Wilson, Zoe E. ; Ulven, Trond ; Ley, Steven V. / Controlled generation and use of CO in flow. I: Reaction Chemistry & Engineering. 2016 ; Bind 1, Nr. 3. s. 280-287.
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Hansen, SVF, Wilson, ZE, Ulven, T & Ley, SV 2016, 'Controlled generation and use of CO in flow', Reaction Chemistry & Engineering, bind 1, nr. 3, s. 280-287. https://doi.org/10.1039/C6RE00020G

Controlled generation and use of CO in flow. / Hansen, Steffen V. F.; Wilson, Zoe E.; Ulven, Trond; Ley, Steven V.

I: Reaction Chemistry & Engineering, Bind 1, Nr. 3, 2016, s. 280-287.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Controlled generation and use of CO in flow

AU - Hansen, Steffen V. F.

AU - Wilson, Zoe E.

AU - Ulven, Trond

AU - Ley, Steven V.

PY - 2016

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AB - A method for the generation and use of carbon monoxide in flow chemistry has been developed. By using a tube-in-tube reactor, oxalyl chloride can be conveniently and safely hydrolyzed using a NaOH solution to generate CO in the outer stream, which then passes through AF-2400 semi-permeable inner tubing to enrich a reaction stream where it is consumed. The tube-in-tube reactor allows the generation of CO under conditions which would otherwise be incompatible with the reaction conditions. In this way carbonylations can be successfully performed in flow without the use of pressurized gas cylinders. Both alkoxy- and aminocarbonylation was carried out in flow, including a 320 minute continuous run, as proof of concept.

U2 - 10.1039/C6RE00020G

DO - 10.1039/C6RE00020G

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