Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

V. E. Gruzdev; D. Korkin; B. P. Mooney; J. F. Havelund; I. M. Møller; J. J. Thelen

doi:10.1109/LO.2018.8435786

Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

V. E. Gruzdev
, D. Korkin
, B. P. Mooney
, J. F. Havelund
, I. M. Møller
, J. J. Thelen

Institut for Biokemi og Molekylær Biologi

University of Missouri
Worcester Polytechnic Institute
Aarhus Universitet

Publikation: Kapitel i bog/rapport/konference-proceeding › Konferencebidrag i proceedings › Forskning › peer review

Abstract

Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

Originalsprog	Engelsk
Titel	Proceedings - International Conference Laser Optics 2018 : ICLO 2018
Antal sider	1
Forlag	IEEE
Publikationsdato	aug. 2018
Artikelnummer	8435786
ISBN (Trykt)	9781538636121
DOI	https://doi.org/10.1109/LO.2018.8435786
Status	Udgivet - aug. 2018
Begivenhed	2018 International Conference Laser Optics, ICLO 2018 - St. Petersburg, Rusland Varighed: 4. jun. 2018 → 8. jun. 2018

Konference

Konference	2018 International Conference Laser Optics, ICLO 2018
Land/Område	Rusland
By	St. Petersburg
Periode	04/06/2018 → 08/06/2018

Dokumenter og links

10.1109/LO.2018.8435786

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

@inproceedings{40bd391b0e4c4a98b33b05d83cce45ae,

title = "Controlled chemical modification of biomolecules by femtosecond laser in polar liquids",

abstract = "Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.",

keywords = "Biochemistry, Molecular biophysics, Peptide, Photochemistry, Protein engineering, Proteins",

author = "Gruzdev, \{V. E.\} and D. Korkin and Mooney, \{B. P.\} and Havelund, \{J. F.\} and M{\o}ller, \{I. M.\} and Thelen, \{J. J.\}",

year = "2018",

month = aug,

doi = "10.1109/LO.2018.8435786",

language = "English",

isbn = "9781538636121",

booktitle = "Proceedings - International Conference Laser Optics 2018",

publisher = "IEEE",

address = "United States",

note = "2018 International Conference Laser Optics, ICLO 2018 ; Conference date: 04-06-2018 Through 08-06-2018",

}

Gruzdev, VE, Korkin, D, Mooney, BP, Havelund, JF, Møller, IM & Thelen, JJ 2018, Controlled chemical modification of biomolecules by femtosecond laser in polar liquids. i Proceedings - International Conference Laser Optics 2018: ICLO 2018., 8435786, IEEE, 2018 International Conference Laser Optics, ICLO 2018, St. Petersburg, Rusland, 04/06/2018. https://doi.org/10.1109/LO.2018.8435786

TY - GEN

T1 - Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

AU - Gruzdev, V. E.

AU - Korkin, D.

AU - Mooney, B. P.

AU - Havelund, J. F.

AU - Møller, I. M.

AU - Thelen, J. J.

PY - 2018/8

Y1 - 2018/8

N2 - Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

AB - Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

KW - Biochemistry

KW - Molecular biophysics

KW - Peptide

KW - Photochemistry

KW - Protein engineering

KW - Proteins

U2 - 10.1109/LO.2018.8435786

DO - 10.1109/LO.2018.8435786

M3 - Article in proceedings

AN - SCOPUS:85052507930

SN - 9781538636121

BT - Proceedings - International Conference Laser Optics 2018

PB - IEEE

T2 - 2018 International Conference Laser Optics, ICLO 2018

Y2 - 4 June 2018 through 8 June 2018

ER -

Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

Abstract

Konference

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater