Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

V. E. Gruzdev; D. Korkin; B. P. Mooney; J. F. Havelund; I. M. Møller; J. J. Thelen

doi:10.1109/LO.2018.8435786

Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

V. E. Gruzdev, D. Korkin, B. P. Mooney, J. F. Havelund, I. M. Møller, J. J. Thelen

Institut for Biokemi og Molekylær Biologi

Publikation: Kapitel i bog/rapport/konference-proceeding › Konferencebidrag i proceedings › Forskning › peer review

Abstract

Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

Originalsprog	Engelsk
Titel	Proceedings - International Conference Laser Optics 2018 : ICLO 2018
Antal sider	1
Forlag	IEEE
Publikationsdato	aug. 2018
Artikelnummer	8435786
ISBN (Trykt)	9781538636121
DOI	https://doi.org/10.1109/LO.2018.8435786
Status	Udgivet - aug. 2018
Begivenhed	2018 International Conference Laser Optics, ICLO 2018 - St. Petersburg, Rusland Varighed: 4. jun. 2018 → 8. jun. 2018

Konference

Konference	2018 International Conference Laser Optics, ICLO 2018
Land/Område	Rusland
By	St. Petersburg
Periode	04/06/2018 → 08/06/2018

Dokumenter og links

10.1109/LO.2018.8435786

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

@inproceedings{40bd391b0e4c4a98b33b05d83cce45ae,

title = "Controlled chemical modification of biomolecules by femtosecond laser in polar liquids",

abstract = "Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.",

keywords = "Biochemistry, Molecular biophysics, Peptide, Photochemistry, Protein engineering, Proteins",

author = "Gruzdev, {V. E.} and D. Korkin and Mooney, {B. P.} and Havelund, {J. F.} and M{\o}ller, {I. M.} and Thelen, {J. J.}",

year = "2018",

month = aug,

doi = "10.1109/LO.2018.8435786",

language = "English",

isbn = "9781538636121",

booktitle = "Proceedings - International Conference Laser Optics 2018",

publisher = "IEEE",

address = "United States",

note = "2018 International Conference Laser Optics, ICLO 2018 ; Conference date: 04-06-2018 Through 08-06-2018",

}

Gruzdev, VE, Korkin, D, Mooney, BP, Havelund, JF, Møller, IM & Thelen, JJ 2018, Controlled chemical modification of biomolecules by femtosecond laser in polar liquids. i Proceedings - International Conference Laser Optics 2018: ICLO 2018., 8435786, IEEE, 2018 International Conference Laser Optics, ICLO 2018, St. Petersburg, Rusland, 04/06/2018. https://doi.org/10.1109/LO.2018.8435786

TY - GEN

T1 - Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

AU - Gruzdev, V. E.

AU - Korkin, D.

AU - Mooney, B. P.

AU - Havelund, J. F.

AU - Møller, I. M.

AU - Thelen, J. J.

PY - 2018/8

Y1 - 2018/8

N2 - Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

AB - Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

KW - Biochemistry

KW - Molecular biophysics

KW - Peptide

KW - Photochemistry

KW - Protein engineering

KW - Proteins

U2 - 10.1109/LO.2018.8435786

DO - 10.1109/LO.2018.8435786

M3 - Article in proceedings

AN - SCOPUS:85052507930

SN - 9781538636121

BT - Proceedings - International Conference Laser Optics 2018

PB - IEEE

T2 - 2018 International Conference Laser Optics, ICLO 2018

Y2 - 4 June 2018 through 8 June 2018

ER -

Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

Abstract

Konference

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater