Purpose: To investigate the efficacy of myopia control defined by axial elongation and safety of orthokeratology lenses (OKL) in a Scandinavian (Danish) population. Methods: Sixty Danish children aged 6–12 years with myopia ranging from 0.5 to 4.75 dioptres (D) spherical component and refractive astigmatism ≤2.5 D in both eyes were randomly assigned to either OKL or single-vision spectacles (SVS). Study duration was 18 months. Outcome measures were axial length (AL) measured with Lenstar LS900 (Haag-Streit, Koeniz, Switzerland) and adverse events graded with Efron Grading Scale for Contact Lens Complications. Results: Nineteen participants completed the 18-month follow-up in the OKL group and 28 in the SVS group. The average AL elongation in the OKL group was 0.24 mm smaller as compared to the SVS group (95% confidence interval 0.12–0.36, mixed model adjusted for baseline sex, age and AL). There were no fast progressors (>0.75 D/year) in the OKL group during the follow-up period in contrast to 22% in the SVS group. No treatment-requiring or vision-threatening adverse events were observed. Conclusion: Orthokeratology lenses reduced AL elongation in myopic Scandinavian children by 59%, with no treatment-requiring or vision-threatening adverse events. The results align with outcomes of previous clinical trials.
Bibliografisk noteFunding Information:
The study was supported by grants from the Region of Southern Denmark; Forskningsrådet at University Hospital of Southern Denmark, Vejle Hospital; Bagenkop Nielsen Myopia Foundation; Fabrikant Einar Willumsen Foundation; Læge Frk. K Rasmussen Foundation; Gangsted Foundation, Fight for Sight, Denmark; Overlæge Jørgen Werner Schous og hustru Else‐Marie Schou, født Wonge Foundation; Henry og Astrid Møller Foundation; Grosserer Chr Andersen og hustru Foundation; The Danish Eye Research Foundation; Helsefonden.
© 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation