Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

Trine P Petersen, Anders Foller Larsen, Andreas Ritzén, Trond Ulven

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.
OriginalsprogEngelsk
TidsskriftJournal of Organic Chemistry
Vol/bind78
Udgave nummer8
Sider (fra-til)4190-5
Antal sider6
ISSN0022-3263
DOI
StatusUdgivet - 2013

Fingeraftryk

Substitution reactions
Decomposition
dimethylamine

Citer dette

Petersen, Trine P ; Larsen, Anders Foller ; Ritzén, Andreas ; Ulven, Trond. / Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF. I: Journal of Organic Chemistry. 2013 ; Bind 78, Nr. 8. s. 4190-5.
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abstract = "A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.",
author = "Petersen, {Trine P} and Larsen, {Anders Foller} and Andreas Ritz{\'e}n and Trond Ulven",
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Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF. / Petersen, Trine P; Larsen, Anders Foller; Ritzén, Andreas; Ulven, Trond.

I: Journal of Organic Chemistry, Bind 78, Nr. 8, 2013, s. 4190-5.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

AU - Petersen, Trine P

AU - Larsen, Anders Foller

AU - Ritzén, Andreas

AU - Ulven, Trond

PY - 2013

Y1 - 2013

N2 - A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

AB - A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

U2 - 10.1021/jo400390t

DO - 10.1021/jo400390t

M3 - Journal article

VL - 78

SP - 4190

EP - 4195

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

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