Content of n-3 LC-PUFA in Breast Milk Four Months Postpartum is Associated with Infancy Blood Pressure in Boys and Infancy Blood Lipid Profile in Girls

Signe Bruun*, Lenie van Rossem, Lotte Lauritzen, Steffen Husby, Lotte Neergaard Jacobsen, Kim F. Michaelsen, Maria Boysen Sandberg, Ken D. Stark, Jan Sørensen, Gitte Zachariassen

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Resumé

Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = -20.0 (95% CI = -33.4, -6.7), p = 0.004 and β = -10.2 (95% CI = -19.8, -0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = -0.7 (95% CI = -1.1, -0.3), p = 0.001 and β = 3.1 (95% CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.

OriginalsprogEngelsk
Artikelnummer235
TidsskriftNutrients
Vol/bind11
Udgave nummer2
Antal sider16
ISSN2072-6643
DOI
StatusUdgivet - 22. jan. 2019

Fingeraftryk

long chain polyunsaturated fatty acids
infancy
Human Milk
breast milk
Unsaturated Fatty Acids
blood lipids
blood pressure
Lipids
childhood
gender
diastolic blood pressure
gestational age
breast feeding
systolic blood pressure
educational status
Mothers
adulthood
high density lipoprotein cholesterol
body mass index
early development

Citer dette

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title = "Content of n-3 LC-PUFA in Breast Milk Four Months Postpartum is Associated with Infancy Blood Pressure in Boys and Infancy Blood Lipid Profile in Girls",
abstract = "Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = -20.0 (95{\%} CI = -33.4, -6.7), p = 0.004 and β = -10.2 (95{\%} CI = -19.8, -0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = -0.7 (95{\%} CI = -1.1, -0.3), p = 0.001 and β = 3.1 (95{\%} CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.",
keywords = "cardiovascular health, cholesterol, cohort study, fatty acids, human milk, milk composition, omega-3, triglyceride",
author = "Signe Bruun and {van Rossem}, Lenie and Lotte Lauritzen and Steffen Husby and {Neergaard Jacobsen}, Lotte and Michaelsen, {Kim F.} and {Boysen Sandberg}, Maria and Stark, {Ken D.} and Jan S{\o}rensen and Gitte Zachariassen",
year = "2019",
month = "1",
day = "22",
doi = "10.3390/nu11020235",
language = "English",
volume = "11",
journal = "Nutrients",
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Content of n-3 LC-PUFA in Breast Milk Four Months Postpartum is Associated with Infancy Blood Pressure in Boys and Infancy Blood Lipid Profile in Girls. / Bruun, Signe; van Rossem, Lenie; Lauritzen, Lotte; Husby, Steffen; Neergaard Jacobsen, Lotte; Michaelsen, Kim F.; Boysen Sandberg, Maria; Stark, Ken D.; Sørensen, Jan; Zachariassen, Gitte.

I: Nutrients, Bind 11, Nr. 2, 235, 22.01.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Content of n-3 LC-PUFA in Breast Milk Four Months Postpartum is Associated with Infancy Blood Pressure in Boys and Infancy Blood Lipid Profile in Girls

AU - Bruun, Signe

AU - van Rossem, Lenie

AU - Lauritzen, Lotte

AU - Husby, Steffen

AU - Neergaard Jacobsen, Lotte

AU - Michaelsen, Kim F.

AU - Boysen Sandberg, Maria

AU - Stark, Ken D.

AU - Sørensen, Jan

AU - Zachariassen, Gitte

PY - 2019/1/22

Y1 - 2019/1/22

N2 - Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = -20.0 (95% CI = -33.4, -6.7), p = 0.004 and β = -10.2 (95% CI = -19.8, -0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = -0.7 (95% CI = -1.1, -0.3), p = 0.001 and β = 3.1 (95% CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.

AB - Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = -20.0 (95% CI = -33.4, -6.7), p = 0.004 and β = -10.2 (95% CI = -19.8, -0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = -0.7 (95% CI = -1.1, -0.3), p = 0.001 and β = 3.1 (95% CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.

KW - cardiovascular health

KW - cholesterol

KW - cohort study

KW - fatty acids

KW - human milk

KW - milk composition

KW - omega-3

KW - triglyceride

U2 - 10.3390/nu11020235

DO - 10.3390/nu11020235

M3 - Journal article

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 2

M1 - 235

ER -