Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications

Jacob Eifer Møller, Bente Brendorp, Michael Ottesen, Lars Køber, Kenneth Egstrup, Steen Hvitfelt Poulsen, Christian Torp-Pedersen, Bucindolol Evaluation in Acute Myocardial Infarction Trail Group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

AIMS: To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction.

METHODS: 3166 consecutive patients screened for entry in the Bucindolol Evaluation in Acute Myocardial Infarction Trial with definite acute myocardial infarction and echocardiographic assessment of left ventricular systolic function were included between 1998 and 1999 in this prospective observational study. Main outcome measures were occurrences of in-hospital complications and all cause mortality.

RESULTS: Congestive heart failure was seen during hospitalisation in 1464 patients (46%), 717 patients had preserved left ventricular systolic function (wall motion index > or =1.3 corresponding to ejection fraction > or =0.40), and 732 patients had systolic dysfunction (wall motion index <1.3). One year mortality in patients with no heart failure, heart failure with preserved systolic function, and heart failure with systolic dysfunction were 6, 22 and 35%, P<0.0001. Unadjusted risk of death from all causes associated with heart failure and preserved systolic function was 3.3 (95% CI 2.8-4.0), and after adjustment for baseline characteristics and left ventricular systolic function in multivariate Cox proportional hazards analysis the risk was 2.1 (95% CI 1.7-2.6), P<0.0001.

CONCLUSIONS: Congestive heart failure is frequently present in patients with preserved left ventricular systolic function, and is associated with increased risk of in-hospital complications and death following acute myocardial infarction.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Heart Failure
Vol/bind5
Udgave nummer6
Sider (fra-til)811-9
Antal sider9
ISSN1388-9842
StatusUdgivet - dec. 2003

Fingeraftryk

Left Ventricular Function
Systolic Heart Failure
Cause of Death
Outcome Assessment (Health Care)
Prospective Studies

Citer dette

Møller, J. E., Brendorp, B., Ottesen, M., Køber, L., Egstrup, K., Poulsen, S. H., ... Bucindolol Evaluation in Acute Myocardial Infarction Trail Group (2003). Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications. European Journal of Heart Failure, 5(6), 811-9.
Møller, Jacob Eifer ; Brendorp, Bente ; Ottesen, Michael ; Køber, Lars ; Egstrup, Kenneth ; Poulsen, Steen Hvitfelt ; Torp-Pedersen, Christian ; Bucindolol Evaluation in Acute Myocardial Infarction Trail Group. / Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction : clinical and prognostic implications. I: European Journal of Heart Failure. 2003 ; Bind 5, Nr. 6. s. 811-9.
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title = "Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications",
abstract = "AIMS: To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction.METHODS: 3166 consecutive patients screened for entry in the Bucindolol Evaluation in Acute Myocardial Infarction Trial with definite acute myocardial infarction and echocardiographic assessment of left ventricular systolic function were included between 1998 and 1999 in this prospective observational study. Main outcome measures were occurrences of in-hospital complications and all cause mortality.RESULTS: Congestive heart failure was seen during hospitalisation in 1464 patients (46{\%}), 717 patients had preserved left ventricular systolic function (wall motion index > or =1.3 corresponding to ejection fraction > or =0.40), and 732 patients had systolic dysfunction (wall motion index <1.3). One year mortality in patients with no heart failure, heart failure with preserved systolic function, and heart failure with systolic dysfunction were 6, 22 and 35{\%}, P<0.0001. Unadjusted risk of death from all causes associated with heart failure and preserved systolic function was 3.3 (95{\%} CI 2.8-4.0), and after adjustment for baseline characteristics and left ventricular systolic function in multivariate Cox proportional hazards analysis the risk was 2.1 (95{\%} CI 1.7-2.6), P<0.0001.CONCLUSIONS: Congestive heart failure is frequently present in patients with preserved left ventricular systolic function, and is associated with increased risk of in-hospital complications and death following acute myocardial infarction.",
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author = "M{\o}ller, {Jacob Eifer} and Bente Brendorp and Michael Ottesen and Lars K{\o}ber and Kenneth Egstrup and Poulsen, {Steen Hvitfelt} and Christian Torp-Pedersen and {Bucindolol Evaluation in Acute Myocardial Infarction Trail Group}",
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Møller, JE, Brendorp, B, Ottesen, M, Køber, L, Egstrup, K, Poulsen, SH, Torp-Pedersen, C & Bucindolol Evaluation in Acute Myocardial Infarction Trail Group 2003, 'Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications', European Journal of Heart Failure, bind 5, nr. 6, s. 811-9.

Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction : clinical and prognostic implications. / Møller, Jacob Eifer; Brendorp, Bente; Ottesen, Michael; Køber, Lars; Egstrup, Kenneth; Poulsen, Steen Hvitfelt; Torp-Pedersen, Christian; Bucindolol Evaluation in Acute Myocardial Infarction Trail Group.

I: European Journal of Heart Failure, Bind 5, Nr. 6, 12.2003, s. 811-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction

T2 - clinical and prognostic implications

AU - Møller, Jacob Eifer

AU - Brendorp, Bente

AU - Ottesen, Michael

AU - Køber, Lars

AU - Egstrup, Kenneth

AU - Poulsen, Steen Hvitfelt

AU - Torp-Pedersen, Christian

AU - Bucindolol Evaluation in Acute Myocardial Infarction Trail Group

PY - 2003/12

Y1 - 2003/12

N2 - AIMS: To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction.METHODS: 3166 consecutive patients screened for entry in the Bucindolol Evaluation in Acute Myocardial Infarction Trial with definite acute myocardial infarction and echocardiographic assessment of left ventricular systolic function were included between 1998 and 1999 in this prospective observational study. Main outcome measures were occurrences of in-hospital complications and all cause mortality.RESULTS: Congestive heart failure was seen during hospitalisation in 1464 patients (46%), 717 patients had preserved left ventricular systolic function (wall motion index > or =1.3 corresponding to ejection fraction > or =0.40), and 732 patients had systolic dysfunction (wall motion index <1.3). One year mortality in patients with no heart failure, heart failure with preserved systolic function, and heart failure with systolic dysfunction were 6, 22 and 35%, P<0.0001. Unadjusted risk of death from all causes associated with heart failure and preserved systolic function was 3.3 (95% CI 2.8-4.0), and after adjustment for baseline characteristics and left ventricular systolic function in multivariate Cox proportional hazards analysis the risk was 2.1 (95% CI 1.7-2.6), P<0.0001.CONCLUSIONS: Congestive heart failure is frequently present in patients with preserved left ventricular systolic function, and is associated with increased risk of in-hospital complications and death following acute myocardial infarction.

AB - AIMS: To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction.METHODS: 3166 consecutive patients screened for entry in the Bucindolol Evaluation in Acute Myocardial Infarction Trial with definite acute myocardial infarction and echocardiographic assessment of left ventricular systolic function were included between 1998 and 1999 in this prospective observational study. Main outcome measures were occurrences of in-hospital complications and all cause mortality.RESULTS: Congestive heart failure was seen during hospitalisation in 1464 patients (46%), 717 patients had preserved left ventricular systolic function (wall motion index > or =1.3 corresponding to ejection fraction > or =0.40), and 732 patients had systolic dysfunction (wall motion index <1.3). One year mortality in patients with no heart failure, heart failure with preserved systolic function, and heart failure with systolic dysfunction were 6, 22 and 35%, P<0.0001. Unadjusted risk of death from all causes associated with heart failure and preserved systolic function was 3.3 (95% CI 2.8-4.0), and after adjustment for baseline characteristics and left ventricular systolic function in multivariate Cox proportional hazards analysis the risk was 2.1 (95% CI 1.7-2.6), P<0.0001.CONCLUSIONS: Congestive heart failure is frequently present in patients with preserved left ventricular systolic function, and is associated with increased risk of in-hospital complications and death following acute myocardial infarction.

KW - Aged

KW - Aged, 80 and over

KW - Blood Pressure

KW - Denmark

KW - Echocardiography

KW - Female

KW - Heart Failure

KW - Hospitalization

KW - Humans

KW - Male

KW - Mass Screening

KW - Middle Aged

KW - Myocardial Infarction

KW - Prevalence

KW - Prognosis

KW - Prospective Studies

KW - Survival Rate

KW - Ventricular Dysfunction, Left

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 14675860

VL - 5

SP - 811

EP - 819

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

IS - 6

ER -