Condensing the information in DNA with double-headed nucleotides

Mick Hornum, Pawan K Sharma, Charlotte Reslow-Jacobsen, Pawan Kumar, Michael Petersen, Poul Nielsen

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Abstrakt

A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind53
Udgave nummer70
Sider (fra-til)9717-9720
Antal sider4
ISSN1359-7345
DOI
StatusUdgivet - 2017

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