Condensing the information in DNA with double-headed nucleotides

Mick Hornum, Pawan K Sharma, Charlotte Reslow-Jacobsen, Pawan Kumar, Michael Petersen, Poul Nielsen

Publikation: Bidrag til tidsskriftLetterForskningpeer review

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Resumé

A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind53
Udgave nummer70
Sider (fra-til)9717-9720
Antal sider4
ISSN1359-7345
DOI
StatusUdgivet - 2017

Fingeraftryk

Nucleotides
DNA
Phosphates

Citer dette

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Condensing the information in DNA with double-headed nucleotides. / Hornum, Mick; Sharma, Pawan K; Reslow-Jacobsen, Charlotte; Kumar, Pawan; Petersen, Michael; Nielsen, Poul.

I: Chemical Communications, Bind 53, Nr. 70, 2017, s. 9717-9720.

Publikation: Bidrag til tidsskriftLetterForskningpeer review

TY - JOUR

T1 - Condensing the information in DNA with double-headed nucleotides

AU - Hornum, Mick

AU - Sharma, Pawan K

AU - Reslow-Jacobsen, Charlotte

AU - Kumar, Pawan

AU - Petersen, Michael

AU - Nielsen, Poul

PY - 2017

Y1 - 2017

N2 - A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.

AB - A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.

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U2 - 10.1039/c7cc05047j

DO - 10.1039/c7cc05047j

M3 - Letter

VL - 53

SP - 9717

EP - 9720

JO - Chemical Communications

JF - Chemical Communications

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