Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration

M Rumman, J Dhawan, Moustapha Kassem

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration
OriginalsprogEngelsk
TidsskriftStem Cells
Vol/bind33
Udgave nummer10
Sider (fra-til)2903-12
ISSN1066-5099
DOI
StatusUdgivet - 2015

    Fingerprint

Citationsformater