Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals

Martin Bonde Jensen, Casper Slots, Nicholas Ditzel, Ole Albrektsen, Søren Wiatr Borg, Torben Thygesen, Moustapha Kassem, Morten Østergaard Andersen*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

This paper introduces a novel class of resorbable implant materials based on composites of solid fatty acids and ceramic powders. The materials could be 3D printed and cast into implants that consisted of powder particles embedded in a dense and solid lipid matrix. The implants possessed 10x higher compressive strengths than pure fatty acids and their compressive strength, resorption speed and drug release rate could be controlled by varying the fatty acid tail length. The materials supported the attachment and growth of mesenchymal stem cells in vitro and when implanted in a subcutaneous mouse model they were found to be biocompatible and support the formation of cellularized and vascularized tissue in vivo. These results indicate that solid fatty acid/ceramic matrices may be used as a biomaterial for structural implants and controlled release drug depots providing an attractive alternative to the polymer based matrices commonly used for such implants.

OriginalsprogEngelsk
Artikelnummere00027
TidsskriftBioprinting
Vol/bind10
ISSN2405-8866
DOI
StatusUdgivet - jun. 2018

Fingeraftryk

Fatty acids
Biomaterials
Powders
Drug products
Fatty Acids
Compressive Strength
Composite materials
Pharmaceutical Preparations
Compressive strength
Stem cells
Mesenchymal Stromal Cells
Lipids
Tissue
Polymers
Growth
Drug Liberation

Citer dette

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title = "Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals",
abstract = "This paper introduces a novel class of resorbable implant materials based on composites of solid fatty acids and ceramic powders. The materials could be 3D printed and cast into implants that consisted of powder particles embedded in a dense and solid lipid matrix. The implants possessed 10x higher compressive strengths than pure fatty acids and their compressive strength, resorption speed and drug release rate could be controlled by varying the fatty acid tail length. The materials supported the attachment and growth of mesenchymal stem cells in vitro and when implanted in a subcutaneous mouse model they were found to be biocompatible and support the formation of cellularized and vascularized tissue in vivo. These results indicate that solid fatty acid/ceramic matrices may be used as a biomaterial for structural implants and controlled release drug depots providing an attractive alternative to the polymer based matrices commonly used for such implants.",
keywords = "3D printing, Additive manufacturing, Controlled release, Fatty acids, Scaffolds, Tricalcium phosphate",
author = "{Bonde Jensen}, Martin and Casper Slots and Nicholas Ditzel and Ole Albrektsen and {Wiatr Borg}, S{\o}ren and Torben Thygesen and Moustapha Kassem and Andersen, {Morten {\O}stergaard}",
year = "2018",
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language = "English",
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journal = "Bioprinting",
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publisher = "Elsevier",

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Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals. / Bonde Jensen, Martin; Slots, Casper; Ditzel, Nicholas; Albrektsen, Ole; Wiatr Borg, Søren ; Thygesen, Torben; Kassem, Moustapha; Andersen, Morten Østergaard.

I: Bioprinting, Bind 10, e00027, 06.2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals

AU - Bonde Jensen, Martin

AU - Slots, Casper

AU - Ditzel, Nicholas

AU - Albrektsen, Ole

AU - Wiatr Borg, Søren

AU - Thygesen, Torben

AU - Kassem, Moustapha

AU - Andersen, Morten Østergaard

PY - 2018/6

Y1 - 2018/6

N2 - This paper introduces a novel class of resorbable implant materials based on composites of solid fatty acids and ceramic powders. The materials could be 3D printed and cast into implants that consisted of powder particles embedded in a dense and solid lipid matrix. The implants possessed 10x higher compressive strengths than pure fatty acids and their compressive strength, resorption speed and drug release rate could be controlled by varying the fatty acid tail length. The materials supported the attachment and growth of mesenchymal stem cells in vitro and when implanted in a subcutaneous mouse model they were found to be biocompatible and support the formation of cellularized and vascularized tissue in vivo. These results indicate that solid fatty acid/ceramic matrices may be used as a biomaterial for structural implants and controlled release drug depots providing an attractive alternative to the polymer based matrices commonly used for such implants.

AB - This paper introduces a novel class of resorbable implant materials based on composites of solid fatty acids and ceramic powders. The materials could be 3D printed and cast into implants that consisted of powder particles embedded in a dense and solid lipid matrix. The implants possessed 10x higher compressive strengths than pure fatty acids and their compressive strength, resorption speed and drug release rate could be controlled by varying the fatty acid tail length. The materials supported the attachment and growth of mesenchymal stem cells in vitro and when implanted in a subcutaneous mouse model they were found to be biocompatible and support the formation of cellularized and vascularized tissue in vivo. These results indicate that solid fatty acid/ceramic matrices may be used as a biomaterial for structural implants and controlled release drug depots providing an attractive alternative to the polymer based matrices commonly used for such implants.

KW - 3D printing

KW - Additive manufacturing

KW - Controlled release

KW - Fatty acids

KW - Scaffolds

KW - Tricalcium phosphate

U2 - 10.1016/j.bprint.2018.e00027

DO - 10.1016/j.bprint.2018.e00027

M3 - Journal article

AN - SCOPUS:85052987667

VL - 10

JO - Bioprinting

JF - Bioprinting

SN - 2405-8866

M1 - e00027

ER -