Complexity in subnetworks of a peroxidase-oxidase reaction model

Jason A.C. Gallas*, Lars F. Olsen


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The peroxidase-oxidase (PO) reaction is a paradigmatic (bio)chemical system well suited to study the organization and stability of self-sustained oscillatory phases typically present in nonlinear systems. The PO reaction can be simulated by the state-of-the-art Bronnikova-Fedkina-Schaffer-Olsen model involving ten coupled ordinary differential equations. The complex and dynamically rich distribution of self-sustained oscillatory stability phases of this model was recently investigated in detail. However, would it be possible to understand aspects of such a complex model using much simpler models? Here, we investigate stability phases predicted by three simple four-variable subnetworks derived from the complete model. While stability diagrams for such subnetworks are found to be distorted compared to those of the complete model, we find them to surprisingly preserve significant features of the original model as well as from the experimental system, e.g., period-doubling and period-adding scenarios. In addition, return maps obtained from the subnetworks look very similar to maps obtained in the experimental system under different conditions. Finally, two of the three subnetwork models are found to exhibit quint points, i.e., recently reported singular points where five distinct stability phases coalesce. We also provide experimental evidence that such quint points are present in the PO reaction.

Udgave nummer6
StatusUdgivet - jun. 2022

Bibliografisk note

Funding Information:
L.F.O. wishes to thank Anita Lunding for help with the experiments. J.A.C.G. was supported in part by CNPq, Brazil (Grant No. PQ-305305/2020-4). All bitmaps were computed at the CESUP-UFRGS Supercomputer Center of the Federal University in Porto Alegre, Brazil.

Publisher Copyright:
© 2022 Author(s).


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