Comparison of tenoxicam by intramuscular injection or wound infiltration for analgesia after inguinal herniorrhaphy

S S Mikkelsen, K E Knudsen, B B Kristensen, M U Linnemann, E Friis, J B Dahl

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We compared wound infiltration with small-dose tenoxicam (7.5 mg) to intramuscular (IM) administration of the same dose to treat pain after herniorrhaphy. In a randomized, double-blind study, 50 patients received either preoperative wound infiltration with tenoxicam, 7.5 mg in 40 mL of 0.9% saline (WI group; n = 25) or IM tenoxicam 7.5 mg (IM group; n = 25). In each group a saline placebo of equal volume was given by the alternate route, i.e., those who received wound infiltration with tenoxicam received 0.75 mL of 0.9% saline IM; those who received IM tenoxicam received 40 mL of 0.9% saline for wound infiltration. Postoperative pain was assessed with a verbal pain scale and a visual analog scale (VAS) at rest and during movement and cough, 1, 2, 4, 6, and 24 h postoperatively. Wound tenderness was assessed with an electronic algometer preoperatively, and 2, 4, and 6 h postoperatively. The need for supplementary analgesics (acetaminophen and morphine) was registered. No differences were observed between groups in VAS pain scores, verbal rating pain scores, pain pressure thresholds, or in need for supplementary analgesics. We conclude that tenoxicam 7.5 mg has no local analgesic effect on postoperative pain after herniorrhaphy.

OriginalsprogEngelsk
TidsskriftAnesthesia and Analgesia
Vol/bind83
Udgave nummer6
Sider (fra-til)1239-43
Antal sider5
ISSN0003-2999
StatusUdgivet - dec. 1996
Udgivet eksterntJa

Fingeraftryk

tenoxicam
Groin
Herniorrhaphy
Intramuscular Injections
Wounds and Injuries
Pain Threshold
Pain Measurement
Acetaminophen
Visual Analog Scale
Double-Blind Method
Cough
Morphine
Placebos

Citer dette

Mikkelsen, S. S., Knudsen, K. E., Kristensen, B. B., Linnemann, M. U., Friis, E., & Dahl, J. B. (1996). Comparison of tenoxicam by intramuscular injection or wound infiltration for analgesia after inguinal herniorrhaphy. Anesthesia and Analgesia, 83(6), 1239-43.
Mikkelsen, S S ; Knudsen, K E ; Kristensen, B B ; Linnemann, M U ; Friis, E ; Dahl, J B. / Comparison of tenoxicam by intramuscular injection or wound infiltration for analgesia after inguinal herniorrhaphy. I: Anesthesia and Analgesia. 1996 ; Bind 83, Nr. 6. s. 1239-43.
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abstract = "We compared wound infiltration with small-dose tenoxicam (7.5 mg) to intramuscular (IM) administration of the same dose to treat pain after herniorrhaphy. In a randomized, double-blind study, 50 patients received either preoperative wound infiltration with tenoxicam, 7.5 mg in 40 mL of 0.9{\%} saline (WI group; n = 25) or IM tenoxicam 7.5 mg (IM group; n = 25). In each group a saline placebo of equal volume was given by the alternate route, i.e., those who received wound infiltration with tenoxicam received 0.75 mL of 0.9{\%} saline IM; those who received IM tenoxicam received 40 mL of 0.9{\%} saline for wound infiltration. Postoperative pain was assessed with a verbal pain scale and a visual analog scale (VAS) at rest and during movement and cough, 1, 2, 4, 6, and 24 h postoperatively. Wound tenderness was assessed with an electronic algometer preoperatively, and 2, 4, and 6 h postoperatively. The need for supplementary analgesics (acetaminophen and morphine) was registered. No differences were observed between groups in VAS pain scores, verbal rating pain scores, pain pressure thresholds, or in need for supplementary analgesics. We conclude that tenoxicam 7.5 mg has no local analgesic effect on postoperative pain after herniorrhaphy.",
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Mikkelsen, SS, Knudsen, KE, Kristensen, BB, Linnemann, MU, Friis, E & Dahl, JB 1996, 'Comparison of tenoxicam by intramuscular injection or wound infiltration for analgesia after inguinal herniorrhaphy', Anesthesia and Analgesia, bind 83, nr. 6, s. 1239-43.

Comparison of tenoxicam by intramuscular injection or wound infiltration for analgesia after inguinal herniorrhaphy. / Mikkelsen, S S; Knudsen, K E; Kristensen, B B; Linnemann, M U; Friis, E; Dahl, J B.

I: Anesthesia and Analgesia, Bind 83, Nr. 6, 12.1996, s. 1239-43.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Comparison of tenoxicam by intramuscular injection or wound infiltration for analgesia after inguinal herniorrhaphy

AU - Mikkelsen, S S

AU - Knudsen, K E

AU - Kristensen, B B

AU - Linnemann, M U

AU - Friis, E

AU - Dahl, J B

PY - 1996/12

Y1 - 1996/12

N2 - We compared wound infiltration with small-dose tenoxicam (7.5 mg) to intramuscular (IM) administration of the same dose to treat pain after herniorrhaphy. In a randomized, double-blind study, 50 patients received either preoperative wound infiltration with tenoxicam, 7.5 mg in 40 mL of 0.9% saline (WI group; n = 25) or IM tenoxicam 7.5 mg (IM group; n = 25). In each group a saline placebo of equal volume was given by the alternate route, i.e., those who received wound infiltration with tenoxicam received 0.75 mL of 0.9% saline IM; those who received IM tenoxicam received 40 mL of 0.9% saline for wound infiltration. Postoperative pain was assessed with a verbal pain scale and a visual analog scale (VAS) at rest and during movement and cough, 1, 2, 4, 6, and 24 h postoperatively. Wound tenderness was assessed with an electronic algometer preoperatively, and 2, 4, and 6 h postoperatively. The need for supplementary analgesics (acetaminophen and morphine) was registered. No differences were observed between groups in VAS pain scores, verbal rating pain scores, pain pressure thresholds, or in need for supplementary analgesics. We conclude that tenoxicam 7.5 mg has no local analgesic effect on postoperative pain after herniorrhaphy.

AB - We compared wound infiltration with small-dose tenoxicam (7.5 mg) to intramuscular (IM) administration of the same dose to treat pain after herniorrhaphy. In a randomized, double-blind study, 50 patients received either preoperative wound infiltration with tenoxicam, 7.5 mg in 40 mL of 0.9% saline (WI group; n = 25) or IM tenoxicam 7.5 mg (IM group; n = 25). In each group a saline placebo of equal volume was given by the alternate route, i.e., those who received wound infiltration with tenoxicam received 0.75 mL of 0.9% saline IM; those who received IM tenoxicam received 40 mL of 0.9% saline for wound infiltration. Postoperative pain was assessed with a verbal pain scale and a visual analog scale (VAS) at rest and during movement and cough, 1, 2, 4, 6, and 24 h postoperatively. Wound tenderness was assessed with an electronic algometer preoperatively, and 2, 4, and 6 h postoperatively. The need for supplementary analgesics (acetaminophen and morphine) was registered. No differences were observed between groups in VAS pain scores, verbal rating pain scores, pain pressure thresholds, or in need for supplementary analgesics. We conclude that tenoxicam 7.5 mg has no local analgesic effect on postoperative pain after herniorrhaphy.

KW - Abdomen/surgery

KW - Acetaminophen/administration & dosage

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Analgesia/methods

KW - Analgesics, Non-Narcotic/administration & dosage

KW - Analgesics, Opioid/administration & dosage

KW - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage

KW - Double-Blind Method

KW - Female

KW - Hernia, Inguinal/surgery

KW - Humans

KW - Injections, Intradermal

KW - Injections, Intramuscular

KW - Male

KW - Middle Aged

KW - Morphine/administration & dosage

KW - Movement

KW - Pain Measurement

KW - Pain Threshold/drug effects

KW - Pain, Postoperative/drug therapy

KW - Piroxicam/administration & dosage

KW - Placebos

KW - Rest

M3 - Journal article

VL - 83

SP - 1239

EP - 1243

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 6

ER -

Mikkelsen SS, Knudsen KE, Kristensen BB, Linnemann MU, Friis E, Dahl JB. Comparison of tenoxicam by intramuscular injection or wound infiltration for analgesia after inguinal herniorrhaphy. Anesthesia and Analgesia. 1996 dec;83(6):1239-43.