Comparison of intraprostatic ethanol diffusion using a microporous hollow fiber catheter versus a standard needle

Benjamin J King, Mark K Plante, Masatoshi Kida, Travis K Mann-Gow, Rick Odland, Peter Zvara

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

PURPOSE: Transurethral intraprostatic ethanol chemoablation of the prostate has shown promising preliminary clinical results for benign prostatic hyperplasia with some variability in clinical outcome. This is likely due to the uneven prostate diffusion caused by varying resistance of the tissue type in which the tip of the needle is embedded. We examined whether the distribution of the injectable in the canine prostate could be improved using a microporous hollow fiber catheter (Twin Star Medical, Minneapolis, Minnesota).

MATERIALS AND METHODS: The prostate was exposed in 9 mongrel dogs. A single injection of 98% ethanol was delivered in each lobe using a microporous hollow fiber catheter and a standard needle. Prostates were harvested and fixed in 10% formalin. After injection 2.5 mm step sections were obtained and scanned. The ethanol induced tissue lesions were traced on hematoxylin and eosin sections. Three-dimensional reconstructions were created and the volume of each prostate lesion was calculated using stereology.

RESULTS: Ethanol induced tissue changes were seen bilaterally in 8 of 9 ethanol injected prostates. In all cases the lesion created by microporous hollow fiber catheter injection was larger than that in the contralateral lobe injected with the control needle. When data were pooled, the hollow fiber catheter injection produced significantly greater tissue changes than the control needle injection (p = 0.03).

CONCLUSIONS: Improved distribution and absent backflow were seen when using the microporous hollow fiber catheter, supporting its potential as a new method to treat prostate disease.

OriginalsprogEngelsk
TidsskriftThe Journal of Urology (Italian Edition)
Vol/bind187
Udgave nummer5
Sider (fra-til)1898-1902
Antal sider5
ISSN1828-6593
DOI
StatusUdgivet - maj 2012
Udgivet eksterntJa

Fingeraftryk

Needles
Prostate
Ethanol
Catheters
Prostatic Hyperplasia
Hematoxylin
Eosine Yellowish-(YS)
Formaldehyde
Dogs

Citer dette

King, Benjamin J ; Plante, Mark K ; Kida, Masatoshi ; Mann-Gow, Travis K ; Odland, Rick ; Zvara, Peter. / Comparison of intraprostatic ethanol diffusion using a microporous hollow fiber catheter versus a standard needle. I: The Journal of Urology (Italian Edition). 2012 ; Bind 187, Nr. 5. s. 1898-1902.
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title = "Comparison of intraprostatic ethanol diffusion using a microporous hollow fiber catheter versus a standard needle",
abstract = "PURPOSE: Transurethral intraprostatic ethanol chemoablation of the prostate has shown promising preliminary clinical results for benign prostatic hyperplasia with some variability in clinical outcome. This is likely due to the uneven prostate diffusion caused by varying resistance of the tissue type in which the tip of the needle is embedded. We examined whether the distribution of the injectable in the canine prostate could be improved using a microporous hollow fiber catheter (Twin Star Medical, Minneapolis, Minnesota).MATERIALS AND METHODS: The prostate was exposed in 9 mongrel dogs. A single injection of 98{\%} ethanol was delivered in each lobe using a microporous hollow fiber catheter and a standard needle. Prostates were harvested and fixed in 10{\%} formalin. After injection 2.5 mm step sections were obtained and scanned. The ethanol induced tissue lesions were traced on hematoxylin and eosin sections. Three-dimensional reconstructions were created and the volume of each prostate lesion was calculated using stereology.RESULTS: Ethanol induced tissue changes were seen bilaterally in 8 of 9 ethanol injected prostates. In all cases the lesion created by microporous hollow fiber catheter injection was larger than that in the contralateral lobe injected with the control needle. When data were pooled, the hollow fiber catheter injection produced significantly greater tissue changes than the control needle injection (p = 0.03).CONCLUSIONS: Improved distribution and absent backflow were seen when using the microporous hollow fiber catheter, supporting its potential as a new method to treat prostate disease.",
keywords = "Animals, Catheter Ablation/instrumentation, Catheters, Dogs, Equipment Design, Ethanol/administration & dosage, Injections, Intralesional, Male, Needles, Prostate/metabolism, Solvents/administration & dosage",
author = "King, {Benjamin J} and Plante, {Mark K} and Masatoshi Kida and Mann-Gow, {Travis K} and Rick Odland and Peter Zvara",
note = "Copyright {\circledC} 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.",
year = "2012",
month = "5",
doi = "10.1016/j.juro.2011.12.057",
language = "English",
volume = "187",
pages = "1898--1902",
journal = "The Journal of Urology (Italian Edition)",
issn = "1828-6593",
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number = "5",

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Comparison of intraprostatic ethanol diffusion using a microporous hollow fiber catheter versus a standard needle. / King, Benjamin J; Plante, Mark K; Kida, Masatoshi; Mann-Gow, Travis K; Odland, Rick; Zvara, Peter.

I: The Journal of Urology (Italian Edition), Bind 187, Nr. 5, 05.2012, s. 1898-1902.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Comparison of intraprostatic ethanol diffusion using a microporous hollow fiber catheter versus a standard needle

AU - King, Benjamin J

AU - Plante, Mark K

AU - Kida, Masatoshi

AU - Mann-Gow, Travis K

AU - Odland, Rick

AU - Zvara, Peter

N1 - Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2012/5

Y1 - 2012/5

N2 - PURPOSE: Transurethral intraprostatic ethanol chemoablation of the prostate has shown promising preliminary clinical results for benign prostatic hyperplasia with some variability in clinical outcome. This is likely due to the uneven prostate diffusion caused by varying resistance of the tissue type in which the tip of the needle is embedded. We examined whether the distribution of the injectable in the canine prostate could be improved using a microporous hollow fiber catheter (Twin Star Medical, Minneapolis, Minnesota).MATERIALS AND METHODS: The prostate was exposed in 9 mongrel dogs. A single injection of 98% ethanol was delivered in each lobe using a microporous hollow fiber catheter and a standard needle. Prostates were harvested and fixed in 10% formalin. After injection 2.5 mm step sections were obtained and scanned. The ethanol induced tissue lesions were traced on hematoxylin and eosin sections. Three-dimensional reconstructions were created and the volume of each prostate lesion was calculated using stereology.RESULTS: Ethanol induced tissue changes were seen bilaterally in 8 of 9 ethanol injected prostates. In all cases the lesion created by microporous hollow fiber catheter injection was larger than that in the contralateral lobe injected with the control needle. When data were pooled, the hollow fiber catheter injection produced significantly greater tissue changes than the control needle injection (p = 0.03).CONCLUSIONS: Improved distribution and absent backflow were seen when using the microporous hollow fiber catheter, supporting its potential as a new method to treat prostate disease.

AB - PURPOSE: Transurethral intraprostatic ethanol chemoablation of the prostate has shown promising preliminary clinical results for benign prostatic hyperplasia with some variability in clinical outcome. This is likely due to the uneven prostate diffusion caused by varying resistance of the tissue type in which the tip of the needle is embedded. We examined whether the distribution of the injectable in the canine prostate could be improved using a microporous hollow fiber catheter (Twin Star Medical, Minneapolis, Minnesota).MATERIALS AND METHODS: The prostate was exposed in 9 mongrel dogs. A single injection of 98% ethanol was delivered in each lobe using a microporous hollow fiber catheter and a standard needle. Prostates were harvested and fixed in 10% formalin. After injection 2.5 mm step sections were obtained and scanned. The ethanol induced tissue lesions were traced on hematoxylin and eosin sections. Three-dimensional reconstructions were created and the volume of each prostate lesion was calculated using stereology.RESULTS: Ethanol induced tissue changes were seen bilaterally in 8 of 9 ethanol injected prostates. In all cases the lesion created by microporous hollow fiber catheter injection was larger than that in the contralateral lobe injected with the control needle. When data were pooled, the hollow fiber catheter injection produced significantly greater tissue changes than the control needle injection (p = 0.03).CONCLUSIONS: Improved distribution and absent backflow were seen when using the microporous hollow fiber catheter, supporting its potential as a new method to treat prostate disease.

KW - Animals

KW - Catheter Ablation/instrumentation

KW - Catheters

KW - Dogs

KW - Equipment Design

KW - Ethanol/administration & dosage

KW - Injections, Intralesional

KW - Male

KW - Needles

KW - Prostate/metabolism

KW - Solvents/administration & dosage

U2 - 10.1016/j.juro.2011.12.057

DO - 10.1016/j.juro.2011.12.057

M3 - Journal article

VL - 187

SP - 1898

EP - 1902

JO - The Journal of Urology (Italian Edition)

JF - The Journal of Urology (Italian Edition)

SN - 1828-6593

IS - 5

ER -