Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

Fergus J Couch; Mia M Gaudet; Antonis C Antoniou; Susan J Ramus; Karoline B Kuchenbaecker; Penny Soucy; Jonathan Beesley; Xiaoqing Chen; Xianshu Wang; Tomas Kirchhoff; Lesley McGuffog; Daniel Barrowdale; Andrew Lee; Sue Healey; Olga M Sinilnikova; Irene L Andrulis; Hilmi Ozcelik; Anna Marie Mulligan; Mads Thomassen; Anne-Marie Gerdes; Uffe Birk Jensen; Anne-Bine Skytte; Torben A Kruse; Maria A Caligo; Anna von Wachenfeldt; Gisela Barbany-Bustinza; Niklas Loman; Maria Soller; Hans Ehrencrona; Per Karlsson; Katherine L Nathanson; Timothy R Rebbeck; Susan M Domchek; Ania Jakubowska; Jan Lubinski; Katarzyna Jaworska; Katarzyna Durda; Elzbieta Zlowocka; Tomasz Huzarski; Tomasz Byrski; Jacek Gronwald; Cezary Cybulski; Bohdan Górski; Ana Osorio; Mercedes Durán; María Isabel Tejada; Javier Benitez; Ute Hamann; Frans B L Hogervorst; Theo A van Os; OCGN

doi:10.1158/1055-9965.EPI-11-0888

Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

Fergus J Couch, Mia M Gaudet, Antonis C Antoniou, Susan J Ramus, Karoline B Kuchenbaecker, Penny Soucy, Jonathan Beesley, Xiaoqing Chen, Xianshu Wang, Tomas Kirchhoff, Lesley McGuffog, Daniel Barrowdale, Andrew Lee, Sue Healey, Olga M Sinilnikova, Irene L Andrulis, Hilmi Ozcelik, Anna Marie Mulligan, Mads Thomassen, Anne-Marie GerdesUffe Birk Jensen, Anne-Bine Skytte, Torben A Kruse, Maria A Caligo, Anna von Wachenfeldt, Gisela Barbany-Bustinza, Niklas Loman, Maria Soller, Hans Ehrencrona, Per Karlsson, Katherine L Nathanson, Timothy R Rebbeck, Susan M Domchek, Ania Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna Durda, Elzbieta Zlowocka, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Cezary Cybulski, Bohdan Górski, Ana Osorio, Mercedes Durán, María Isabel Tejada, Javier Benitez, Ute Hamann, Frans B L Hogervorst, Theo A van Os, OCGN

KI, OUH, Forskningsenhed for Human Genetik (Odense)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

Originalsprog	Engelsk
Tidsskrift	Cancer Epidemiology, Biomarkers & Prevention
Vol/bind	21
Udgave nummer	4
Sider (fra-til)	645-57
Antal sider	13
DOI	https://doi.org/10.1158/1055-9965.EPI-11-0888
Status	Udgivet - 2012

Dokumenter og links

10.1158/1055-9965.EPI-11-0888

Citationsformater

Couch, F. J., Gaudet, M. M., Antoniou, A. C., Ramus, S. J., Kuchenbaecker, K. B., Soucy, P., Beesley, J., Chen, X., Wang, X., Kirchhoff, T., McGuffog, L., Barrowdale, D., Lee, A., Healey, S., Sinilnikova, O. M., Andrulis, I. L., Ozcelik, H., Mulligan, A. M., Thomassen, M., ... OCGN (2012). Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention, 21(4), 645-57. https://doi.org/10.1158/1055-9965.EPI-11-0888

@article{70246a0a50fa44149ab913307f826f17,

title = "Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers",

abstract = "Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).",

keywords = "Adult, Aged, BRCA1 Protein, BRCA2 Protein, Breast Neoplasms, Chromosomes, Human, Pair 19, DNA-Binding Proteins, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Immunoenzyme Techniques, Middle Aged, Mutation, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Prognosis, Receptors, Estrogen, Risk Factors, Transcription Factors, United States",

author = "Couch, {Fergus J} and Gaudet, {Mia M} and Antoniou, {Antonis C} and Ramus, {Susan J} and Kuchenbaecker, {Karoline B} and Penny Soucy and Jonathan Beesley and Xiaoqing Chen and Xianshu Wang and Tomas Kirchhoff and Lesley McGuffog and Daniel Barrowdale and Andrew Lee and Sue Healey and Sinilnikova, {Olga M} and Andrulis, {Irene L} and Hilmi Ozcelik and Mulligan, {Anna Marie} and Mads Thomassen and Anne-Marie Gerdes and Jensen, {Uffe Birk} and Anne-Bine Skytte and Kruse, {Torben A} and Caligo, {Maria A} and {von Wachenfeldt}, Anna and Gisela Barbany-Bustinza and Niklas Loman and Maria Soller and Hans Ehrencrona and Per Karlsson and Nathanson, {Katherine L} and Rebbeck, {Timothy R} and Domchek, {Susan M} and Ania Jakubowska and Jan Lubinski and Katarzyna Jaworska and Katarzyna Durda and Elzbieta Zlowocka and Tomasz Huzarski and Tomasz Byrski and Jacek Gronwald and Cezary Cybulski and Bohdan G{\'o}rski and Ana Osorio and Mercedes Dur{\'a}n and Tejada, {Mar{\'i}a Isabel} and Javier Benitez and Ute Hamann and Hogervorst, {Frans B L} and {van Os}, {Theo A} and OCGN",

note = "{\textcopyright}2012 AACR.",

year = "2012",

doi = "10.1158/1055-9965.EPI-11-0888",

language = "English",

volume = "21",

pages = "645--57",

journal = "Cancer Epidemiology, Biomarkers & Prevention",

issn = "1538-7755",

publisher = "American Association for Cancer Research",

number = "4",

}

Couch, FJ, Gaudet, MM, Antoniou, AC, Ramus, SJ, Kuchenbaecker, KB, Soucy, P, Beesley, J, Chen, X, Wang, X, Kirchhoff, T, McGuffog, L, Barrowdale, D, Lee, A, Healey, S, Sinilnikova, OM, Andrulis, IL, Ozcelik, H, Mulligan, AM, Thomassen, M, Gerdes, A-M, Jensen, UB, Skytte, A-B, Kruse, TA, Caligo, MA, von Wachenfeldt, A, Barbany-Bustinza, G, Loman, N, Soller, M, Ehrencrona, H, Karlsson, P, Nathanson, KL, Rebbeck, TR, Domchek, SM, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Zlowocka, E, Huzarski, T, Byrski, T, Gronwald, J, Cybulski, C, Górski, B, Osorio, A, Durán, M, Tejada, MI, Benitez, J, Hamann, U, Hogervorst, FBL, van Os, TA & OCGN 2012, 'Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers', Cancer Epidemiology, Biomarkers & Prevention, bind 21, nr. 4, s. 645-57. https://doi.org/10.1158/1055-9965.EPI-11-0888

Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. / Couch, Fergus J; Gaudet, Mia M; Antoniou, Antonis C et al.
I: Cancer Epidemiology, Biomarkers & Prevention, Bind 21, Nr. 4, 2012, s. 645-57.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

AU - Couch, Fergus J

AU - Gaudet, Mia M

AU - Antoniou, Antonis C

AU - Ramus, Susan J

AU - Kuchenbaecker, Karoline B

AU - Soucy, Penny

AU - Beesley, Jonathan

AU - Chen, Xiaoqing

AU - Wang, Xianshu

AU - Kirchhoff, Tomas

AU - McGuffog, Lesley

AU - Barrowdale, Daniel

AU - Lee, Andrew

AU - Healey, Sue

AU - Sinilnikova, Olga M

AU - Andrulis, Irene L

AU - Ozcelik, Hilmi

AU - Mulligan, Anna Marie

AU - Thomassen, Mads

AU - Gerdes, Anne-Marie

AU - Jensen, Uffe Birk

AU - Skytte, Anne-Bine

AU - Kruse, Torben A

AU - Caligo, Maria A

AU - von Wachenfeldt, Anna

AU - Barbany-Bustinza, Gisela

AU - Loman, Niklas

AU - Soller, Maria

AU - Ehrencrona, Hans

AU - Karlsson, Per

AU - Nathanson, Katherine L

AU - Rebbeck, Timothy R

AU - Domchek, Susan M

AU - Jakubowska, Ania

AU - Lubinski, Jan

AU - Jaworska, Katarzyna

AU - Durda, Katarzyna

AU - Zlowocka, Elzbieta

AU - Huzarski, Tomasz

AU - Byrski, Tomasz

AU - Gronwald, Jacek

AU - Cybulski, Cezary

AU - Górski, Bohdan

AU - Osorio, Ana

AU - Durán, Mercedes

AU - Tejada, María Isabel

AU - Benitez, Javier

AU - Hamann, Ute

AU - Hogervorst, Frans B L

AU - van Os, Theo A

AU - OCGN

PY - 2012

Y1 - 2012

N2 - Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

AB - Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

KW - Adult

KW - Aged

KW - BRCA1 Protein

KW - BRCA2 Protein

KW - Breast Neoplasms

KW - Chromosomes, Human, Pair 19

KW - DNA-Binding Proteins

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Immunoenzyme Techniques

KW - Middle Aged

KW - Mutation

KW - Ovarian Neoplasms

KW - Polymorphism, Single Nucleotide

KW - Prognosis

KW - Receptors, Estrogen

KW - Risk Factors

KW - Transcription Factors

KW - United States

U2 - 10.1158/1055-9965.EPI-11-0888

DO - 10.1158/1055-9965.EPI-11-0888

M3 - Journal article

C2 - 22351618

SN - 1538-7755

VL - 21

SP - 645

EP - 657

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

IS - 4

ER -

Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

Abstract

Dokumenter og links

Fingeraftryk

Citationsformater