@article{fd773b60bcac11deab49000ea68e967b,
title = "Common type 2 diabetes risk gene variants associate with gestational diabetes",
abstract = "OBJECTIVE: We aimed to examine the association between gestational diabetes mellitus (GDM) and 11 recently identified type 2 diabetes susceptibility loci. RESEARCH DESIGN AND METHODS: Type 2 diabetes risk variants in TCF7L2, CDKAL1, SLC30A8, HHEX/IDE, CDKN2A/2B, IGF2BP2, FTO, TCF2, PPARG, KCNJ11, and WFS1 loci were genotyped in a cohort of women with a history of GDM (n = 283) and glucose-tolerant women of the population-based Inter99 cohort (n = 2446). RESULTS: All the risk alleles in the 11 examined type 2 diabetes risk variants showed an odds ratio (OR) greater than 1 for the GDM group compared with the control group ranging from 1.13 [95\% confidence interval (CI) 0.88-1.46] to 1.44 (95\% CI 1.19-1.74) except for the WFS1 rs10010131 variant with OR 0.87 (95\% CI 0.73-1.05). Combined analysis of all 11 variants showed a highly significant additive effect of multiple risk alleles on risk of GDM [OR 1.18 (95\% CI 1.10-1.27)] per risk allele, P = 3.2 x 10(-6)). Applying receiver-operating characteristic showed an area under the receiver-operating characteristic curve of 0.62 for the genetic test alone and 0.73 when combining information on age, body mass index, and genotypes of the 11 gene variants. CONCLUSIONS: The prevalence in a prior GDM group of several previously proven type 2 diabetes risk alleles equals the findings from association studies on type 2 diabetes. This supports the hypothesis that GDM and type 2 diabetes are two of the same entity.",
keywords = "Adult, Body Mass Index, Cohort Studies, Diabetes Mellitus, Type 2, Diabetes, Gestational, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Pregnancy, ROC Curve, Risk",
author = "Jeannet Lauenborg and Niels Grarup and Peter Damm and Knut Borch-Johnsen and Torben J{\o}rgensen and Oluf Pedersen and Torben Hansen",
year = "2009",
month = jan,
day = "1",
doi = "10.1210/jc.2008-1336",
language = "English",
volume = "94",
pages = "145--50",
journal = "The Journal of Clinical Endocrinology \& Metabolism",
issn = "0021-972X",
publisher = "Endocrine Society",
number = "1",
}