Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

Lawrence J. Cook, John W. Rose, Jessica S. Alvey, Anna Marie Jolley, Renee Kuhn, Brie Marron, Melissa Pederson, Rene Enriquez, Jeff Yearley, Stephen McKechnie, May H. Han, Anna J. Tomczak, Michael Levy, Maureen A. Mealy, Jessica Coleman, Jeffrey L. Bennett, Ruth Johnson, Myka Barnes-Garcia, Anthony L. Traboulsee, Robert L. CarruthersLisa Eunyoung Lee, Julia J. Schubert, Katrina McMullen, Ilya Kister, Zoe Rimler, Allyson Reid, Nancy L. Sicotte, Sarah M. Planchon, Jeffrey A. Cohen, Diane Ivancic, Jennifer L. Sedlak, Ilana Katz Sand, Pavle Repovic, Lilyana Amezcua, Ana Pruitt, Erika Amundson, Tanuja Chitnis, Devin S. Mullin, Eric C. Klawiter, Andrew W. Russo, Claire S. Riley, Kaho B. Onomichi, Libby Levine, Katherine E. Nelson, Nancy M. Nealon, Casey Engel, Mason Kruse-Hoyer, Melanie Marcille, Leticia Tornes, Anne Rumpf, Angela Greer, Megan Kenneally Behne, Renee R. Rodriguez, Daniel W. Behne, Derek W. Blackway, Brian Coords, Terrence F. Blaschke, Judy Sheard, Terry J. Smith, Jacinta M. Behne, Michael R. Yeaman, The Guthy-Jackson Charitable Foundation International Clinical Consortium (GJCF–ICC), Nasrin Asgari (Medlem af forfattergruppering)

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ObjectiveTo develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment.MethodsTo illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks.ResultsAs of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.5% of the NMOSD cases and 71.7% of the controls continue in active follow-up. Consanguineous relatives of patients with NMOSD represented 43.6% of the control cohort. Of the 599 active cases with complete data, 84% were female, and 76% were anti-AQP4 seropositive. The majority were white/Caucasian (52.6%), whereas blacks/African Americans accounted for 23.5%, Hispanics/Latinos 12.4%, and Asians accounted for 9.0%. The median age at disease onset was 38.4 years, with a median ARR of 0.5. Seropositive cases were older at disease onset, more likely to be black/African American or Hispanic/Latino, and more likely to be female.ConclusionsCollectively, the CIRCLES experience to date demonstrates this study to be a useful and readily accessible resource to facilitate accelerating solutions for patients with NMOSD.

TidsskriftNeurology: Neuroimmunology & Neuroinflammation
Udgave nummer5
Antal sider17
StatusUdgivet - sep. 2019


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