Cold urticaria patients exhibit normal skin levels of functional mast cells and histamine after tolerance induction

Line Kring Tannert, Per Stahl Skov, Louise Bjerremann Jensen, Marcus Maurer, Carsten Bindslev-Jensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Cold urticaria is a skin condition characterized by rapid appearance of itchy wheals and occasionally angioedema in response to cold stimulation. Antihistamines do not sufficiently protect all patients from symptoms, even when used in higher than standard doses. In these patients, desensitization to cold can be beneficial. The aim was to investigate whether desensitization can lower temperature thresholds and reduce release of histamine in the skin. Cold urticaria patients were subjected to desensitization and assessed for skin responses to cold stimulation and codeine before and after. Histamine levels mediated by cold and codeine were determined by cutaneous microdialysis before and after desensitization in patients and healthy controls. Desensitization to cold resulted in protection from cold-induced symptoms and lower temperature thresholds in six out of nine patients. Desensitization also prevented histamine release after skin exposure to cold. Surprisingly, skin histamine levels and release after codeine injection were found to be normal in desensitized patients.
OriginalsprogEngelsk
TidsskriftDermatology
Vol/bind224
Udgave nummer2
Sider (fra-til)101-105
ISSN1018-8665
DOI
StatusUdgivet - 2012

Fingeraftryk

Urticaria
Mast Cells
Skin
Histamine Release
Histamine Antagonists
Microdialysis

Citer dette

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title = "Cold urticaria patients exhibit normal skin levels of functional mast cells and histamine after tolerance induction",
abstract = "Cold urticaria is a skin condition characterized by rapid appearance of itchy wheals and occasionally angioedema in response to cold stimulation. Antihistamines do not sufficiently protect all patients from symptoms, even when used in higher than standard doses. In these patients, desensitization to cold can be beneficial. The aim was to investigate whether desensitization can lower temperature thresholds and reduce release of histamine in the skin. Cold urticaria patients were subjected to desensitization and assessed for skin responses to cold stimulation and codeine before and after. Histamine levels mediated by cold and codeine were determined by cutaneous microdialysis before and after desensitization in patients and healthy controls. Desensitization to cold resulted in protection from cold-induced symptoms and lower temperature thresholds in six out of nine patients. Desensitization also prevented histamine release after skin exposure to cold. Surprisingly, skin histamine levels and release after codeine injection were found to be normal in desensitized patients.",
keywords = "Adolescent, Adult, Codeine, Cold Temperature, Desensitization, Immunologic, Female, Histamine Release, Humans, Immune Tolerance, Male, Mast Cells, Middle Aged, Treatment Outcome, Urticaria, Young Adult",
author = "{Kring Tannert}, Line and {Stahl Skov}, Per and {Bjerremann Jensen}, Louise and Marcus Maurer and Carsten Bindslev-Jensen",
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year = "2012",
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Cold urticaria patients exhibit normal skin levels of functional mast cells and histamine after tolerance induction. / Kring Tannert, Line; Stahl Skov, Per; Bjerremann Jensen, Louise; Maurer, Marcus; Bindslev-Jensen, Carsten.

I: Dermatology, Bind 224, Nr. 2, 2012, s. 101-105.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cold urticaria patients exhibit normal skin levels of functional mast cells and histamine after tolerance induction

AU - Kring Tannert, Line

AU - Stahl Skov, Per

AU - Bjerremann Jensen, Louise

AU - Maurer, Marcus

AU - Bindslev-Jensen, Carsten

N1 - Copyright © 2012 S. Karger AG, Basel.

PY - 2012

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N2 - Cold urticaria is a skin condition characterized by rapid appearance of itchy wheals and occasionally angioedema in response to cold stimulation. Antihistamines do not sufficiently protect all patients from symptoms, even when used in higher than standard doses. In these patients, desensitization to cold can be beneficial. The aim was to investigate whether desensitization can lower temperature thresholds and reduce release of histamine in the skin. Cold urticaria patients were subjected to desensitization and assessed for skin responses to cold stimulation and codeine before and after. Histamine levels mediated by cold and codeine were determined by cutaneous microdialysis before and after desensitization in patients and healthy controls. Desensitization to cold resulted in protection from cold-induced symptoms and lower temperature thresholds in six out of nine patients. Desensitization also prevented histamine release after skin exposure to cold. Surprisingly, skin histamine levels and release after codeine injection were found to be normal in desensitized patients.

AB - Cold urticaria is a skin condition characterized by rapid appearance of itchy wheals and occasionally angioedema in response to cold stimulation. Antihistamines do not sufficiently protect all patients from symptoms, even when used in higher than standard doses. In these patients, desensitization to cold can be beneficial. The aim was to investigate whether desensitization can lower temperature thresholds and reduce release of histamine in the skin. Cold urticaria patients were subjected to desensitization and assessed for skin responses to cold stimulation and codeine before and after. Histamine levels mediated by cold and codeine were determined by cutaneous microdialysis before and after desensitization in patients and healthy controls. Desensitization to cold resulted in protection from cold-induced symptoms and lower temperature thresholds in six out of nine patients. Desensitization also prevented histamine release after skin exposure to cold. Surprisingly, skin histamine levels and release after codeine injection were found to be normal in desensitized patients.

KW - Adolescent

KW - Adult

KW - Codeine

KW - Cold Temperature

KW - Desensitization, Immunologic

KW - Female

KW - Histamine Release

KW - Humans

KW - Immune Tolerance

KW - Male

KW - Mast Cells

KW - Middle Aged

KW - Treatment Outcome

KW - Urticaria

KW - Young Adult

U2 - 10.1159/000336572

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