TY - JOUR
T1 - Cohort profile
T2 - a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO)
AU - Specovius, Svenja
AU - Zimmermann, Hanna G.
AU - Oertel, Frederike Cosima
AU - Chien, Claudia
AU - Bereuter, Charlotte
AU - Cook, Lawrence J.
AU - Lana Peixoto, Marco Aurélio
AU - Fontenelle, Mariana Andrade
AU - Kim, Ho Jin
AU - Hyun, Jae Won
AU - Jung, Su Kyung
AU - Palace, Jacqueline
AU - Roca-Fernandez, Adriana
AU - Diaz, Alejandro Rubio
AU - Leite, Maria Isabel
AU - Sharma, Srilakshmi M.
AU - Ashtari, Fereshte
AU - Kafieh, Rahele
AU - Dehghani, Alireza
AU - Pourazizi, Mohsen
AU - Pandit, Lekha
AU - Dcunha, Anitha
AU - Aktas, Orhan
AU - Ringelstein, Marius
AU - Albrecht, Philipp
AU - May, Eugene
AU - Tongco, Caryl
AU - Leocani, Letizia
AU - Pisa, Marco
AU - Radaelli, Marta
AU - Martinez-Lapiscina, Elena H.
AU - Stiebel-Kalish, Hadas
AU - Hellmann, Mark
AU - Lotan, Itay
AU - Siritho, Sasitorn
AU - de Seze, Jérôme
AU - Senger, Thomas
AU - Havla, Joachim
AU - Marignier, Romain
AU - Tilikete, Caroline
AU - Cobo Calvo, Alvaro
AU - Bichuetti, Denis Bernardi
AU - Tavares, Ivan Maynart
AU - Asgari, Nasrin
AU - Soelberg, Kerstin
AU - Altintas, Ayse
AU - Yildirim, Rengin
AU - Tanriverdi, Uygur
AU - Jacob, Anu
AU - Huda, Saif
AU - Paul, Friedemann
AU - GJCF International Clinical Consortium for NMOSD
PY - 2020/10/29
Y1 - 2020/10/29
N2 - PURPOSE: Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. PARTICIPANTS: The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. FINDINGS TO DATE: The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. FUTURE PLANS: We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.
AB - PURPOSE: Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. PARTICIPANTS: The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. FINDINGS TO DATE: The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. FUTURE PLANS: We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.
KW - medical retina
KW - neuro-ophthalmology
KW - neurology
KW - radiology & imaging
U2 - 10.1136/bmjopen-2019-035397
DO - 10.1136/bmjopen-2019-035397
M3 - Journal article
C2 - 33122310
AN - SCOPUS:85094933587
SN - 2044-6055
VL - 10
JO - BMJ Open
JF - BMJ Open
IS - 10
M1 - e035397
ER -