Cognitive Dysfunction in Non-Alcoholic Fatty Liver Disease-Current Knowledge, Mechanisms and Perspectives.

Kristian Kjærgaard*, Anne Catrine Daugaard Mikkelsen, Charlotte Wilhelmina Wernberg, Lea Ladegaard Grønkjær, Peter Lykke Eriksen, MF Damholdt, Rajeshwar Prosad Mookerjee, Henrik Vilstrup, Mette Munk Lauridsen, Karen Louise Thomsen

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Abstrakt

Non-alcoholic fatty liver disease (NAFLD) has emerged as the hepatic component of the metabolic syndrome and now seemingly affects one-fourth of the world population. Features associated with NAFLD and the metabolic syndrome have frequently been linked to cognitive dysfunction, i.e. systemic inflammation, vascular dysfunction, and sleep apnoea. However, emerging evidence suggests that NAFLD may be a cause of cognitive dysfunction independent of these factors. NAFLD in addition exhibits dysbiosis of the gut microbiota and impaired urea cycle function, favouring systemic ammonia accumulation and further promotes systemic inflammation. Such disruption of the gut–liver–brain axis is essential in the pathogenesis of hepatic encephalopathy, the neuropsychiatric syndrome associated with progressive liver disease. Considering the growing burden of NAFLD, the morbidity from cognitive impairment is expected to have huge societal and economic impact. The present paper provides a review of the available evidence for cognitive dysfunction in NAFLD and outlines its possible mechanisms. Moreover, the clinical challenges of characterizing and diagnosing cognitive dysfunction in NAFLD are discussed.
OriginalsprogEngelsk
Artikelnummer673
TidsskriftJournal of Clinical Medicine
Vol/bind10
Udgave nummer4
Antal sider20
ISSN2077-0383
DOI
StatusUdgivet - feb. 2021

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