Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins

Merete Osler, Gunhild T Christensen, Ellen Garde, Erik L Mortensen, Kaare Christensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

INTRODUCTION: We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins.

METHODS: In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association between cognitive ability from draft board examination and dementia was examined using Cox regression.

RESULTS: During a 44-year follow-up, 6416 (0.96%) men developed dementia, 1760 (0.26%) and 970 (0.15%) of which were classified as Alzheimer's and vascular dementia, respectively. Low cognitive ability was associated with increased risk of dementia (hazard ratio [HR]per SD decrease 1.33 [95% confidence interval {CI} = 1.30-1.35]) with the strongest associations for vascular dementia (HRper SD decrease 1.47 [95% CI = 1.31-1.56]) and a weaker for Alzheimer's disease (HRper SD decrease 1.07 [95% CI = 1.03-1.13]). The intrabrother and twin analyses (taking shared family factors into account) showed attenuated risk estimates but with wide CIs.

DISCUSSION: Low early-life cognitive ability increases the risk of dementia before the age of 78 years. The association is partly explained by shared family factors.
OriginalsprogEngelsk
TidsskriftAlzheimer's & Dementia
Vol/bind13
Udgave nummer12
Sider (fra-til)1355-1363
ISSN1552-5260
DOI
StatusUdgivet - dec. 2017

Fingeraftryk

Siblings
Confidence Intervals
Alzheimer Disease
Registries

Emneord

  • Alzheimer's disease
  • Cognitive ability
  • Cohort study
  • Dementia
  • Twin study
  • Vascular dementia

Citer dette

Osler, Merete ; Christensen, Gunhild T ; Garde, Ellen ; Mortensen, Erik L ; Christensen, Kaare. / Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins. I: Alzheimer's & Dementia. 2017 ; Bind 13, Nr. 12. s. 1355-1363.
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title = "Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins",
abstract = "INTRODUCTION: We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins.METHODS: In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association between cognitive ability from draft board examination and dementia was examined using Cox regression.RESULTS: During a 44-year follow-up, 6416 (0.96{\%}) men developed dementia, 1760 (0.26{\%}) and 970 (0.15{\%}) of which were classified as Alzheimer's and vascular dementia, respectively. Low cognitive ability was associated with increased risk of dementia (hazard ratio [HR]per SD decrease 1.33 [95{\%} confidence interval {CI} = 1.30-1.35]) with the strongest associations for vascular dementia (HRper SD decrease 1.47 [95{\%} CI = 1.31-1.56]) and a weaker for Alzheimer's disease (HRper SD decrease 1.07 [95{\%} CI = 1.03-1.13]). The intrabrother and twin analyses (taking shared family factors into account) showed attenuated risk estimates but with wide CIs.DISCUSSION: Low early-life cognitive ability increases the risk of dementia before the age of 78 years. The association is partly explained by shared family factors.",
keywords = "Alzheimer's disease, Cognitive ability, Cohort study, Dementia, Twin study, Vascular dementia, Alzheimer's disease, Cognitive ability, Cohort study, Dementia, Twin study, Vascular dementia",
author = "Merete Osler and Christensen, {Gunhild T} and Ellen Garde and Mortensen, {Erik L} and Kaare Christensen",
note = "Copyright {\circledC} 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.",
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Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins. / Osler, Merete; Christensen, Gunhild T; Garde, Ellen; Mortensen, Erik L; Christensen, Kaare.

I: Alzheimer's & Dementia, Bind 13, Nr. 12, 12.2017, s. 1355-1363.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins

AU - Osler, Merete

AU - Christensen, Gunhild T

AU - Garde, Ellen

AU - Mortensen, Erik L

AU - Christensen, Kaare

N1 - Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

PY - 2017/12

Y1 - 2017/12

N2 - INTRODUCTION: We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins.METHODS: In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association between cognitive ability from draft board examination and dementia was examined using Cox regression.RESULTS: During a 44-year follow-up, 6416 (0.96%) men developed dementia, 1760 (0.26%) and 970 (0.15%) of which were classified as Alzheimer's and vascular dementia, respectively. Low cognitive ability was associated with increased risk of dementia (hazard ratio [HR]per SD decrease 1.33 [95% confidence interval {CI} = 1.30-1.35]) with the strongest associations for vascular dementia (HRper SD decrease 1.47 [95% CI = 1.31-1.56]) and a weaker for Alzheimer's disease (HRper SD decrease 1.07 [95% CI = 1.03-1.13]). The intrabrother and twin analyses (taking shared family factors into account) showed attenuated risk estimates but with wide CIs.DISCUSSION: Low early-life cognitive ability increases the risk of dementia before the age of 78 years. The association is partly explained by shared family factors.

AB - INTRODUCTION: We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins.METHODS: In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association between cognitive ability from draft board examination and dementia was examined using Cox regression.RESULTS: During a 44-year follow-up, 6416 (0.96%) men developed dementia, 1760 (0.26%) and 970 (0.15%) of which were classified as Alzheimer's and vascular dementia, respectively. Low cognitive ability was associated with increased risk of dementia (hazard ratio [HR]per SD decrease 1.33 [95% confidence interval {CI} = 1.30-1.35]) with the strongest associations for vascular dementia (HRper SD decrease 1.47 [95% CI = 1.31-1.56]) and a weaker for Alzheimer's disease (HRper SD decrease 1.07 [95% CI = 1.03-1.13]). The intrabrother and twin analyses (taking shared family factors into account) showed attenuated risk estimates but with wide CIs.DISCUSSION: Low early-life cognitive ability increases the risk of dementia before the age of 78 years. The association is partly explained by shared family factors.

KW - Alzheimer's disease

KW - Cognitive ability

KW - Cohort study

KW - Dementia

KW - Twin study

KW - Vascular dementia

KW - Alzheimer's disease

KW - Cognitive ability

KW - Cohort study

KW - Dementia

KW - Twin study

KW - Vascular dementia

U2 - 10.1016/j.jalz.2017.04.003

DO - 10.1016/j.jalz.2017.04.003

M3 - Journal article

C2 - 28531378

VL - 13

SP - 1355

EP - 1363

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 12

ER -