Clustering of autoimmune diseases in patients with rosacea

Alexander Egeberg, Peter Riis Hansen, Gunnar Hilmar Gislason, Jacob Pontoppidan Thyssen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    BACKGROUND: Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. A recent genomewide association study identified 90 genetic regions associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, respectively. However, a possible association with rosacea was not investigated.

    OBJECTIVE: We evaluated the association between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively.

    METHODS: We performed a population-based case-control study. A total of 6759 patients with rosacea were identified and matched with 33,795 control subjects on age, sex, and calendar time. We used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).

    RESULTS: After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95% CI 1.41-4.73), celiac disease (OR 2.03, 95% CI 1.35-3.07), multiple sclerosis (OR 1.65, 95% CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95% CI 1.82-2.52). The association was mainly observed in women.

    LIMITATIONS: We were unable to distinguish between the different subtypes and severities of rosacea.

    CONCLUSIONS: Rosacea is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively, in women, whereas the association in men only reached statistical significance for rheumatoid arthritis.

    OriginalsprogEngelsk
    TidsskriftAmerican Academy of Dermatology. Journal
    Vol/bind74
    Udgave nummer4
    Sider (fra-til)667-672.e1
    ISSN0190-9622
    DOI
    StatusUdgivet - apr. 2016

    Fingeraftryk

    Rosacea
    Cluster Analysis
    Celiac Disease
    Odds Ratio
    Confidence Intervals
    Case-Control Studies
    Logistic Models
    Smoking
    Skin

    Citer dette

    Egeberg, Alexander ; Hansen, Peter Riis ; Gislason, Gunnar Hilmar ; Thyssen, Jacob Pontoppidan. / Clustering of autoimmune diseases in patients with rosacea. I: American Academy of Dermatology. Journal. 2016 ; Bind 74, Nr. 4. s. 667-672.e1.
    @article{088fbeffd5df4a2e959bf96864b6eda6,
    title = "Clustering of autoimmune diseases in patients with rosacea",
    abstract = "BACKGROUND: Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. A recent genomewide association study identified 90 genetic regions associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, respectively. However, a possible association with rosacea was not investigated.OBJECTIVE: We evaluated the association between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively.METHODS: We performed a population-based case-control study. A total of 6759 patients with rosacea were identified and matched with 33,795 control subjects on age, sex, and calendar time. We used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95{\%} confidence intervals (CIs).RESULTS: After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95{\%} CI 1.41-4.73), celiac disease (OR 2.03, 95{\%} CI 1.35-3.07), multiple sclerosis (OR 1.65, 95{\%} CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95{\%} CI 1.82-2.52). The association was mainly observed in women.LIMITATIONS: We were unable to distinguish between the different subtypes and severities of rosacea.CONCLUSIONS: Rosacea is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively, in women, whereas the association in men only reached statistical significance for rheumatoid arthritis.",
    author = "Alexander Egeberg and Hansen, {Peter Riis} and Gislason, {Gunnar Hilmar} and Thyssen, {Jacob Pontoppidan}",
    note = "Copyright {\circledC} 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.",
    year = "2016",
    month = "4",
    doi = "10.1016/j.jaad.2015.11.004",
    language = "English",
    volume = "74",
    pages = "667--672.e1",
    journal = "American Academy of Dermatology. Journal",
    issn = "0190-9622",
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    Clustering of autoimmune diseases in patients with rosacea. / Egeberg, Alexander; Hansen, Peter Riis; Gislason, Gunnar Hilmar; Thyssen, Jacob Pontoppidan.

    I: American Academy of Dermatology. Journal, Bind 74, Nr. 4, 04.2016, s. 667-672.e1.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Clustering of autoimmune diseases in patients with rosacea

    AU - Egeberg, Alexander

    AU - Hansen, Peter Riis

    AU - Gislason, Gunnar Hilmar

    AU - Thyssen, Jacob Pontoppidan

    N1 - Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

    PY - 2016/4

    Y1 - 2016/4

    N2 - BACKGROUND: Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. A recent genomewide association study identified 90 genetic regions associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, respectively. However, a possible association with rosacea was not investigated.OBJECTIVE: We evaluated the association between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively.METHODS: We performed a population-based case-control study. A total of 6759 patients with rosacea were identified and matched with 33,795 control subjects on age, sex, and calendar time. We used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).RESULTS: After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95% CI 1.41-4.73), celiac disease (OR 2.03, 95% CI 1.35-3.07), multiple sclerosis (OR 1.65, 95% CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95% CI 1.82-2.52). The association was mainly observed in women.LIMITATIONS: We were unable to distinguish between the different subtypes and severities of rosacea.CONCLUSIONS: Rosacea is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively, in women, whereas the association in men only reached statistical significance for rheumatoid arthritis.

    AB - BACKGROUND: Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. A recent genomewide association study identified 90 genetic regions associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, respectively. However, a possible association with rosacea was not investigated.OBJECTIVE: We evaluated the association between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively.METHODS: We performed a population-based case-control study. A total of 6759 patients with rosacea were identified and matched with 33,795 control subjects on age, sex, and calendar time. We used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).RESULTS: After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95% CI 1.41-4.73), celiac disease (OR 2.03, 95% CI 1.35-3.07), multiple sclerosis (OR 1.65, 95% CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95% CI 1.82-2.52). The association was mainly observed in women.LIMITATIONS: We were unable to distinguish between the different subtypes and severities of rosacea.CONCLUSIONS: Rosacea is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively, in women, whereas the association in men only reached statistical significance for rheumatoid arthritis.

    U2 - 10.1016/j.jaad.2015.11.004

    DO - 10.1016/j.jaad.2015.11.004

    M3 - Journal article

    C2 - 26830864

    VL - 74

    SP - 667-672.e1

    JO - American Academy of Dermatology. Journal

    JF - American Academy of Dermatology. Journal

    SN - 0190-9622

    IS - 4

    ER -