Clinicopathological features of plasmablastic multiple myeloma: a population-based cohort

Hanne E H Møller, Birgitte S Preiss, Per Pedersen, Ida B Kristensen, Charlotte T Hansen, Mikael Frederiksen, Niels Abildgaard, Michael B Møller

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Multiple myeloma (MM) is a common malignant hematological disease displaying considerable heterogeneity. Historical data indicate a prognostic significance of plasmablastic morphology, proliferation, and adverse cytogenetics, but there is little knowledge on the degree of interdependency of these parameters. The aim of this study was to study the degree of overlap between these variables. In a consecutive population-based cohort of 194 untreated MM patients, morphology, and proliferation index, using immunohistochemical double staining for Ki-67 and CD138, was analyzed. In addition, cytogenetic changes were studied by karyotyping and fluorescence in situ hybridization (FISH). Plasmablastic morphology correlated with unfavorable clinical features, high proliferation index, high percentage of plasma cell infiltration in the bone marrow, abnormal karyotype, and del(13q) detected by karyotyping, which indicates that plasmablastic morphology reflects advanced and highly proliferative disease. However, plasmablastic morphology did not correlate with established adverse prognostic cytogenetics identified by FISH, for example, t(4;14), t(14;16) and del(17p).

OriginalsprogEngelsk
BogserieAPMIS Supplementum
Vol/bind123
Udgave nummer8
Sider (fra-til)652-658
Antal sider7
ISSN0903-465X
DOI
StatusUdgivet - aug. 2015

Emneord

  • Adult
  • Aged
  • Cell Proliferation
  • Cytogenetics
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Ki-67 Antigen
  • Male
  • Middle Aged
  • Multiple Myeloma
  • Plasma Cells
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Sequence Deletion
  • Syndecan-1

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