Clinical variables and magnetic resonance imaging-based radiomics predict human papillomavirus status of oropharyngeal cancer

Paula Bos*, Michiel W.M. van den Brekel, Zeno A.R. Gouw, Abrahim Al-Mamgani, Selam Waktola, Hugo J.W.L. Aerts, Regina G.H. Beets-Tan, Jonas A. Castelijns, Bas Jasperse

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have better prognosis and treatment response compared to HPV-negative OPSCC. This study aims to noninvasively predict HPV status of OPSCC using clinical and/or radiological variables. Methods: Seventy-seven magnetic resonance radiomic features were extracted from T1-weighted postcontrast images of the primary tumor of 153 patients. Logistic regression models were created to predict HPV status, determined with immunohistochemistry, based on clinical variables, radiomic features, and its combination. Model performance was evaluated using area under the curve (AUC). Results: Model performance showed AUCs of 0.794, 0.764, and 0.871 for the clinical, radiomic, and combined models, respectively. Smoking, higher T-classification (T3 and T4), larger, less round, and heterogeneous tumors were associated with HPV-negative tumors. Conclusion: Models based on clinical variables and/or radiomic tumor features can predict HPV status in OPSCC patients with good performance and can be considered when HPV testing is not available.

OriginalsprogEngelsk
TidsskriftHead and Neck
Vol/bind43
Udgave nummer2
Sider (fra-til)485-495
ISSN1043-3074
DOI
StatusUdgivet - feb. 2021

Fingeraftryk

Dyk ned i forskningsemnerne om 'Clinical variables and magnetic resonance imaging-based radiomics predict human papillomavirus status of oropharyngeal cancer'. Sammen danner de et unikt fingeraftryk.

Citationsformater