Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy

Lars Henrik Jensen, R Altaf, H Harling, M Jensen, S Laurberg, J C Lindegaard, A Muhic, L Vestermark, Anders Jakobsen, S Bülow

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2010-Mar
OriginalsprogEngelsk
TidsskriftEuropean Journal of Surgical Oncology
Vol/bind36
Udgave nummer3
Sider (fra-til)237-43
Antal sider6
ISSN0748-7983
DOI
StatusUdgivet - 1. mar. 2010

Fingeraftryk

Rectal Neoplasms
Neoplasms
Rectum
Disease-Free Survival
Survival Rate
Clinical Trials
Databases
Population

Citer dette

@article{b4c56410850511df846a000ea68e967b,
title = "Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy",
abstract = "AIM: The purpose of this study was to analyse the results of preoperative short course radiotherapy in a consecutive, national cohort of patients with rectal cancer. METHODS: Through a validated, prospective national database we identified 520 Danish patients who presented with high-risk mobile tumours in the lower two thirds of the rectum and were referred for preoperative radiotherapy with 5 x 5 Gy. The inclusion period was 56 months. Radiotherapy data was retrospectively collected. RESULTS: Of the 520 patients, 514 completed radiotherapy and 506 had surgery. Surgery was considered curative in 439 patients. The 3-year local recurrence rate was 4.0{\%} (95{\%} CI 2.5-6.5{\%}) and the distant recurrence rate at 3 years was 18.7{\%} (95{\%} CI 15.4-22.5{\%}). The 5-year disease free survival rate was 40.2{\%} (95{\%} CI 27.0-53.1{\%}) and overall survival 50.4{\%} (95{\%} CI 36.1-63.1{\%}). Most tumours (61{\%}) were classified as T3 or T4 and 41{\%} of the local recurrences occurred in patients with a fixed tumour at surgery. CONCLUSION: This study confirms data from randomised studies that the short course 5 x 5 Gy regime is a feasible treatment for locally advanced rectal cancer even when applied in a population outside clinical trials.",
keywords = "Adult, Aged, Aged, 80 and over, Colectomy, Denmark, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Neoplasm Recurrence, Local, Preoperative Care, Prospective Studies, Rectal Neoplasms, Survival Rate, Time Factors, Treatment Outcome",
author = "Jensen, {Lars Henrik} and R Altaf and H Harling and M Jensen and S Laurberg and Lindegaard, {J C} and A Muhic and L Vestermark and Anders Jakobsen and S B{\"u}low",
note = "Copyright (c) 2009 Elsevier Ltd. All rights reserved.",
year = "2010",
month = "3",
day = "1",
doi = "10.1016/j.ejso.2009.10.008",
language = "English",
volume = "36",
pages = "237--43",
journal = "European Journal of Surgical Oncology",
issn = "0748-7983",
publisher = "Heinemann",
number = "3",

}

Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy. / Jensen, Lars Henrik; Altaf, R; Harling, H; Jensen, M; Laurberg, S; Lindegaard, J C; Muhic, A; Vestermark, L; Jakobsen, Anders; Bülow, S.

I: European Journal of Surgical Oncology, Bind 36, Nr. 3, 01.03.2010, s. 237-43.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy

AU - Jensen, Lars Henrik

AU - Altaf, R

AU - Harling, H

AU - Jensen, M

AU - Laurberg, S

AU - Lindegaard, J C

AU - Muhic, A

AU - Vestermark, L

AU - Jakobsen, Anders

AU - Bülow, S

N1 - Copyright (c) 2009 Elsevier Ltd. All rights reserved.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - AIM: The purpose of this study was to analyse the results of preoperative short course radiotherapy in a consecutive, national cohort of patients with rectal cancer. METHODS: Through a validated, prospective national database we identified 520 Danish patients who presented with high-risk mobile tumours in the lower two thirds of the rectum and were referred for preoperative radiotherapy with 5 x 5 Gy. The inclusion period was 56 months. Radiotherapy data was retrospectively collected. RESULTS: Of the 520 patients, 514 completed radiotherapy and 506 had surgery. Surgery was considered curative in 439 patients. The 3-year local recurrence rate was 4.0% (95% CI 2.5-6.5%) and the distant recurrence rate at 3 years was 18.7% (95% CI 15.4-22.5%). The 5-year disease free survival rate was 40.2% (95% CI 27.0-53.1%) and overall survival 50.4% (95% CI 36.1-63.1%). Most tumours (61%) were classified as T3 or T4 and 41% of the local recurrences occurred in patients with a fixed tumour at surgery. CONCLUSION: This study confirms data from randomised studies that the short course 5 x 5 Gy regime is a feasible treatment for locally advanced rectal cancer even when applied in a population outside clinical trials.

AB - AIM: The purpose of this study was to analyse the results of preoperative short course radiotherapy in a consecutive, national cohort of patients with rectal cancer. METHODS: Through a validated, prospective national database we identified 520 Danish patients who presented with high-risk mobile tumours in the lower two thirds of the rectum and were referred for preoperative radiotherapy with 5 x 5 Gy. The inclusion period was 56 months. Radiotherapy data was retrospectively collected. RESULTS: Of the 520 patients, 514 completed radiotherapy and 506 had surgery. Surgery was considered curative in 439 patients. The 3-year local recurrence rate was 4.0% (95% CI 2.5-6.5%) and the distant recurrence rate at 3 years was 18.7% (95% CI 15.4-22.5%). The 5-year disease free survival rate was 40.2% (95% CI 27.0-53.1%) and overall survival 50.4% (95% CI 36.1-63.1%). Most tumours (61%) were classified as T3 or T4 and 41% of the local recurrences occurred in patients with a fixed tumour at surgery. CONCLUSION: This study confirms data from randomised studies that the short course 5 x 5 Gy regime is a feasible treatment for locally advanced rectal cancer even when applied in a population outside clinical trials.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Colectomy

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Preoperative Care

KW - Prospective Studies

KW - Rectal Neoplasms

KW - Survival Rate

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1016/j.ejso.2009.10.008

DO - 10.1016/j.ejso.2009.10.008

M3 - Journal article

VL - 36

SP - 237

EP - 243

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

SN - 0748-7983

IS - 3

ER -