Clinical appearance of erythema migrans caused by Borrelia afzelii and Borrelia garinii--effect of the patient's sex

Louise Bennet, Carl-Johan Fraenkel, Ulf Garpmo, Anders Halling, Mikael Ingman, Katharina Ornstein, Louise Stjernberg, Johan Berglund

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2006-Sep
OriginalsprogEngelsk
TidsskriftWiener Klinische Wochenschrift
Vol/bind118
Udgave nummer17-18
Sider (fra-til)531-7
Antal sider6
ISSN0043-5325
DOI
StatusUdgivet - 1. sep. 2006
Udgivet eksterntJa

Fingeraftryk

Erythema
Polymerase Chain Reaction
Logistic Models
Ambulatory Care Facilities
Exanthema
Odds Ratio
Prospective Studies
Serum

Citer dette

Bennet, L., Fraenkel, C-J., Garpmo, U., Halling, A., Ingman, M., Ornstein, K., ... Berglund, J. (2006). Clinical appearance of erythema migrans caused by Borrelia afzelii and Borrelia garinii--effect of the patient's sex. Wiener Klinische Wochenschrift, 118(17-18), 531-7. https://doi.org/10.1007/s00508-006-0659-1
Bennet, Louise ; Fraenkel, Carl-Johan ; Garpmo, Ulf ; Halling, Anders ; Ingman, Mikael ; Ornstein, Katharina ; Stjernberg, Louise ; Berglund, Johan. / Clinical appearance of erythema migrans caused by Borrelia afzelii and Borrelia garinii--effect of the patient's sex. I: Wiener Klinische Wochenschrift. 2006 ; Bind 118, Nr. 17-18. s. 531-7.
@article{db0dfe2051fc11df937d000ea68e967b,
title = "Clinical appearance of erythema migrans caused by Borrelia afzelii and Borrelia garinii--effect of the patient's sex",
abstract = "AIM: The aim in this survey was to study the clinical characteristics of infections caused by Borrelia genospecies in patients with erythema migrans where borrelial origin was confirmed by polymerase chain reaction. The aim was also to study factors influencing the clinical appearance of erythema migrans. METHODS: The study was conducted in southern Sweden from May 2001 to December 2003 on patients 18 years and older attending with erythema migrans at outpatient clinics. All erythema migrans were verified by polymerase chain reaction, photographed and categorized as {"}annular{"} or {"}non-annular{"} lesions. A logistic regression model was used to analyze relations between the appearance of the erythema migrans (i.e. annular or non-annular) and factors that influenced its clinical appearance. RESULTS: A total of 118 patients, 54 women (45.8{\%}) and 64 men (54.2{\%}), fulfilled the inclusion criteria. Of these patients, 74{\%} were infected by B. afzelii and 26{\%} by B. garinii (p < 0.001). A total of 45{\%} (38/85) of the erythema migrans were annular, 46{\%} (39/85) were nonannular and 9.4{\%} (8/85) were atypical. For men infected by B. afzelii, the odds ratio of developing non-annular erythema migrans was 0.09 (95{\%} CI: 0.03-0.33) in comparison with women with the same infection. CONCLUSIONS: In this prospective study of a large series of erythema migrans, where infecting genospecies were confirmed by polymerase chain reaction, the sex of patients infected with B. afzelii had a strong influence on the appearance of the rash. Patients infected by B. garinii more often had non-annular erythema migrans and a more virulent infection with more individuals presenting with fever, raised levels of C-reactive protein and seroreactivity in the convalescence sera.",
author = "Louise Bennet and Carl-Johan Fraenkel and Ulf Garpmo and Anders Halling and Mikael Ingman and Katharina Ornstein and Louise Stjernberg and Johan Berglund",
year = "2006",
month = "9",
day = "1",
doi = "10.1007/s00508-006-0659-1",
language = "English",
volume = "118",
pages = "531--7",
journal = "Wiener Klinische Wochenschrift",
issn = "0043-5325",
publisher = "Springer",
number = "17-18",

}

Bennet, L, Fraenkel, C-J, Garpmo, U, Halling, A, Ingman, M, Ornstein, K, Stjernberg, L & Berglund, J 2006, 'Clinical appearance of erythema migrans caused by Borrelia afzelii and Borrelia garinii--effect of the patient's sex', Wiener Klinische Wochenschrift, bind 118, nr. 17-18, s. 531-7. https://doi.org/10.1007/s00508-006-0659-1

Clinical appearance of erythema migrans caused by Borrelia afzelii and Borrelia garinii--effect of the patient's sex. / Bennet, Louise; Fraenkel, Carl-Johan; Garpmo, Ulf; Halling, Anders; Ingman, Mikael; Ornstein, Katharina; Stjernberg, Louise; Berglund, Johan.

I: Wiener Klinische Wochenschrift, Bind 118, Nr. 17-18, 01.09.2006, s. 531-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Clinical appearance of erythema migrans caused by Borrelia afzelii and Borrelia garinii--effect of the patient's sex

AU - Bennet, Louise

AU - Fraenkel, Carl-Johan

AU - Garpmo, Ulf

AU - Halling, Anders

AU - Ingman, Mikael

AU - Ornstein, Katharina

AU - Stjernberg, Louise

AU - Berglund, Johan

PY - 2006/9/1

Y1 - 2006/9/1

N2 - AIM: The aim in this survey was to study the clinical characteristics of infections caused by Borrelia genospecies in patients with erythema migrans where borrelial origin was confirmed by polymerase chain reaction. The aim was also to study factors influencing the clinical appearance of erythema migrans. METHODS: The study was conducted in southern Sweden from May 2001 to December 2003 on patients 18 years and older attending with erythema migrans at outpatient clinics. All erythema migrans were verified by polymerase chain reaction, photographed and categorized as "annular" or "non-annular" lesions. A logistic regression model was used to analyze relations between the appearance of the erythema migrans (i.e. annular or non-annular) and factors that influenced its clinical appearance. RESULTS: A total of 118 patients, 54 women (45.8%) and 64 men (54.2%), fulfilled the inclusion criteria. Of these patients, 74% were infected by B. afzelii and 26% by B. garinii (p < 0.001). A total of 45% (38/85) of the erythema migrans were annular, 46% (39/85) were nonannular and 9.4% (8/85) were atypical. For men infected by B. afzelii, the odds ratio of developing non-annular erythema migrans was 0.09 (95% CI: 0.03-0.33) in comparison with women with the same infection. CONCLUSIONS: In this prospective study of a large series of erythema migrans, where infecting genospecies were confirmed by polymerase chain reaction, the sex of patients infected with B. afzelii had a strong influence on the appearance of the rash. Patients infected by B. garinii more often had non-annular erythema migrans and a more virulent infection with more individuals presenting with fever, raised levels of C-reactive protein and seroreactivity in the convalescence sera.

AB - AIM: The aim in this survey was to study the clinical characteristics of infections caused by Borrelia genospecies in patients with erythema migrans where borrelial origin was confirmed by polymerase chain reaction. The aim was also to study factors influencing the clinical appearance of erythema migrans. METHODS: The study was conducted in southern Sweden from May 2001 to December 2003 on patients 18 years and older attending with erythema migrans at outpatient clinics. All erythema migrans were verified by polymerase chain reaction, photographed and categorized as "annular" or "non-annular" lesions. A logistic regression model was used to analyze relations between the appearance of the erythema migrans (i.e. annular or non-annular) and factors that influenced its clinical appearance. RESULTS: A total of 118 patients, 54 women (45.8%) and 64 men (54.2%), fulfilled the inclusion criteria. Of these patients, 74% were infected by B. afzelii and 26% by B. garinii (p < 0.001). A total of 45% (38/85) of the erythema migrans were annular, 46% (39/85) were nonannular and 9.4% (8/85) were atypical. For men infected by B. afzelii, the odds ratio of developing non-annular erythema migrans was 0.09 (95% CI: 0.03-0.33) in comparison with women with the same infection. CONCLUSIONS: In this prospective study of a large series of erythema migrans, where infecting genospecies were confirmed by polymerase chain reaction, the sex of patients infected with B. afzelii had a strong influence on the appearance of the rash. Patients infected by B. garinii more often had non-annular erythema migrans and a more virulent infection with more individuals presenting with fever, raised levels of C-reactive protein and seroreactivity in the convalescence sera.

U2 - 10.1007/s00508-006-0659-1

DO - 10.1007/s00508-006-0659-1

M3 - Journal article

VL - 118

SP - 531

EP - 537

JO - Wiener Klinische Wochenschrift

JF - Wiener Klinische Wochenschrift

SN - 0043-5325

IS - 17-18

ER -