Cleaning and coating procedures determine biological properties of gyroid porous titanium implants

Fatma Nur Depboylu; Beliz Taşkonak; Petek Korkusuz; Evren Yasa; Olatunji Ajiteru; Kyu Young Choi; Chan Hum Park; Özgür Poyraz; Andrei Alexandru Popa; Feza Korkusuz

doi:10.1007/s42247-024-00774-2

Cleaning and coating procedures determine biological properties of gyroid porous titanium implants

Fatma Nur Depboylu, Beliz Taşkonak, Petek Korkusuz, Evren Yasa, Olatunji Ajiteru, Kyu Young Choi, Chan Hum Park, Özgür Poyraz, Andrei Alexandru Popa, Feza Korkusuz^*

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Cleaning and coating processes as well as biocompatibility of gyroid commercially pure titanium (Cp-Ti) biomedical implants using the laser powder bed fusion (L-PBF) technology were analyzed. Etching time for cleaning of gyroid Cp-Ti biomedical implants were determined to remove non-melted particles from the surface. Nano hydroxyapatite (nHA) and polylactic acid (PLA) composite coating on the gyroid Cp-Ti implants via dip coating were optimized. Dip coating’s withdrawal speed also, the amount of nHA:PLA and viscosity effects of composite were evaluated. 1000 mm/min withdrawal speed prevented clogging of the pores. In addition, silk fibroin was coated on gyroid Cp-Ti implants with electro deposition method. Optimum coating thicknesses were achieved. Biocompatibility after PLA:nHA and silk fibroin were studied. Gyroid and solid Cp-Ti presented 3% and 1% mass loss after a minute of HF/HNO₃ etching. The three-minute etching protocol led to the highest micro pit width formation on the surfaces. 70:30 PLA:nHA and silk fibroin established crack-free coatings on gyroid Cp-Ti surfaces. MTT, live-dead cell assay revealed good biocompatibility after coating.

Originalsprog	Engelsk
Tidsskrift	Emergent Materials
ISSN	2522-5731
DOI	https://doi.org/10.1007/s42247-024-00774-2
Status	E-pub ahead of print - 5. jul. 2024

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Publisher Copyright:
© The Author(s) 2024.

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10.1007/s42247-024-00774-2Licens: CC BY

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title = "Cleaning and coating procedures determine biological properties of gyroid porous titanium implants",

abstract = "Cleaning and coating processes as well as biocompatibility of gyroid commercially pure titanium (Cp-Ti) biomedical implants using the laser powder bed fusion (L-PBF) technology were analyzed. Etching time for cleaning of gyroid Cp-Ti biomedical implants were determined to remove non-melted particles from the surface. Nano hydroxyapatite (nHA) and polylactic acid (PLA) composite coating on the gyroid Cp-Ti implants via dip coating were optimized. Dip coating{\textquoteright}s withdrawal speed also, the amount of nHA:PLA and viscosity effects of composite were evaluated. 1000 mm/min withdrawal speed prevented clogging of the pores. In addition, silk fibroin was coated on gyroid Cp-Ti implants with electro deposition method. Optimum coating thicknesses were achieved. Biocompatibility after PLA:nHA and silk fibroin were studied. Gyroid and solid Cp-Ti presented 3% and 1% mass loss after a minute of HF/HNO3 etching. The three-minute etching protocol led to the highest micro pit width formation on the surfaces. 70:30 PLA:nHA and silk fibroin established crack-free coatings on gyroid Cp-Ti surfaces. MTT, live-dead cell assay revealed good biocompatibility after coating.",

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author = "Depboylu, {Fatma Nur} and Beliz Ta{\c s}konak and Petek Korkusuz and Evren Yasa and Olatunji Ajiteru and Choi, {Kyu Young} and Park, {Chan Hum} and {\"O}zg{\"u}r Poyraz and Popa, {Andrei Alexandru} and Feza Korkusuz",

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T1 - Cleaning and coating procedures determine biological properties of gyroid porous titanium implants

AU - Depboylu, Fatma Nur

AU - Taşkonak, Beliz

AU - Korkusuz, Petek

AU - Yasa, Evren

AU - Ajiteru, Olatunji

AU - Choi, Kyu Young

AU - Park, Chan Hum

AU - Poyraz, Özgür

AU - Popa, Andrei Alexandru

AU - Korkusuz, Feza

PY - 2024/7/5

Y1 - 2024/7/5

N2 - Cleaning and coating processes as well as biocompatibility of gyroid commercially pure titanium (Cp-Ti) biomedical implants using the laser powder bed fusion (L-PBF) technology were analyzed. Etching time for cleaning of gyroid Cp-Ti biomedical implants were determined to remove non-melted particles from the surface. Nano hydroxyapatite (nHA) and polylactic acid (PLA) composite coating on the gyroid Cp-Ti implants via dip coating were optimized. Dip coating’s withdrawal speed also, the amount of nHA:PLA and viscosity effects of composite were evaluated. 1000 mm/min withdrawal speed prevented clogging of the pores. In addition, silk fibroin was coated on gyroid Cp-Ti implants with electro deposition method. Optimum coating thicknesses were achieved. Biocompatibility after PLA:nHA and silk fibroin were studied. Gyroid and solid Cp-Ti presented 3% and 1% mass loss after a minute of HF/HNO3 etching. The three-minute etching protocol led to the highest micro pit width formation on the surfaces. 70:30 PLA:nHA and silk fibroin established crack-free coatings on gyroid Cp-Ti surfaces. MTT, live-dead cell assay revealed good biocompatibility after coating.

AB - Cleaning and coating processes as well as biocompatibility of gyroid commercially pure titanium (Cp-Ti) biomedical implants using the laser powder bed fusion (L-PBF) technology were analyzed. Etching time for cleaning of gyroid Cp-Ti biomedical implants were determined to remove non-melted particles from the surface. Nano hydroxyapatite (nHA) and polylactic acid (PLA) composite coating on the gyroid Cp-Ti implants via dip coating were optimized. Dip coating’s withdrawal speed also, the amount of nHA:PLA and viscosity effects of composite were evaluated. 1000 mm/min withdrawal speed prevented clogging of the pores. In addition, silk fibroin was coated on gyroid Cp-Ti implants with electro deposition method. Optimum coating thicknesses were achieved. Biocompatibility after PLA:nHA and silk fibroin were studied. Gyroid and solid Cp-Ti presented 3% and 1% mass loss after a minute of HF/HNO3 etching. The three-minute etching protocol led to the highest micro pit width formation on the surfaces. 70:30 PLA:nHA and silk fibroin established crack-free coatings on gyroid Cp-Ti surfaces. MTT, live-dead cell assay revealed good biocompatibility after coating.

KW - Cell viability

KW - Chemical etching

KW - Composite

KW - Dip coating

KW - Electro-deposition technique

KW - Silk-fibroin

U2 - 10.1007/s42247-024-00774-2

DO - 10.1007/s42247-024-00774-2

M3 - Journal article

AN - SCOPUS:85197555527

SN - 2522-5731

JO - Emergent Materials

JF - Emergent Materials

ER -

Cleaning and coating procedures determine biological properties of gyroid porous titanium implants

Abstract

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