Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006

Henrik W Kiaer, Anne-Vibeke Laenkholm, Bernt B Nielsen, Karsten D Bjerre

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2008
OriginalsprogEngelsk
TidsskriftActa Oncologica
Vol/bind47
Udgave nummer4
Sider (fra-til)778-783
Antal sider5
ISSN0284-186X
DOI
StatusUdgivet - 1. jan. 2008

Fingeraftryk

Lymph Nodes
Large-Core Needle Biopsy
Neoplasms

Citer dette

Kiaer, Henrik W ; Laenkholm, Anne-Vibeke ; Nielsen, Bernt B ; Bjerre, Karsten D. / Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006. I: Acta Oncologica. 2008 ; Bind 47, Nr. 4. s. 778-783.
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title = "Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006",
abstract = "The Danish Breast Cancer Cooperative Group's register containing data from about 75 000 patients undergoing surgery for primary invasive breast cancer from 1978-2006 has been examined for classical pathological variables. During that period the diagnostic approach of malignant breast tumours experienced a major shift from invasive surgical procedures to non invasive procedures with an increase of the proportion of both fine needle aspiration biopsy and core needle biopsy. According to variation in tumour size there has been a slight increase in tumours <10 mm and a significant decrease in tumours >50mm from 7 to 4{\%}. The distribution of the histological subtypes of malignant breast tumours has been almost unchanged. We found however a significant increase in the number of high grade tumours. A large increase in the number of removed axillary lymph nodes from 1989-2001 is related to improved surgical procedure. The subsequent decline from 2002-2006 is the result of the introduction of the sentinel node technique. In the five-year period 2002-2006 following the introduction of sentinel node technique, the frequency of patients having at least one lymph node metastases (48.7{\%}) was higher than in the preceding five-year period 1997-2001 (44.4{\%}, p=0.0087).",
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Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006. / Kiaer, Henrik W; Laenkholm, Anne-Vibeke; Nielsen, Bernt B; Bjerre, Karsten D.

I: Acta Oncologica, Bind 47, Nr. 4, 01.01.2008, s. 778-783.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006

AU - Kiaer, Henrik W

AU - Laenkholm, Anne-Vibeke

AU - Nielsen, Bernt B

AU - Bjerre, Karsten D

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The Danish Breast Cancer Cooperative Group's register containing data from about 75 000 patients undergoing surgery for primary invasive breast cancer from 1978-2006 has been examined for classical pathological variables. During that period the diagnostic approach of malignant breast tumours experienced a major shift from invasive surgical procedures to non invasive procedures with an increase of the proportion of both fine needle aspiration biopsy and core needle biopsy. According to variation in tumour size there has been a slight increase in tumours <10 mm and a significant decrease in tumours >50mm from 7 to 4%. The distribution of the histological subtypes of malignant breast tumours has been almost unchanged. We found however a significant increase in the number of high grade tumours. A large increase in the number of removed axillary lymph nodes from 1989-2001 is related to improved surgical procedure. The subsequent decline from 2002-2006 is the result of the introduction of the sentinel node technique. In the five-year period 2002-2006 following the introduction of sentinel node technique, the frequency of patients having at least one lymph node metastases (48.7%) was higher than in the preceding five-year period 1997-2001 (44.4%, p=0.0087).

AB - The Danish Breast Cancer Cooperative Group's register containing data from about 75 000 patients undergoing surgery for primary invasive breast cancer from 1978-2006 has been examined for classical pathological variables. During that period the diagnostic approach of malignant breast tumours experienced a major shift from invasive surgical procedures to non invasive procedures with an increase of the proportion of both fine needle aspiration biopsy and core needle biopsy. According to variation in tumour size there has been a slight increase in tumours <10 mm and a significant decrease in tumours >50mm from 7 to 4%. The distribution of the histological subtypes of malignant breast tumours has been almost unchanged. We found however a significant increase in the number of high grade tumours. A large increase in the number of removed axillary lymph nodes from 1989-2001 is related to improved surgical procedure. The subsequent decline from 2002-2006 is the result of the introduction of the sentinel node technique. In the five-year period 2002-2006 following the introduction of sentinel node technique, the frequency of patients having at least one lymph node metastases (48.7%) was higher than in the preceding five-year period 1997-2001 (44.4%, p=0.0087).

KW - Breast Neoplasms

KW - Denmark

KW - Female

KW - Humans

KW - Incidence

KW - Lymphatic Metastasis

KW - Neoplasm Staging

KW - Registries

U2 - 10.1080/02841860802039889

DO - 10.1080/02841860802039889

M3 - Journal article

VL - 47

SP - 778

EP - 783

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 4

ER -