Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus

A. Troldborg, S. Thiel, L. Jensen, M. J. Laska, Søren Werner Karlskov Hansen, B. Deleuran, J. C. Jensenius, K. Stengaard-Pedersen

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Resumé

Background/Purpose: The complement system is one of the key players in the pathogenesis of systemic lupus erythematosus (SLE). Collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1) are recently discovered complement pattern recognition molecules. They form hetero-complexes termed CL-LK that collaborate with associated serine proteases to activate the lectin pathway of complement. The objective of this pilot study was to explore the involvement of CL-LK in a cross-sectional cohort of SLE patients by measuring plasma concentrations and analyze for associations between the plasma concentrations and characteristic SLE manifestations. Methods: Prospectively, blood samples (citrated plasma), ACR classification criteria and SLE disease activity index score (SLEDAI) were collected from 58 SLE patients. Concentrations in plasma of CL-L1 and CL-K1 were determined in the SLE patients and in age and gender matched healthy controls using time resolved immuno-flourometric assays developed in house. Results: Both the CL-L1 and CL-K1 concentrations were lower in SLE patients than healthy controls (p
OriginalsprogEngelsk
Artikelnummer198
TidsskriftArthritis & Rheumatology
Vol/bind67
Udgave nummerS10
Antal sider2
ISSN2326-5191
DOI
StatusUdgivet - 2015
BegivenhedACR/ARHP: American College of Rheumatology - San Francisco, USA
Varighed: 7. nov. 201511. nov. 2015

Konference

KonferenceACR/ARHP
LandUSA
BySan Francisco
Periode07/11/201511/11/2015

Emneord

  • *pattern recognition *systemic lupus erythematosus *American *college *rheumatology *health practitioner *human patient blood level plasma pathogenesis classification blood sampling liver pilot study hypocomplementemia disease activity score assay hypothesis gender SLEDAI kidney complement system collectin lectin complement component C3 serine proteinase

Citer dette

Troldborg, A., Thiel, S., Jensen, L., Laska, M. J., Hansen, S. W. K., Deleuran, B., ... Stengaard-Pedersen, K. (2015). Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus. Arthritis & Rheumatology, 67(S10), [198]. https://doi.org/10.1002/art.39448
Troldborg, A. ; Thiel, S. ; Jensen, L. ; Laska, M. J. ; Hansen, Søren Werner Karlskov ; Deleuran, B. ; Jensenius, J. C. ; Stengaard-Pedersen, K. / Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus. I: Arthritis & Rheumatology. 2015 ; Bind 67, Nr. S10.
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title = "Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus",
abstract = "Background/Purpose: The complement system is one of the key players in the pathogenesis of systemic lupus erythematosus (SLE). Collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1) are recently discovered complement pattern recognition molecules. They form hetero-complexes termed CL-LK that collaborate with associated serine proteases to activate the lectin pathway of complement. The objective of this pilot study was to explore the involvement of CL-LK in a cross-sectional cohort of SLE patients by measuring plasma concentrations and analyze for associations between the plasma concentrations and characteristic SLE manifestations. Methods: Prospectively, blood samples (citrated plasma), ACR classification criteria and SLE disease activity index score (SLEDAI) were collected from 58 SLE patients. Concentrations in plasma of CL-L1 and CL-K1 were determined in the SLE patients and in age and gender matched healthy controls using time resolved immuno-flourometric assays developed in house. Results: Both the CL-L1 and CL-K1 concentrations were lower in SLE patients than healthy controls (p",
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author = "A. Troldborg and S. Thiel and L. Jensen and Laska, {M. J.} and Hansen, {S{\o}ren Werner Karlskov} and B. Deleuran and Jensenius, {J. C.} and K. Stengaard-Pedersen",
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Troldborg, A, Thiel, S, Jensen, L, Laska, MJ, Hansen, SWK, Deleuran, B, Jensenius, JC & Stengaard-Pedersen, K 2015, 'Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus', Arthritis & Rheumatology, bind 67, nr. S10, 198. https://doi.org/10.1002/art.39448

Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus. / Troldborg, A.; Thiel, S.; Jensen, L.; Laska, M. J.; Hansen, Søren Werner Karlskov; Deleuran, B.; Jensenius, J. C.; Stengaard-Pedersen, K.

I: Arthritis & Rheumatology, Bind 67, Nr. S10, 198, 2015.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

TY - ABST

T1 - Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus

AU - Troldborg, A.

AU - Thiel, S.

AU - Jensen, L.

AU - Laska, M. J.

AU - Hansen, Søren Werner Karlskov

AU - Deleuran, B.

AU - Jensenius, J. C.

AU - Stengaard-Pedersen, K.

PY - 2015

Y1 - 2015

N2 - Background/Purpose: The complement system is one of the key players in the pathogenesis of systemic lupus erythematosus (SLE). Collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1) are recently discovered complement pattern recognition molecules. They form hetero-complexes termed CL-LK that collaborate with associated serine proteases to activate the lectin pathway of complement. The objective of this pilot study was to explore the involvement of CL-LK in a cross-sectional cohort of SLE patients by measuring plasma concentrations and analyze for associations between the plasma concentrations and characteristic SLE manifestations. Methods: Prospectively, blood samples (citrated plasma), ACR classification criteria and SLE disease activity index score (SLEDAI) were collected from 58 SLE patients. Concentrations in plasma of CL-L1 and CL-K1 were determined in the SLE patients and in age and gender matched healthy controls using time resolved immuno-flourometric assays developed in house. Results: Both the CL-L1 and CL-K1 concentrations were lower in SLE patients than healthy controls (p

AB - Background/Purpose: The complement system is one of the key players in the pathogenesis of systemic lupus erythematosus (SLE). Collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1) are recently discovered complement pattern recognition molecules. They form hetero-complexes termed CL-LK that collaborate with associated serine proteases to activate the lectin pathway of complement. The objective of this pilot study was to explore the involvement of CL-LK in a cross-sectional cohort of SLE patients by measuring plasma concentrations and analyze for associations between the plasma concentrations and characteristic SLE manifestations. Methods: Prospectively, blood samples (citrated plasma), ACR classification criteria and SLE disease activity index score (SLEDAI) were collected from 58 SLE patients. Concentrations in plasma of CL-L1 and CL-K1 were determined in the SLE patients and in age and gender matched healthy controls using time resolved immuno-flourometric assays developed in house. Results: Both the CL-L1 and CL-K1 concentrations were lower in SLE patients than healthy controls (p

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DO - 10.1002/art.39448

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VL - 67

JO - Arthritis & Rheumatology

JF - Arthritis & Rheumatology

SN - 2326-5191

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M1 - 198

ER -