Circadian profile of QT interval and QT interval variability in 172 healthy volunteers

Hendrik Bonnemeier, Uwe K H Wiegand, Wiebke Braasch, Axel Brandes, Gert Richardt, Jürgen Potratz

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The limited prognostic value of QT dispersion has been demonstrated in recent studies. However, longitudinal data on physiological variations of QT interval and the influence of aging and sex are few. This analysis included 172 healthy subjects (89 women, 83 men; mean age 38.7 +/- 15 years). Beat-to-beat QT interval duration (QT, QTapex [QTa], Tend [Te]), variability (QTSD, QTaSD), and the mean R-R interval were determined from 24-hour ambulatory electrocardiograms after exclusion of artifacts and premature beats. All volunteers were fully active, awoke at approximately 7:00 AM, and had 6-8 hours of sleep. QT and R-R intervals revealed a characteristic day-night-pattern. Diurnal profiles of QT interval variability exhibited a significant increase in the morning hours (6-9 AM; P < 0.01) and a consecutive decline to baseline levels. In female subjects the R-R and Tend intervals were significantly lower at day- and nighttime. Aging was associated with an increase of QT interval mainly at daytime and a significant shift of the T wave apex towards the end of the T wave. The circadian profile of ventricular repolarization is strongly related to the mean R-R interval, however, there are significant alterations mainly at daytime with normal aging. Furthermore, the diurnal course of the QT interval variability strongly suggests that it is related to cardiac sympathetic activity and to the reported diurnal pattern of malignant ventricular arrhythmias.

OriginalsprogEngelsk
TidsskriftPacing and Clinical Electrophysiology
Vol/bind26
Udgave nummer1 Pt 2
Sider (fra-til)377-82
Antal sider6
ISSN0147-8389
StatusUdgivet - jan. 2003

Fingeraftryk

Artifacts
Volunteers
Electrocardiography

Citer dette

Bonnemeier, H., Wiegand, U. K. H., Braasch, W., Brandes, A., Richardt, G., & Potratz, J. (2003). Circadian profile of QT interval and QT interval variability in 172 healthy volunteers. Pacing and Clinical Electrophysiology, 26(1 Pt 2), 377-82.
Bonnemeier, Hendrik ; Wiegand, Uwe K H ; Braasch, Wiebke ; Brandes, Axel ; Richardt, Gert ; Potratz, Jürgen. / Circadian profile of QT interval and QT interval variability in 172 healthy volunteers. I: Pacing and Clinical Electrophysiology. 2003 ; Bind 26, Nr. 1 Pt 2. s. 377-82.
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Bonnemeier, H, Wiegand, UKH, Braasch, W, Brandes, A, Richardt, G & Potratz, J 2003, 'Circadian profile of QT interval and QT interval variability in 172 healthy volunteers', Pacing and Clinical Electrophysiology, bind 26, nr. 1 Pt 2, s. 377-82.

Circadian profile of QT interval and QT interval variability in 172 healthy volunteers. / Bonnemeier, Hendrik; Wiegand, Uwe K H; Braasch, Wiebke; Brandes, Axel; Richardt, Gert; Potratz, Jürgen.

I: Pacing and Clinical Electrophysiology, Bind 26, Nr. 1 Pt 2, 01.2003, s. 377-82.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Circadian profile of QT interval and QT interval variability in 172 healthy volunteers

AU - Bonnemeier, Hendrik

AU - Wiegand, Uwe K H

AU - Braasch, Wiebke

AU - Brandes, Axel

AU - Richardt, Gert

AU - Potratz, Jürgen

PY - 2003/1

Y1 - 2003/1

N2 - The limited prognostic value of QT dispersion has been demonstrated in recent studies. However, longitudinal data on physiological variations of QT interval and the influence of aging and sex are few. This analysis included 172 healthy subjects (89 women, 83 men; mean age 38.7 +/- 15 years). Beat-to-beat QT interval duration (QT, QTapex [QTa], Tend [Te]), variability (QTSD, QTaSD), and the mean R-R interval were determined from 24-hour ambulatory electrocardiograms after exclusion of artifacts and premature beats. All volunteers were fully active, awoke at approximately 7:00 AM, and had 6-8 hours of sleep. QT and R-R intervals revealed a characteristic day-night-pattern. Diurnal profiles of QT interval variability exhibited a significant increase in the morning hours (6-9 AM; P < 0.01) and a consecutive decline to baseline levels. In female subjects the R-R and Tend intervals were significantly lower at day- and nighttime. Aging was associated with an increase of QT interval mainly at daytime and a significant shift of the T wave apex towards the end of the T wave. The circadian profile of ventricular repolarization is strongly related to the mean R-R interval, however, there are significant alterations mainly at daytime with normal aging. Furthermore, the diurnal course of the QT interval variability strongly suggests that it is related to cardiac sympathetic activity and to the reported diurnal pattern of malignant ventricular arrhythmias.

AB - The limited prognostic value of QT dispersion has been demonstrated in recent studies. However, longitudinal data on physiological variations of QT interval and the influence of aging and sex are few. This analysis included 172 healthy subjects (89 women, 83 men; mean age 38.7 +/- 15 years). Beat-to-beat QT interval duration (QT, QTapex [QTa], Tend [Te]), variability (QTSD, QTaSD), and the mean R-R interval were determined from 24-hour ambulatory electrocardiograms after exclusion of artifacts and premature beats. All volunteers were fully active, awoke at approximately 7:00 AM, and had 6-8 hours of sleep. QT and R-R intervals revealed a characteristic day-night-pattern. Diurnal profiles of QT interval variability exhibited a significant increase in the morning hours (6-9 AM; P < 0.01) and a consecutive decline to baseline levels. In female subjects the R-R and Tend intervals were significantly lower at day- and nighttime. Aging was associated with an increase of QT interval mainly at daytime and a significant shift of the T wave apex towards the end of the T wave. The circadian profile of ventricular repolarization is strongly related to the mean R-R interval, however, there are significant alterations mainly at daytime with normal aging. Furthermore, the diurnal course of the QT interval variability strongly suggests that it is related to cardiac sympathetic activity and to the reported diurnal pattern of malignant ventricular arrhythmias.

KW - Adult

KW - Aged

KW - Aging

KW - Circadian Rhythm

KW - Electrocardiography

KW - Electrocardiography, Ambulatory

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Reference Values

KW - Sex Characteristics

M3 - Journal article

C2 - 12687849

VL - 26

SP - 377

EP - 382

JO - Pacing and Clinical Electrophysiology

JF - Pacing and Clinical Electrophysiology

SN - 0147-8389

IS - 1 Pt 2

ER -

Bonnemeier H, Wiegand UKH, Braasch W, Brandes A, Richardt G, Potratz J. Circadian profile of QT interval and QT interval variability in 172 healthy volunteers. Pacing and Clinical Electrophysiology. 2003 jan;26(1 Pt 2):377-82.