Chronic use of lithium is safe with regard to the development of kidney and urinary tract cancers

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Resumé

Background: Lithium induces proliferation in the epithelium of renal collecting ducts. A recent small-scale cohort study reported a strong association between use of lithium and increased risk of renal neoplasia. Objectives: The aim of this study was to study the association between long-term use of lithium and risk of upper urinary tract cancer (UUTC), including renal cell cancer and cancers of renal pelvis or ureter. Methods: Using the powerful Danish nationwide registries and a case-control approach, we identified all histologically verified UUTC cases in Denmark between 2000 and 2012 from the Danish Cancer Registry. A total of 6477 cases were matched on age and gender to 259 080 cancer-free controls. Data on lithium use were obtained from 1995 to 2012 from the Danish Prescription Registry. We estimated the association between long-term use of lithium (>5 years) and risk of UUTC using conditional logistic regression with adjustment for potential confounders. Results: Long-term use of lithium was observed among 0.22% of cases and 0.17% of controls. This yielded an overall adjusted odds ratio (OR) of 1.3 (95%CI: 0.8-2.2) for UUTC associated with long-term use of lithium. Analyses stratified by stage and subtype of cancer displayed a slightly increased risk of localized UUTC (OR 1.6, 95%CI: 0.8-3.0) and renal pelvis/ureter cancers (OR 1.7, 95%CI: 0.5-5.5). Conclusions: In our nationwide case-control study, use of lithium was not associated with an increased risk of UUTC.
OriginalsprogEngelsk
Artikelnummer54
TidsskriftPharmacoepidemiology and Drug Safety
Vol/bind24
Udgave nummerS1
Sider (fra-til)32
Antal sider1
ISSN1053-8569
StatusUdgivet - 2015
Begivenhed31st International Conference on Pharmacoepidemiology and Therapeutic Risk Management - Boston, USA
Varighed: 22. aug. 201526. aug. 2015

Konference

Konference31st International Conference on Pharmacoepidemiology and Therapeutic Risk Management
LandUSA
ByBoston
Periode22/08/201526/08/2015

Fingeraftryk

Urologic Neoplasms
Lithium
Kidney
Ureteral Neoplasms
Pelvic Neoplasms
Registries
Kidney Pelvis
Odds Ratio
Neoplasms
Kidney Neoplasms
Denmark
Prescriptions
Case-Control Studies
Cohort Studies
Epithelium
Logistic Models

Emneord

  • *kidney *urinary tract cancer *pharmacoepidemiology *risk management neoplasm risk register logistic regression analysis prescription cancer registry cohort analysis ureter kidney pelvis Denmark gender kidney cell human case control study urinary tract epithelium *lithium

Citer dette

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title = "Chronic use of lithium is safe with regard to the development of kidney and urinary tract cancers",
abstract = "Background: Lithium induces proliferation in the epithelium of renal collecting ducts. A recent small-scale cohort study reported a strong association between use of lithium and increased risk of renal neoplasia. Objectives: The aim of this study was to study the association between long-term use of lithium and risk of upper urinary tract cancer (UUTC), including renal cell cancer and cancers of renal pelvis or ureter. Methods: Using the powerful Danish nationwide registries and a case-control approach, we identified all histologically verified UUTC cases in Denmark between 2000 and 2012 from the Danish Cancer Registry. A total of 6477 cases were matched on age and gender to 259 080 cancer-free controls. Data on lithium use were obtained from 1995 to 2012 from the Danish Prescription Registry. We estimated the association between long-term use of lithium (>5 years) and risk of UUTC using conditional logistic regression with adjustment for potential confounders. Results: Long-term use of lithium was observed among 0.22{\%} of cases and 0.17{\%} of controls. This yielded an overall adjusted odds ratio (OR) of 1.3 (95{\%}CI: 0.8-2.2) for UUTC associated with long-term use of lithium. Analyses stratified by stage and subtype of cancer displayed a slightly increased risk of localized UUTC (OR 1.6, 95{\%}CI: 0.8-3.0) and renal pelvis/ureter cancers (OR 1.7, 95{\%}CI: 0.5-5.5). Conclusions: In our nationwide case-control study, use of lithium was not associated with an increased risk of UUTC.",
keywords = "*kidney *urinary tract cancer *pharmacoepidemiology *risk management neoplasm risk register logistic regression analysis prescription cancer registry cohort analysis ureter kidney pelvis Denmark gender kidney cell human case control study urinary tract epithelium *lithium",
author = "Anton Potteg{\aa}rd and Jesper Hallas and Jensen, {Boye L.} and Kirsten Madsen and S{\o}ren Friid",
year = "2015",
language = "English",
volume = "24",
pages = "32",
journal = "Pharmacoepidemiology and Drug Safety",
issn = "1053-8569",
publisher = "JohnWiley & Sons Ltd.",
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}

Chronic use of lithium is safe with regard to the development of kidney and urinary tract cancers. / Pottegård, Anton; Hallas, Jesper; Jensen, Boye L.; Madsen, Kirsten; Friid, Søren.

I: Pharmacoepidemiology and Drug Safety, Bind 24, Nr. S1, 54, 2015, s. 32.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

TY - ABST

T1 - Chronic use of lithium is safe with regard to the development of kidney and urinary tract cancers

AU - Pottegård, Anton

AU - Hallas, Jesper

AU - Jensen, Boye L.

AU - Madsen, Kirsten

AU - Friid, Søren

PY - 2015

Y1 - 2015

N2 - Background: Lithium induces proliferation in the epithelium of renal collecting ducts. A recent small-scale cohort study reported a strong association between use of lithium and increased risk of renal neoplasia. Objectives: The aim of this study was to study the association between long-term use of lithium and risk of upper urinary tract cancer (UUTC), including renal cell cancer and cancers of renal pelvis or ureter. Methods: Using the powerful Danish nationwide registries and a case-control approach, we identified all histologically verified UUTC cases in Denmark between 2000 and 2012 from the Danish Cancer Registry. A total of 6477 cases were matched on age and gender to 259 080 cancer-free controls. Data on lithium use were obtained from 1995 to 2012 from the Danish Prescription Registry. We estimated the association between long-term use of lithium (>5 years) and risk of UUTC using conditional logistic regression with adjustment for potential confounders. Results: Long-term use of lithium was observed among 0.22% of cases and 0.17% of controls. This yielded an overall adjusted odds ratio (OR) of 1.3 (95%CI: 0.8-2.2) for UUTC associated with long-term use of lithium. Analyses stratified by stage and subtype of cancer displayed a slightly increased risk of localized UUTC (OR 1.6, 95%CI: 0.8-3.0) and renal pelvis/ureter cancers (OR 1.7, 95%CI: 0.5-5.5). Conclusions: In our nationwide case-control study, use of lithium was not associated with an increased risk of UUTC.

AB - Background: Lithium induces proliferation in the epithelium of renal collecting ducts. A recent small-scale cohort study reported a strong association between use of lithium and increased risk of renal neoplasia. Objectives: The aim of this study was to study the association between long-term use of lithium and risk of upper urinary tract cancer (UUTC), including renal cell cancer and cancers of renal pelvis or ureter. Methods: Using the powerful Danish nationwide registries and a case-control approach, we identified all histologically verified UUTC cases in Denmark between 2000 and 2012 from the Danish Cancer Registry. A total of 6477 cases were matched on age and gender to 259 080 cancer-free controls. Data on lithium use were obtained from 1995 to 2012 from the Danish Prescription Registry. We estimated the association between long-term use of lithium (>5 years) and risk of UUTC using conditional logistic regression with adjustment for potential confounders. Results: Long-term use of lithium was observed among 0.22% of cases and 0.17% of controls. This yielded an overall adjusted odds ratio (OR) of 1.3 (95%CI: 0.8-2.2) for UUTC associated with long-term use of lithium. Analyses stratified by stage and subtype of cancer displayed a slightly increased risk of localized UUTC (OR 1.6, 95%CI: 0.8-3.0) and renal pelvis/ureter cancers (OR 1.7, 95%CI: 0.5-5.5). Conclusions: In our nationwide case-control study, use of lithium was not associated with an increased risk of UUTC.

KW - kidney urinary tract cancer pharmacoepidemiology risk management neoplasm risk register logistic regression analysis prescription cancer registry cohort analysis ureter kidney pelvis Denmark gender kidney cell human case control study urinary tract epithe

M3 - Conference abstract in journal

VL - 24

SP - 32

JO - Pharmacoepidemiology and Drug Safety

JF - Pharmacoepidemiology and Drug Safety

SN - 1053-8569

IS - S1

M1 - 54

ER -