Chronic treatment with epidermal growth factor induces growth of the rat ventral prostate

N Tørring, L V Jensen, J G Wen, Flemming Brandt Sørensen, J C Djurhuus, E Nexø

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE: The epidermal growth factor (EGF) system is expressed in the rat prostate, and growth factors from this system induce proliferation in prostate epithelial and stromal cell cultures. The aim of the study was to investigate the possible growth-promoting effects of the system during the hyperplastic growth phase of the prostate in newborn rats.

MATERIAL AND METHODS: Newborn rats were treated for 8 weeks with EGF (150 microg/kg body weight per day), administered as daily subcutaneous injections. Sections of the prostate tissue were examined by a stereological technique to determine tissue composition.

RESULTS: Treatment with EGF increased the weight of the ventral prostate, relative to body weight, by 50% compared with placebo (p < 0.005). Neither the dorsolateral prostate, seminal vesicles nor coagulating glands were affected by EGF. Prostate tissue showed a significant increase in the volume of the prostate epithelium, the stroma and the lumen following EGF treatment, in a pattern resembling physiological growth of the ventral prostate. A significant correlation (r = 0.78, p < 0.0001) of the volume fraction of the lumen with the glandular weight of the ventral prostate was seen. Serum testosterone was not affected by chronic EGF administration.

CONCLUSIONS: EGF selectively induces growth of the ventral lobe of the prostate in newborn rats, in a pattern comparable to normal physiological growth. It may be hypothesized that the physiological growth of the prostate is directly correlated to endogenous activity of the EGF system in the rat prostate gland.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Urology and Nephrology
Vol/bind35
Udgave nummer5
Sider (fra-til)339-44
Antal sider6
ISSN0036-5599
StatusUdgivet - okt. 2001

Fingeraftryk

Epidermal Growth Factor
Prostate
Growth
Weights and Measures
Seminal Vesicles
Stromal Cells
Epithelium
Epithelial Cells
Placebos

Citer dette

Tørring, N., Jensen, L. V., Wen, J. G., Sørensen, F. B., Djurhuus, J. C., & Nexø, E. (2001). Chronic treatment with epidermal growth factor induces growth of the rat ventral prostate. Scandinavian Journal of Urology and Nephrology, 35(5), 339-44.
Tørring, N ; Jensen, L V ; Wen, J G ; Sørensen, Flemming Brandt ; Djurhuus, J C ; Nexø, E. / Chronic treatment with epidermal growth factor induces growth of the rat ventral prostate. I: Scandinavian Journal of Urology and Nephrology. 2001 ; Bind 35, Nr. 5. s. 339-44.
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abstract = "OBJECTIVE: The epidermal growth factor (EGF) system is expressed in the rat prostate, and growth factors from this system induce proliferation in prostate epithelial and stromal cell cultures. The aim of the study was to investigate the possible growth-promoting effects of the system during the hyperplastic growth phase of the prostate in newborn rats.MATERIAL AND METHODS: Newborn rats were treated for 8 weeks with EGF (150 microg/kg body weight per day), administered as daily subcutaneous injections. Sections of the prostate tissue were examined by a stereological technique to determine tissue composition.RESULTS: Treatment with EGF increased the weight of the ventral prostate, relative to body weight, by 50{\%} compared with placebo (p < 0.005). Neither the dorsolateral prostate, seminal vesicles nor coagulating glands were affected by EGF. Prostate tissue showed a significant increase in the volume of the prostate epithelium, the stroma and the lumen following EGF treatment, in a pattern resembling physiological growth of the ventral prostate. A significant correlation (r = 0.78, p < 0.0001) of the volume fraction of the lumen with the glandular weight of the ventral prostate was seen. Serum testosterone was not affected by chronic EGF administration.CONCLUSIONS: EGF selectively induces growth of the ventral lobe of the prostate in newborn rats, in a pattern comparable to normal physiological growth. It may be hypothesized that the physiological growth of the prostate is directly correlated to endogenous activity of the EGF system in the rat prostate gland.",
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Tørring, N, Jensen, LV, Wen, JG, Sørensen, FB, Djurhuus, JC & Nexø, E 2001, 'Chronic treatment with epidermal growth factor induces growth of the rat ventral prostate', Scandinavian Journal of Urology and Nephrology, bind 35, nr. 5, s. 339-44.

Chronic treatment with epidermal growth factor induces growth of the rat ventral prostate. / Tørring, N; Jensen, L V; Wen, J G; Sørensen, Flemming Brandt; Djurhuus, J C; Nexø, E.

I: Scandinavian Journal of Urology and Nephrology, Bind 35, Nr. 5, 10.2001, s. 339-44.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Chronic treatment with epidermal growth factor induces growth of the rat ventral prostate

AU - Tørring, N

AU - Jensen, L V

AU - Wen, J G

AU - Sørensen, Flemming Brandt

AU - Djurhuus, J C

AU - Nexø, E

PY - 2001/10

Y1 - 2001/10

N2 - OBJECTIVE: The epidermal growth factor (EGF) system is expressed in the rat prostate, and growth factors from this system induce proliferation in prostate epithelial and stromal cell cultures. The aim of the study was to investigate the possible growth-promoting effects of the system during the hyperplastic growth phase of the prostate in newborn rats.MATERIAL AND METHODS: Newborn rats were treated for 8 weeks with EGF (150 microg/kg body weight per day), administered as daily subcutaneous injections. Sections of the prostate tissue were examined by a stereological technique to determine tissue composition.RESULTS: Treatment with EGF increased the weight of the ventral prostate, relative to body weight, by 50% compared with placebo (p < 0.005). Neither the dorsolateral prostate, seminal vesicles nor coagulating glands were affected by EGF. Prostate tissue showed a significant increase in the volume of the prostate epithelium, the stroma and the lumen following EGF treatment, in a pattern resembling physiological growth of the ventral prostate. A significant correlation (r = 0.78, p < 0.0001) of the volume fraction of the lumen with the glandular weight of the ventral prostate was seen. Serum testosterone was not affected by chronic EGF administration.CONCLUSIONS: EGF selectively induces growth of the ventral lobe of the prostate in newborn rats, in a pattern comparable to normal physiological growth. It may be hypothesized that the physiological growth of the prostate is directly correlated to endogenous activity of the EGF system in the rat prostate gland.

AB - OBJECTIVE: The epidermal growth factor (EGF) system is expressed in the rat prostate, and growth factors from this system induce proliferation in prostate epithelial and stromal cell cultures. The aim of the study was to investigate the possible growth-promoting effects of the system during the hyperplastic growth phase of the prostate in newborn rats.MATERIAL AND METHODS: Newborn rats were treated for 8 weeks with EGF (150 microg/kg body weight per day), administered as daily subcutaneous injections. Sections of the prostate tissue were examined by a stereological technique to determine tissue composition.RESULTS: Treatment with EGF increased the weight of the ventral prostate, relative to body weight, by 50% compared with placebo (p < 0.005). Neither the dorsolateral prostate, seminal vesicles nor coagulating glands were affected by EGF. Prostate tissue showed a significant increase in the volume of the prostate epithelium, the stroma and the lumen following EGF treatment, in a pattern resembling physiological growth of the ventral prostate. A significant correlation (r = 0.78, p < 0.0001) of the volume fraction of the lumen with the glandular weight of the ventral prostate was seen. Serum testosterone was not affected by chronic EGF administration.CONCLUSIONS: EGF selectively induces growth of the ventral lobe of the prostate in newborn rats, in a pattern comparable to normal physiological growth. It may be hypothesized that the physiological growth of the prostate is directly correlated to endogenous activity of the EGF system in the rat prostate gland.

KW - Animals

KW - Animals, Newborn

KW - Cell Division

KW - Epidermal Growth Factor

KW - Injections, Subcutaneous

KW - Male

KW - Organ Size

KW - Prostate

KW - Rats

KW - Rats, Wistar

KW - Time Factors

M3 - Journal article

C2 - 11771858

VL - 35

SP - 339

EP - 344

JO - Scandinavian Journal of Urology and Nephrology

JF - Scandinavian Journal of Urology and Nephrology

SN - 0036-5599

IS - 5

ER -

Tørring N, Jensen LV, Wen JG, Sørensen FB, Djurhuus JC, Nexø E. Chronic treatment with epidermal growth factor induces growth of the rat ventral prostate. Scandinavian Journal of Urology and Nephrology. 2001 okt;35(5):339-44.