Choroidal thickness and myopia in relation to physical activity during childhood

Kristian Lundberg, Nina Jacobsen, Anders Højslet Vestergaard, Ernst Goldschmidt, Tunde Peto, Mikael Larsen, Niels Wedderkopp, Jakob Grauslund

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

52 Downloads (Pure)

Resumé

Purpose: Decreasing physical activity (PA) has been suggested to be a driving force behind the rapid increase of myopia worldwide. The possible protective effects of PA might be through increased blood flow and subsequent change in thickness of the choroid. The purpose of this study was to correlate PA, myopia, and choroidal thickness (CT). Methods: A prospective study of 307 children from the CHAMPS-study Denmark. Objective data from a GT3X accelerometer (ActiGraph, USA) worn at 4 periods between 2009 and 2015 were used to determine the amount and intensity of PA. Intensity was estimated as counts/minutes, and cut off-points were defined at four intensity levels; sedentary (SED), light (L), moderate (M) and vigorous (V). Eye examinations were performed in 2015 and included autorefraction in cyclopegia (Tonoref II, Nidek, Japan), axial length (AL) by biometri (Lenstar 900, Haag Streit, Switzerland) and fovea-centered radial scans of 4 sections by enhanced depth imaging optical coherence tomography (EDI-OCT) (Heidelberg Spectralis, Germany). By a validated semi-automated method we measured the CT at 17 targets per eye representing anatomically different choroidal locations (subfoveal, 1 and 3 millimeter in each direction of fovea). Linear regression and slope coefficients of repeated PA were performed to evaluate the association between PA, myopia and CT. Results: Mean age at follow-up was 15.4±0.7 years (range 14.3 to 17.5) and 52.4% were boys. The mean spherical equivalent (SE) was 0.3±1.5 diopters (cycloplegia) and 17.9% were myopic (SE≤-0.5 diopters). The mean AL was 23.5±0.9 mm. The mean subfoveal CT was 369±87 µm. The mean CT for myopic vs. non-myopic eyes was 259±65 µm vs. 354±71 µm (macula), 313±77 µm vs. 382±84 µm (fovea), 306±71 µm vs. 368±80 µm (1 mm zone) and 267±52 µm vs. 312±59 µm (3 mm zone), respectively. All CT measurements were thinner in myopic eyes (p<0.0001) and in boys (p<0.05). By age- and sex-adjusted linear regression there were no associations between PA and SE, AL or any CT measurements. There was no association between accumulated PA and the overall CT for SED, L, M and V PA (2.31 µm/% (p=0.22), -3.99 µm/% (p=0.15), -5.43 µm/% (p=0.57) and -0.53 µm/% (p=0.95), respectively). Conclusions: We found no association between physical activity and the choroidal thickness, axial length or refractive error. However, the choroid was thinner in myopic eyes and in boys. The role of choroidal thickness on the development of refraction should be investigated in prospective studies.
OriginalsprogEngelsk
Publikationsdato8. maj 2017
Antal sider1
StatusUdgivet - 8. maj 2017
BegivenhedAssociation for Research in Vision and Ophthalmology Annual Meeting 2017 - Baltimore, USA
Varighed: 7. maj 201711. maj 2017

Konference

KonferenceAssociation for Research in Vision and Ophthalmology Annual Meeting 2017
LandUSA
ByBaltimore
Periode07/05/201711/05/2017

Emneord

  • Myopia
  • Choroid
  • Physical activity
  • Children

Citer dette

Lundberg, K., Jacobsen, N., Vestergaard, A. H., Goldschmidt, E., Peto, T., Larsen, M., ... Grauslund, J. (2017). Choroidal thickness and myopia in relation to physical activity during childhood. Poster session præsenteret på Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, USA.
Lundberg, Kristian ; Jacobsen, Nina ; Vestergaard, Anders Højslet ; Goldschmidt, Ernst ; Peto, Tunde ; Larsen, Mikael ; Wedderkopp, Niels ; Grauslund, Jakob. / Choroidal thickness and myopia in relation to physical activity during childhood. Poster session præsenteret på Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, USA.1 s.
@conference{412df160d748468ea313ccc292a789dc,
title = "Choroidal thickness and myopia in relation to physical activity during childhood",
abstract = "Purpose: Decreasing physical activity (PA) has been suggested to be a driving force behind the rapid increase of myopia worldwide. The possible protective effects of PA might be through increased blood flow and subsequent change in thickness of the choroid. The purpose of this study was to correlate PA, myopia, and choroidal thickness (CT). Methods: A prospective study of 307 children from the CHAMPS-study Denmark. Objective data from a GT3X accelerometer (ActiGraph, USA) worn at 4 periods between 2009 and 2015 were used to determine the amount and intensity of PA. Intensity was estimated as counts/minutes, and cut off-points were defined at four intensity levels; sedentary (SED), light (L), moderate (M) and vigorous (V). Eye examinations were performed in 2015 and included autorefraction in cyclopegia (Tonoref II, Nidek, Japan), axial length (AL) by biometri (Lenstar 900, Haag Streit, Switzerland) and fovea-centered radial scans of 4 sections by enhanced depth imaging optical coherence tomography (EDI-OCT) (Heidelberg Spectralis, Germany). By a validated semi-automated method we measured the CT at 17 targets per eye representing anatomically different choroidal locations (subfoveal, 1 and 3 millimeter in each direction of fovea). Linear regression and slope coefficients of repeated PA were performed to evaluate the association between PA, myopia and CT. Results: Mean age at follow-up was 15.4±0.7 years (range 14.3 to 17.5) and 52.4{\%} were boys. The mean spherical equivalent (SE) was 0.3±1.5 diopters (cycloplegia) and 17.9{\%} were myopic (SE≤-0.5 diopters). The mean AL was 23.5±0.9 mm. The mean subfoveal CT was 369±87 µm. The mean CT for myopic vs. non-myopic eyes was 259±65 µm vs. 354±71 µm (macula), 313±77 µm vs. 382±84 µm (fovea), 306±71 µm vs. 368±80 µm (1 mm zone) and 267±52 µm vs. 312±59 µm (3 mm zone), respectively. All CT measurements were thinner in myopic eyes (p<0.0001) and in boys (p<0.05). By age- and sex-adjusted linear regression there were no associations between PA and SE, AL or any CT measurements. There was no association between accumulated PA and the overall CT for SED, L, M and V PA (2.31 µm/{\%} (p=0.22), -3.99 µm/{\%} (p=0.15), -5.43 µm/{\%} (p=0.57) and -0.53 µm/{\%} (p=0.95), respectively). Conclusions: We found no association between physical activity and the choroidal thickness, axial length or refractive error. However, the choroid was thinner in myopic eyes and in boys. The role of choroidal thickness on the development of refraction should be investigated in prospective studies.",
keywords = "Myopia , Choroid, Physical activity, Children",
author = "Kristian Lundberg and Nina Jacobsen and Vestergaard, {Anders H{\o}jslet} and Ernst Goldschmidt and Tunde Peto and Mikael Larsen and Niels Wedderkopp and Jakob Grauslund",
year = "2017",
month = "5",
day = "8",
language = "English",
note = "null ; Conference date: 07-05-2017 Through 11-05-2017",

}

Lundberg, K, Jacobsen, N, Vestergaard, AH, Goldschmidt, E, Peto, T, Larsen, M, Wedderkopp, N & Grauslund, J 2017, 'Choroidal thickness and myopia in relation to physical activity during childhood', Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, USA, 07/05/2017 - 11/05/2017.

Choroidal thickness and myopia in relation to physical activity during childhood. / Lundberg, Kristian ; Jacobsen, Nina; Vestergaard, Anders Højslet; Goldschmidt, Ernst; Peto, Tunde ; Larsen, Mikael; Wedderkopp, Niels; Grauslund, Jakob.

2017. Poster session præsenteret på Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, USA.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

TY - CONF

T1 - Choroidal thickness and myopia in relation to physical activity during childhood

AU - Lundberg, Kristian

AU - Jacobsen, Nina

AU - Vestergaard, Anders Højslet

AU - Goldschmidt, Ernst

AU - Peto, Tunde

AU - Larsen, Mikael

AU - Wedderkopp, Niels

AU - Grauslund, Jakob

PY - 2017/5/8

Y1 - 2017/5/8

N2 - Purpose: Decreasing physical activity (PA) has been suggested to be a driving force behind the rapid increase of myopia worldwide. The possible protective effects of PA might be through increased blood flow and subsequent change in thickness of the choroid. The purpose of this study was to correlate PA, myopia, and choroidal thickness (CT). Methods: A prospective study of 307 children from the CHAMPS-study Denmark. Objective data from a GT3X accelerometer (ActiGraph, USA) worn at 4 periods between 2009 and 2015 were used to determine the amount and intensity of PA. Intensity was estimated as counts/minutes, and cut off-points were defined at four intensity levels; sedentary (SED), light (L), moderate (M) and vigorous (V). Eye examinations were performed in 2015 and included autorefraction in cyclopegia (Tonoref II, Nidek, Japan), axial length (AL) by biometri (Lenstar 900, Haag Streit, Switzerland) and fovea-centered radial scans of 4 sections by enhanced depth imaging optical coherence tomography (EDI-OCT) (Heidelberg Spectralis, Germany). By a validated semi-automated method we measured the CT at 17 targets per eye representing anatomically different choroidal locations (subfoveal, 1 and 3 millimeter in each direction of fovea). Linear regression and slope coefficients of repeated PA were performed to evaluate the association between PA, myopia and CT. Results: Mean age at follow-up was 15.4±0.7 years (range 14.3 to 17.5) and 52.4% were boys. The mean spherical equivalent (SE) was 0.3±1.5 diopters (cycloplegia) and 17.9% were myopic (SE≤-0.5 diopters). The mean AL was 23.5±0.9 mm. The mean subfoveal CT was 369±87 µm. The mean CT for myopic vs. non-myopic eyes was 259±65 µm vs. 354±71 µm (macula), 313±77 µm vs. 382±84 µm (fovea), 306±71 µm vs. 368±80 µm (1 mm zone) and 267±52 µm vs. 312±59 µm (3 mm zone), respectively. All CT measurements were thinner in myopic eyes (p<0.0001) and in boys (p<0.05). By age- and sex-adjusted linear regression there were no associations between PA and SE, AL or any CT measurements. There was no association between accumulated PA and the overall CT for SED, L, M and V PA (2.31 µm/% (p=0.22), -3.99 µm/% (p=0.15), -5.43 µm/% (p=0.57) and -0.53 µm/% (p=0.95), respectively). Conclusions: We found no association between physical activity and the choroidal thickness, axial length or refractive error. However, the choroid was thinner in myopic eyes and in boys. The role of choroidal thickness on the development of refraction should be investigated in prospective studies.

AB - Purpose: Decreasing physical activity (PA) has been suggested to be a driving force behind the rapid increase of myopia worldwide. The possible protective effects of PA might be through increased blood flow and subsequent change in thickness of the choroid. The purpose of this study was to correlate PA, myopia, and choroidal thickness (CT). Methods: A prospective study of 307 children from the CHAMPS-study Denmark. Objective data from a GT3X accelerometer (ActiGraph, USA) worn at 4 periods between 2009 and 2015 were used to determine the amount and intensity of PA. Intensity was estimated as counts/minutes, and cut off-points were defined at four intensity levels; sedentary (SED), light (L), moderate (M) and vigorous (V). Eye examinations were performed in 2015 and included autorefraction in cyclopegia (Tonoref II, Nidek, Japan), axial length (AL) by biometri (Lenstar 900, Haag Streit, Switzerland) and fovea-centered radial scans of 4 sections by enhanced depth imaging optical coherence tomography (EDI-OCT) (Heidelberg Spectralis, Germany). By a validated semi-automated method we measured the CT at 17 targets per eye representing anatomically different choroidal locations (subfoveal, 1 and 3 millimeter in each direction of fovea). Linear regression and slope coefficients of repeated PA were performed to evaluate the association between PA, myopia and CT. Results: Mean age at follow-up was 15.4±0.7 years (range 14.3 to 17.5) and 52.4% were boys. The mean spherical equivalent (SE) was 0.3±1.5 diopters (cycloplegia) and 17.9% were myopic (SE≤-0.5 diopters). The mean AL was 23.5±0.9 mm. The mean subfoveal CT was 369±87 µm. The mean CT for myopic vs. non-myopic eyes was 259±65 µm vs. 354±71 µm (macula), 313±77 µm vs. 382±84 µm (fovea), 306±71 µm vs. 368±80 µm (1 mm zone) and 267±52 µm vs. 312±59 µm (3 mm zone), respectively. All CT measurements were thinner in myopic eyes (p<0.0001) and in boys (p<0.05). By age- and sex-adjusted linear regression there were no associations between PA and SE, AL or any CT measurements. There was no association between accumulated PA and the overall CT for SED, L, M and V PA (2.31 µm/% (p=0.22), -3.99 µm/% (p=0.15), -5.43 µm/% (p=0.57) and -0.53 µm/% (p=0.95), respectively). Conclusions: We found no association between physical activity and the choroidal thickness, axial length or refractive error. However, the choroid was thinner in myopic eyes and in boys. The role of choroidal thickness on the development of refraction should be investigated in prospective studies.

KW - Myopia

KW - Choroid

KW - Physical activity

KW - Children

M3 - Poster

ER -

Lundberg K, Jacobsen N, Vestergaard AH, Goldschmidt E, Peto T, Larsen M et al. Choroidal thickness and myopia in relation to physical activity during childhood. 2017. Poster session præsenteret på Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, USA.