Childhood body mass index in relation to subsequent risk of type 1 diabetes

A Danish cohort study

Julie C Antvorskov, Lise Aunsholt, Karsten Buschard, Michael Gamborg, Kurt Kristensen, Jesper Johannesen, Thorkild I A Sørensen, Jannet Svensson

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The incidence of type 1 diabetes (T1D) is increasing, and obesity may be a contributing factor by increasing the risk and accelerating the onset. We investigated the relation between childhood body mass index z-scores (BMIz) and the later risk of T1D, including association with age at onset of T1D. The study included 238 cases and 10 147 controls selected from the Copenhagen School Health Record Register (CSHRR). Cases of T1D were identified in the Danish Registry of Childhood and Adolescent Diabetes and 2 regional studies and linked to CSHRR. Using conditional logistic regression models, the association of childhood prediagnostic BMIz at 7 and 13 years of age and changes between these ages with subsequent risk (odds ratio, OR) of T1D was estimated. A greater BMIz at 7 and 13 years of age was associated with increased risk of T1D with OR of 1.23 (confidence interval, CI 1.09-1.37; P = .0001) and 1.20 (CI 1.04-1.40; P = .016), respectively. The risk was increased by upward changes in z-scores from birth to 7 years (OR=1.21, P = .003) and from 7 to 13 years of age (OR=1.95, P = .023), but in the latter age interval also by a decline in BMIz (OR = 1.91, P = .034). There were no associations between BMIz at 7 and 13 years of age and the age of onset (P = .34 and P = .42, respectively). Increased BMIz is associated with a moderate increase in risk of T1D, but with no relation to age at onset within the analyzed age range. Increased BMIz over time is unlikely to explain the rising incidence of T1D.

OriginalsprogEngelsk
TidsskriftPediatric Diabetes
Vol/bind19
Udgave nummer2
Sider (fra-til)265-270
ISSN1399-543X
DOI
StatusUdgivet - mar. 2018

Fingeraftryk

Body Mass Index
Cohort Studies
Odds Ratio
Age of Onset
School Health Services
Logistic Models
Incidence
Type 2 Diabetes Mellitus
Registries
Confidence Intervals

Citer dette

Antvorskov, J. C., Aunsholt, L., Buschard, K., Gamborg, M., Kristensen, K., Johannesen, J., ... Svensson, J. (2018). Childhood body mass index in relation to subsequent risk of type 1 diabetes: A Danish cohort study. Pediatric Diabetes, 19(2), 265-270. https://doi.org/10.1111/pedi.12568
Antvorskov, Julie C ; Aunsholt, Lise ; Buschard, Karsten ; Gamborg, Michael ; Kristensen, Kurt ; Johannesen, Jesper ; Sørensen, Thorkild I A ; Svensson, Jannet. / Childhood body mass index in relation to subsequent risk of type 1 diabetes : A Danish cohort study. I: Pediatric Diabetes. 2018 ; Bind 19, Nr. 2. s. 265-270.
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title = "Childhood body mass index in relation to subsequent risk of type 1 diabetes: A Danish cohort study",
abstract = "The incidence of type 1 diabetes (T1D) is increasing, and obesity may be a contributing factor by increasing the risk and accelerating the onset. We investigated the relation between childhood body mass index z-scores (BMIz) and the later risk of T1D, including association with age at onset of T1D. The study included 238 cases and 10 147 controls selected from the Copenhagen School Health Record Register (CSHRR). Cases of T1D were identified in the Danish Registry of Childhood and Adolescent Diabetes and 2 regional studies and linked to CSHRR. Using conditional logistic regression models, the association of childhood prediagnostic BMIz at 7 and 13 years of age and changes between these ages with subsequent risk (odds ratio, OR) of T1D was estimated. A greater BMIz at 7 and 13 years of age was associated with increased risk of T1D with OR of 1.23 (confidence interval, CI 1.09-1.37; P = .0001) and 1.20 (CI 1.04-1.40; P = .016), respectively. The risk was increased by upward changes in z-scores from birth to 7 years (OR=1.21, P = .003) and from 7 to 13 years of age (OR=1.95, P = .023), but in the latter age interval also by a decline in BMIz (OR = 1.91, P = .034). There were no associations between BMIz at 7 and 13 years of age and the age of onset (P = .34 and P = .42, respectively). Increased BMIz is associated with a moderate increase in risk of T1D, but with no relation to age at onset within the analyzed age range. Increased BMIz over time is unlikely to explain the rising incidence of T1D.",
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Antvorskov, JC, Aunsholt, L, Buschard, K, Gamborg, M, Kristensen, K, Johannesen, J, Sørensen, TIA & Svensson, J 2018, 'Childhood body mass index in relation to subsequent risk of type 1 diabetes: A Danish cohort study', Pediatric Diabetes, bind 19, nr. 2, s. 265-270. https://doi.org/10.1111/pedi.12568

Childhood body mass index in relation to subsequent risk of type 1 diabetes : A Danish cohort study. / Antvorskov, Julie C; Aunsholt, Lise; Buschard, Karsten; Gamborg, Michael; Kristensen, Kurt; Johannesen, Jesper; Sørensen, Thorkild I A; Svensson, Jannet.

I: Pediatric Diabetes, Bind 19, Nr. 2, 03.2018, s. 265-270.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Childhood body mass index in relation to subsequent risk of type 1 diabetes

T2 - A Danish cohort study

AU - Antvorskov, Julie C

AU - Aunsholt, Lise

AU - Buschard, Karsten

AU - Gamborg, Michael

AU - Kristensen, Kurt

AU - Johannesen, Jesper

AU - Sørensen, Thorkild I A

AU - Svensson, Jannet

N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2018/3

Y1 - 2018/3

N2 - The incidence of type 1 diabetes (T1D) is increasing, and obesity may be a contributing factor by increasing the risk and accelerating the onset. We investigated the relation between childhood body mass index z-scores (BMIz) and the later risk of T1D, including association with age at onset of T1D. The study included 238 cases and 10 147 controls selected from the Copenhagen School Health Record Register (CSHRR). Cases of T1D were identified in the Danish Registry of Childhood and Adolescent Diabetes and 2 regional studies and linked to CSHRR. Using conditional logistic regression models, the association of childhood prediagnostic BMIz at 7 and 13 years of age and changes between these ages with subsequent risk (odds ratio, OR) of T1D was estimated. A greater BMIz at 7 and 13 years of age was associated with increased risk of T1D with OR of 1.23 (confidence interval, CI 1.09-1.37; P = .0001) and 1.20 (CI 1.04-1.40; P = .016), respectively. The risk was increased by upward changes in z-scores from birth to 7 years (OR=1.21, P = .003) and from 7 to 13 years of age (OR=1.95, P = .023), but in the latter age interval also by a decline in BMIz (OR = 1.91, P = .034). There were no associations between BMIz at 7 and 13 years of age and the age of onset (P = .34 and P = .42, respectively). Increased BMIz is associated with a moderate increase in risk of T1D, but with no relation to age at onset within the analyzed age range. Increased BMIz over time is unlikely to explain the rising incidence of T1D.

AB - The incidence of type 1 diabetes (T1D) is increasing, and obesity may be a contributing factor by increasing the risk and accelerating the onset. We investigated the relation between childhood body mass index z-scores (BMIz) and the later risk of T1D, including association with age at onset of T1D. The study included 238 cases and 10 147 controls selected from the Copenhagen School Health Record Register (CSHRR). Cases of T1D were identified in the Danish Registry of Childhood and Adolescent Diabetes and 2 regional studies and linked to CSHRR. Using conditional logistic regression models, the association of childhood prediagnostic BMIz at 7 and 13 years of age and changes between these ages with subsequent risk (odds ratio, OR) of T1D was estimated. A greater BMIz at 7 and 13 years of age was associated with increased risk of T1D with OR of 1.23 (confidence interval, CI 1.09-1.37; P = .0001) and 1.20 (CI 1.04-1.40; P = .016), respectively. The risk was increased by upward changes in z-scores from birth to 7 years (OR=1.21, P = .003) and from 7 to 13 years of age (OR=1.95, P = .023), but in the latter age interval also by a decline in BMIz (OR = 1.91, P = .034). There were no associations between BMIz at 7 and 13 years of age and the age of onset (P = .34 and P = .42, respectively). Increased BMIz is associated with a moderate increase in risk of T1D, but with no relation to age at onset within the analyzed age range. Increased BMIz over time is unlikely to explain the rising incidence of T1D.

KW - Journal Article

KW - type 1 diabetes

KW - children

KW - accelerator hypothesis

KW - incidence

KW - BMI

KW - Diabetes Mellitus, Type 1/epidemiology

KW - Follow-Up Studies

KW - Pediatric Obesity/etiology

KW - Humans

KW - Male

KW - Risk

KW - Statistics as Topic

KW - Child Nutritional Physiological Phenomena/ethnology

KW - Incidence

KW - Female

KW - Registries

KW - Child Development

KW - Child

KW - Schools

KW - Body Mass Index

KW - Health Transition

KW - Denmark/epidemiology

KW - Adolescent

KW - Age of Onset

KW - Overweight/ethnology

KW - Cohort Studies

U2 - 10.1111/pedi.12568

DO - 10.1111/pedi.12568

M3 - Journal article

VL - 19

SP - 265

EP - 270

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

IS - 2

ER -