Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes

Marita Westhrin, Siv Helen Moen, Ida Bruun Kristensen, Glenn Buene, Anne Kærsgaard Mylin, Ingemar Turesson, Niels Abildgaard, Anders Waage, Therese Standal

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

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Resumé

Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.

OriginalsprogEngelsk
Artikelnummer21
TidsskriftBiomarker Research
Vol/bind6
Sider (fra-til)1-4
ISSN2050-7771
DOI
StatusUdgivet - 14. jun. 2018

Fingeraftryk

Stromal Cells
Adipocytes
Paracrine Communication
Mesenchymal Stromal Cells
Serum

Citer dette

Westhrin, M., Moen, S. H., Kristensen, I. B., Buene, G., Mylin, A. K., Turesson, I., ... Standal, T. (2018). Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes. Biomarker Research, 6, 1-4. [21]. https://doi.org/10.1186/s40364-018-0134-y
Westhrin, Marita ; Moen, Siv Helen ; Kristensen, Ida Bruun ; Buene, Glenn ; Mylin, Anne Kærsgaard ; Turesson, Ingemar ; Abildgaard, Niels ; Waage, Anders ; Standal, Therese. / Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes. I: Biomarker Research. 2018 ; Bind 6. s. 1-4.
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abstract = "Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.",
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Westhrin, M, Moen, SH, Kristensen, IB, Buene, G, Mylin, AK, Turesson, I, Abildgaard, N, Waage, A & Standal, T 2018, 'Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes', Biomarker Research, bind 6, 21, s. 1-4. https://doi.org/10.1186/s40364-018-0134-y

Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes. / Westhrin, Marita; Moen, Siv Helen; Kristensen, Ida Bruun; Buene, Glenn; Mylin, Anne Kærsgaard; Turesson, Ingemar; Abildgaard, Niels; Waage, Anders; Standal, Therese.

I: Biomarker Research, Bind 6, 21, 14.06.2018, s. 1-4.

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

TY - JOUR

T1 - Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes

AU - Westhrin, Marita

AU - Moen, Siv Helen

AU - Kristensen, Ida Bruun

AU - Buene, Glenn

AU - Mylin, Anne Kærsgaard

AU - Turesson, Ingemar

AU - Abildgaard, Niels

AU - Waage, Anders

AU - Standal, Therese

PY - 2018/6/14

Y1 - 2018/6/14

N2 - Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.

AB - Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.

KW - Adipocyte

KW - Chemerin

KW - Multiple myeloma

KW - Stromal cell

U2 - 10.1186/s40364-018-0134-y

DO - 10.1186/s40364-018-0134-y

M3 - Comment/debate

C2 - 29946468

VL - 6

SP - 1

EP - 4

JO - Biomarker Research

JF - Biomarker Research

SN - 2050-7771

M1 - 21

ER -