Characterization of drug-related problems identified by clinical pharmacy staff at Danish hospitals

Lene Juel Kjeldsen, Trine Birkholm, Hanne Fischer, Trine Graabæk, Karina Porsborg Kibsdal, Lene Vestergaard Ravn-Nielsen, Tania Holtum Truelshøj

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background In 2010, a database of drug related problems (DRPs) was implemented to assist clinical pharmacy staff in documenting clinical pharmacy activities locally. A study of quality, reliability and generalisability showed that national analyses of the data could be conducted. Analyses at the national level may help identify and prevent DRPs by performing national interventions. Objective The aim of the study was to explore the DRP characteristics as documented by clinical pharmacy staff at hospital pharmacies in the Danish DRP-database during a 3-year period. Setting Danish hospital pharmacies. Method Data documented in the DRP-database during the initial 3 years after implementation were analyzed retrospectively. The DRP-database contains DRPs reported at hospitals by clinical pharmacy staff. The analyses focused on DRP categories, implementation rates and drugs associated with the DRPs. Main outcome measure Characteristics of DRPs. Results In total, 72,044 DRPs were documented in the DRP-database during the first 3 years of implementation, and the number of documented DRPs increased every year. An overall stable implementation rate of approximately 58 % was identified. The DRPs identified were multi-facetted, however evenly distributed for each of the 3 years. The most frequently identified DRP categories were: "Dose", followed by "Nonadherence to guidelines" and "Supplement to treatment". The highest implementation rates were found for the following DRP categories: "Non-adherence to guidelines" (79 %) followed by "Therapeutic duplication" (73 %) and "Dosing time and interval" (70 %). Even though the top 25 drugs were involved in 58 % of all DRPs, multiple drugs were associated with DRPs. The drugs most frequently involved in DRPs were paracetamol (4.6 % of all DRPs), simvastatin (3.0 %), lansoprazole (2.7 %), morphine (2.6 %) and alendronic acid (2.4 %). Conclusions The study found that a national database on DRPs contained multi-facetted DRPs, however evenly distributed for each of the 3 years. Even though the top 25 drugs were involved in 58 % of all DRPs, multiple drugs were associated with DRPs. The study emphasizes the importance of detecting and intervening for DRPs.

OriginalsprogEngelsk
TidsskriftInternational Journal of Clinical Pharmacy
Vol/bind36
Udgave nummer4
Sider (fra-til)734-41
ISSN2210-7703
DOI
StatusUdgivet - aug. 2014

Fingeraftryk

Pharmaceutical Preparations
Pharmaceutical Databases
Pharmacies
Databases
Guidelines
Lansoprazole
Simvastatin
Acetaminophen
Morphine
Outcome Assessment (Health Care)

Citer dette

Kjeldsen, L. J., Birkholm, T., Fischer, H., Graabæk, T., Kibsdal, K. P., Ravn-Nielsen, L. V., & Truelshøj, T. H. (2014). Characterization of drug-related problems identified by clinical pharmacy staff at Danish hospitals. International Journal of Clinical Pharmacy, 36(4), 734-41. https://doi.org/10.1007/s11096-014-9939-4
Kjeldsen, Lene Juel ; Birkholm, Trine ; Fischer, Hanne ; Graabæk, Trine ; Kibsdal, Karina Porsborg ; Ravn-Nielsen, Lene Vestergaard ; Truelshøj, Tania Holtum. / Characterization of drug-related problems identified by clinical pharmacy staff at Danish hospitals. I: International Journal of Clinical Pharmacy. 2014 ; Bind 36, Nr. 4. s. 734-41.
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title = "Characterization of drug-related problems identified by clinical pharmacy staff at Danish hospitals",
abstract = "Background In 2010, a database of drug related problems (DRPs) was implemented to assist clinical pharmacy staff in documenting clinical pharmacy activities locally. A study of quality, reliability and generalisability showed that national analyses of the data could be conducted. Analyses at the national level may help identify and prevent DRPs by performing national interventions. Objective The aim of the study was to explore the DRP characteristics as documented by clinical pharmacy staff at hospital pharmacies in the Danish DRP-database during a 3-year period. Setting Danish hospital pharmacies. Method Data documented in the DRP-database during the initial 3 years after implementation were analyzed retrospectively. The DRP-database contains DRPs reported at hospitals by clinical pharmacy staff. The analyses focused on DRP categories, implementation rates and drugs associated with the DRPs. Main outcome measure Characteristics of DRPs. Results In total, 72,044 DRPs were documented in the DRP-database during the first 3 years of implementation, and the number of documented DRPs increased every year. An overall stable implementation rate of approximately 58 {\%} was identified. The DRPs identified were multi-facetted, however evenly distributed for each of the 3 years. The most frequently identified DRP categories were: {"}Dose{"}, followed by {"}Nonadherence to guidelines{"} and {"}Supplement to treatment{"}. The highest implementation rates were found for the following DRP categories: {"}Non-adherence to guidelines{"} (79 {\%}) followed by {"}Therapeutic duplication{"} (73 {\%}) and {"}Dosing time and interval{"} (70 {\%}). Even though the top 25 drugs were involved in 58 {\%} of all DRPs, multiple drugs were associated with DRPs. The drugs most frequently involved in DRPs were paracetamol (4.6 {\%} of all DRPs), simvastatin (3.0 {\%}), lansoprazole (2.7 {\%}), morphine (2.6 {\%}) and alendronic acid (2.4 {\%}). Conclusions The study found that a national database on DRPs contained multi-facetted DRPs, however evenly distributed for each of the 3 years. Even though the top 25 drugs were involved in 58 {\%} of all DRPs, multiple drugs were associated with DRPs. The study emphasizes the importance of detecting and intervening for DRPs.",
author = "Kjeldsen, {Lene Juel} and Trine Birkholm and Hanne Fischer and Trine Graab{\ae}k and Kibsdal, {Karina Porsborg} and Ravn-Nielsen, {Lene Vestergaard} and Truelsh{\o}j, {Tania Holtum}",
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pages = "734--41",
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Kjeldsen, LJ, Birkholm, T, Fischer, H, Graabæk, T, Kibsdal, KP, Ravn-Nielsen, LV & Truelshøj, TH 2014, 'Characterization of drug-related problems identified by clinical pharmacy staff at Danish hospitals', International Journal of Clinical Pharmacy, bind 36, nr. 4, s. 734-41. https://doi.org/10.1007/s11096-014-9939-4

Characterization of drug-related problems identified by clinical pharmacy staff at Danish hospitals. / Kjeldsen, Lene Juel; Birkholm, Trine; Fischer, Hanne; Graabæk, Trine; Kibsdal, Karina Porsborg; Ravn-Nielsen, Lene Vestergaard; Truelshøj, Tania Holtum.

I: International Journal of Clinical Pharmacy, Bind 36, Nr. 4, 08.2014, s. 734-41.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Characterization of drug-related problems identified by clinical pharmacy staff at Danish hospitals

AU - Kjeldsen, Lene Juel

AU - Birkholm, Trine

AU - Fischer, Hanne

AU - Graabæk, Trine

AU - Kibsdal, Karina Porsborg

AU - Ravn-Nielsen, Lene Vestergaard

AU - Truelshøj, Tania Holtum

PY - 2014/8

Y1 - 2014/8

N2 - Background In 2010, a database of drug related problems (DRPs) was implemented to assist clinical pharmacy staff in documenting clinical pharmacy activities locally. A study of quality, reliability and generalisability showed that national analyses of the data could be conducted. Analyses at the national level may help identify and prevent DRPs by performing national interventions. Objective The aim of the study was to explore the DRP characteristics as documented by clinical pharmacy staff at hospital pharmacies in the Danish DRP-database during a 3-year period. Setting Danish hospital pharmacies. Method Data documented in the DRP-database during the initial 3 years after implementation were analyzed retrospectively. The DRP-database contains DRPs reported at hospitals by clinical pharmacy staff. The analyses focused on DRP categories, implementation rates and drugs associated with the DRPs. Main outcome measure Characteristics of DRPs. Results In total, 72,044 DRPs were documented in the DRP-database during the first 3 years of implementation, and the number of documented DRPs increased every year. An overall stable implementation rate of approximately 58 % was identified. The DRPs identified were multi-facetted, however evenly distributed for each of the 3 years. The most frequently identified DRP categories were: "Dose", followed by "Nonadherence to guidelines" and "Supplement to treatment". The highest implementation rates were found for the following DRP categories: "Non-adherence to guidelines" (79 %) followed by "Therapeutic duplication" (73 %) and "Dosing time and interval" (70 %). Even though the top 25 drugs were involved in 58 % of all DRPs, multiple drugs were associated with DRPs. The drugs most frequently involved in DRPs were paracetamol (4.6 % of all DRPs), simvastatin (3.0 %), lansoprazole (2.7 %), morphine (2.6 %) and alendronic acid (2.4 %). Conclusions The study found that a national database on DRPs contained multi-facetted DRPs, however evenly distributed for each of the 3 years. Even though the top 25 drugs were involved in 58 % of all DRPs, multiple drugs were associated with DRPs. The study emphasizes the importance of detecting and intervening for DRPs.

AB - Background In 2010, a database of drug related problems (DRPs) was implemented to assist clinical pharmacy staff in documenting clinical pharmacy activities locally. A study of quality, reliability and generalisability showed that national analyses of the data could be conducted. Analyses at the national level may help identify and prevent DRPs by performing national interventions. Objective The aim of the study was to explore the DRP characteristics as documented by clinical pharmacy staff at hospital pharmacies in the Danish DRP-database during a 3-year period. Setting Danish hospital pharmacies. Method Data documented in the DRP-database during the initial 3 years after implementation were analyzed retrospectively. The DRP-database contains DRPs reported at hospitals by clinical pharmacy staff. The analyses focused on DRP categories, implementation rates and drugs associated with the DRPs. Main outcome measure Characteristics of DRPs. Results In total, 72,044 DRPs were documented in the DRP-database during the first 3 years of implementation, and the number of documented DRPs increased every year. An overall stable implementation rate of approximately 58 % was identified. The DRPs identified were multi-facetted, however evenly distributed for each of the 3 years. The most frequently identified DRP categories were: "Dose", followed by "Nonadherence to guidelines" and "Supplement to treatment". The highest implementation rates were found for the following DRP categories: "Non-adherence to guidelines" (79 %) followed by "Therapeutic duplication" (73 %) and "Dosing time and interval" (70 %). Even though the top 25 drugs were involved in 58 % of all DRPs, multiple drugs were associated with DRPs. The drugs most frequently involved in DRPs were paracetamol (4.6 % of all DRPs), simvastatin (3.0 %), lansoprazole (2.7 %), morphine (2.6 %) and alendronic acid (2.4 %). Conclusions The study found that a national database on DRPs contained multi-facetted DRPs, however evenly distributed for each of the 3 years. Even though the top 25 drugs were involved in 58 % of all DRPs, multiple drugs were associated with DRPs. The study emphasizes the importance of detecting and intervening for DRPs.

U2 - 10.1007/s11096-014-9939-4

DO - 10.1007/s11096-014-9939-4

M3 - Journal article

C2 - 24736894

VL - 36

SP - 734

EP - 741

JO - International Journal of Clinical Pharmacy

JF - International Journal of Clinical Pharmacy

SN - 2210-7703

IS - 4

ER -