Characteristics of patients with cervical cancer during pregnancy

a multicenter matched cohort study. An initiative from the International Network on Cancer, Infertility and Pregnancy

Michael J Halaska, Catherine Uzan, Sileny N Han, Robert Fruscio, Karina Dahl Steffensen, Ben Van Calster, Hana Stankusova, Martina Delle Marchette, Astrid Mephon, Roman Rouzier, Petronella O Witteveen, Patrizia Vergani, Kristina Van Calsteren, Lukas Rob, Frederic Amant*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Treatment of cervical cancer during pregnancy is often complex and challenging. This study aimed to analyze current patterns of practice in the management of pregnant patients diagnosed with cervical cancer.

METHODS: This was a matched cohort study comprising patients managed for cervical cancer during pregnancy from six European centers. Patient information was retrieved from the dataset of the International Network for Cancer, Infertility and Pregnancy from 1990 to 2012. Each center matched its patients with two non-pregnant controls for age (±5 years) and International Federation of Gynecology and Obstetrics (FIGO) 2009 stage. Information on age, histological type, grade, lymphovascular space invasion, stage, tumor size, method of diagnosis, site of recurrence, delivery, date of recurrence, and date of death was recorded. Progression-free survival was compared using multivariable Cox proportional hazards regression.

RESULTS: A total of 132 pregnant patients and 256 controls were analyzed. The pregnant patients (median age 34 years, range 21-43) were diagnosed at a median gestational age of 18.4 weeks of pregnancy (range 7-39). Stage distribution during pregnancy was 14.4% for stage IA, 47.0% for IB1, 18.9% for IB2, and 19.7% for II-IV. For treatment during pregnancy, 17.4% of the patients underwent surgery, 16.7% received neoadjuvant chemotherapy, 26.5% delayed their treatment, 12.9% had a premature delivery, and 26.5% had their pregnancy terminated. Median follow-up was 84 months (67 months for pregnant and 95 months for non-pregnant patients). The unadjusted hazard ratio of pregnancy for progression-free survival was 1.18 (95% confidence interval 0.74 to 1.88).

CONCLUSION: Surgery and chemotherapy is increasingly used in the management of pregnant patients with cervical cancer and prognosis is similar to that of non-pregnant patients.

OriginalsprogEngelsk
TidsskriftInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Vol/bind29
Udgave nummer4
Sider (fra-til)676-682
ISSN1048-891X
DOI
StatusUdgivet - 7. maj 2019

Fingeraftryk

Uterine Cervical Neoplasms
Infertility
Cohort Studies
Neoplasms
Disease-Free Survival
Practice Management
Gynecology
Gestational Age
Obstetrics
Confidence Intervals

Citer dette

Halaska, Michael J ; Uzan, Catherine ; Han, Sileny N ; Fruscio, Robert ; Dahl Steffensen, Karina ; Van Calster, Ben ; Stankusova, Hana ; Delle Marchette, Martina ; Mephon, Astrid ; Rouzier, Roman ; Witteveen, Petronella O ; Vergani, Patrizia ; Van Calsteren, Kristina ; Rob, Lukas ; Amant, Frederic. / Characteristics of patients with cervical cancer during pregnancy : a multicenter matched cohort study. An initiative from the International Network on Cancer, Infertility and Pregnancy. I: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2019 ; Bind 29, Nr. 4. s. 676-682.
@article{c4fd736e3cd84d11ae92675802abed3e,
title = "Characteristics of patients with cervical cancer during pregnancy: a multicenter matched cohort study. An initiative from the International Network on Cancer, Infertility and Pregnancy",
abstract = "BACKGROUND: Treatment of cervical cancer during pregnancy is often complex and challenging. This study aimed to analyze current patterns of practice in the management of pregnant patients diagnosed with cervical cancer.METHODS: This was a matched cohort study comprising patients managed for cervical cancer during pregnancy from six European centers. Patient information was retrieved from the dataset of the International Network for Cancer, Infertility and Pregnancy from 1990 to 2012. Each center matched its patients with two non-pregnant controls for age (±5 years) and International Federation of Gynecology and Obstetrics (FIGO) 2009 stage. Information on age, histological type, grade, lymphovascular space invasion, stage, tumor size, method of diagnosis, site of recurrence, delivery, date of recurrence, and date of death was recorded. Progression-free survival was compared using multivariable Cox proportional hazards regression.RESULTS: A total of 132 pregnant patients and 256 controls were analyzed. The pregnant patients (median age 34 years, range 21-43) were diagnosed at a median gestational age of 18.4 weeks of pregnancy (range 7-39). Stage distribution during pregnancy was 14.4{\%} for stage IA, 47.0{\%} for IB1, 18.9{\%} for IB2, and 19.7{\%} for II-IV. For treatment during pregnancy, 17.4{\%} of the patients underwent surgery, 16.7{\%} received neoadjuvant chemotherapy, 26.5{\%} delayed their treatment, 12.9{\%} had a premature delivery, and 26.5{\%} had their pregnancy terminated. Median follow-up was 84 months (67 months for pregnant and 95 months for non-pregnant patients). The unadjusted hazard ratio of pregnancy for progression-free survival was 1.18 (95{\%} confidence interval 0.74 to 1.88).CONCLUSION: Surgery and chemotherapy is increasingly used in the management of pregnant patients with cervical cancer and prognosis is similar to that of non-pregnant patients.",
author = "Halaska, {Michael J} and Catherine Uzan and Han, {Sileny N} and Robert Fruscio and {Dahl Steffensen}, Karina and {Van Calster}, Ben and Hana Stankusova and {Delle Marchette}, Martina and Astrid Mephon and Roman Rouzier and Witteveen, {Petronella O} and Patrizia Vergani and {Van Calsteren}, Kristina and Lukas Rob and Frederic Amant",
note = "{\circledC} IGCS and ESGO [2019]. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = "5",
day = "7",
doi = "10.1136/ijgc-2018-000103",
language = "English",
volume = "29",
pages = "676--682",
journal = "International Journal of Gynecological Cancer",
issn = "1048-891X",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "4",

}

Characteristics of patients with cervical cancer during pregnancy : a multicenter matched cohort study. An initiative from the International Network on Cancer, Infertility and Pregnancy. / Halaska, Michael J; Uzan, Catherine; Han, Sileny N; Fruscio, Robert; Dahl Steffensen, Karina; Van Calster, Ben; Stankusova, Hana; Delle Marchette, Martina; Mephon, Astrid; Rouzier, Roman; Witteveen, Petronella O; Vergani, Patrizia; Van Calsteren, Kristina; Rob, Lukas; Amant, Frederic.

I: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Bind 29, Nr. 4, 07.05.2019, s. 676-682.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Characteristics of patients with cervical cancer during pregnancy

T2 - a multicenter matched cohort study. An initiative from the International Network on Cancer, Infertility and Pregnancy

AU - Halaska, Michael J

AU - Uzan, Catherine

AU - Han, Sileny N

AU - Fruscio, Robert

AU - Dahl Steffensen, Karina

AU - Van Calster, Ben

AU - Stankusova, Hana

AU - Delle Marchette, Martina

AU - Mephon, Astrid

AU - Rouzier, Roman

AU - Witteveen, Petronella O

AU - Vergani, Patrizia

AU - Van Calsteren, Kristina

AU - Rob, Lukas

AU - Amant, Frederic

N1 - © IGCS and ESGO [2019]. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019/5/7

Y1 - 2019/5/7

N2 - BACKGROUND: Treatment of cervical cancer during pregnancy is often complex and challenging. This study aimed to analyze current patterns of practice in the management of pregnant patients diagnosed with cervical cancer.METHODS: This was a matched cohort study comprising patients managed for cervical cancer during pregnancy from six European centers. Patient information was retrieved from the dataset of the International Network for Cancer, Infertility and Pregnancy from 1990 to 2012. Each center matched its patients with two non-pregnant controls for age (±5 years) and International Federation of Gynecology and Obstetrics (FIGO) 2009 stage. Information on age, histological type, grade, lymphovascular space invasion, stage, tumor size, method of diagnosis, site of recurrence, delivery, date of recurrence, and date of death was recorded. Progression-free survival was compared using multivariable Cox proportional hazards regression.RESULTS: A total of 132 pregnant patients and 256 controls were analyzed. The pregnant patients (median age 34 years, range 21-43) were diagnosed at a median gestational age of 18.4 weeks of pregnancy (range 7-39). Stage distribution during pregnancy was 14.4% for stage IA, 47.0% for IB1, 18.9% for IB2, and 19.7% for II-IV. For treatment during pregnancy, 17.4% of the patients underwent surgery, 16.7% received neoadjuvant chemotherapy, 26.5% delayed their treatment, 12.9% had a premature delivery, and 26.5% had their pregnancy terminated. Median follow-up was 84 months (67 months for pregnant and 95 months for non-pregnant patients). The unadjusted hazard ratio of pregnancy for progression-free survival was 1.18 (95% confidence interval 0.74 to 1.88).CONCLUSION: Surgery and chemotherapy is increasingly used in the management of pregnant patients with cervical cancer and prognosis is similar to that of non-pregnant patients.

AB - BACKGROUND: Treatment of cervical cancer during pregnancy is often complex and challenging. This study aimed to analyze current patterns of practice in the management of pregnant patients diagnosed with cervical cancer.METHODS: This was a matched cohort study comprising patients managed for cervical cancer during pregnancy from six European centers. Patient information was retrieved from the dataset of the International Network for Cancer, Infertility and Pregnancy from 1990 to 2012. Each center matched its patients with two non-pregnant controls for age (±5 years) and International Federation of Gynecology and Obstetrics (FIGO) 2009 stage. Information on age, histological type, grade, lymphovascular space invasion, stage, tumor size, method of diagnosis, site of recurrence, delivery, date of recurrence, and date of death was recorded. Progression-free survival was compared using multivariable Cox proportional hazards regression.RESULTS: A total of 132 pregnant patients and 256 controls were analyzed. The pregnant patients (median age 34 years, range 21-43) were diagnosed at a median gestational age of 18.4 weeks of pregnancy (range 7-39). Stage distribution during pregnancy was 14.4% for stage IA, 47.0% for IB1, 18.9% for IB2, and 19.7% for II-IV. For treatment during pregnancy, 17.4% of the patients underwent surgery, 16.7% received neoadjuvant chemotherapy, 26.5% delayed their treatment, 12.9% had a premature delivery, and 26.5% had their pregnancy terminated. Median follow-up was 84 months (67 months for pregnant and 95 months for non-pregnant patients). The unadjusted hazard ratio of pregnancy for progression-free survival was 1.18 (95% confidence interval 0.74 to 1.88).CONCLUSION: Surgery and chemotherapy is increasingly used in the management of pregnant patients with cervical cancer and prognosis is similar to that of non-pregnant patients.

U2 - 10.1136/ijgc-2018-000103

DO - 10.1136/ijgc-2018-000103

M3 - Journal article

VL - 29

SP - 676

EP - 682

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

SN - 1048-891X

IS - 4

ER -