Changing pattern of malaria in Bissau, Guinea Bissau

Amabelia Rodrigues, Joanna Armstrong Schellenberg, Poul-Erik Kofoed, Peter Aaby, Brian Greenwood

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: Mar
OriginalsprogEngelsk
TidsskriftTropical Medicine & International Health
Vol/bind13
Udgave nummer3
Sider (fra-til)410-417
Antal sider7
ISSN1360-2276
DOI
StatusUdgivet - 1. mar. 2008

Fingeraftryk

Guinea-Bissau
Malaria
Parasitemia
Health
Hospital Outpatient Clinics
Hospitalized Child
Health Facilities

Citer dette

Rodrigues, Amabelia ; Schellenberg, Joanna Armstrong ; Kofoed, Poul-Erik ; Aaby, Peter ; Greenwood, Brian. / Changing pattern of malaria in Bissau, Guinea Bissau. I: Tropical Medicine & International Health. 2008 ; Bind 13, Nr. 3. s. 410-417.
@article{620306a0411f11dd9fbe000ea68e967b,
title = "Changing pattern of malaria in Bissau, Guinea Bissau",
abstract = "OBJECTIVE: To describe the epidemiology of malaria in Guinea-Bissau, in view of the fact that more funds are available now for malaria control in the country. METHODS: From May 2003 to May 2004, surveillance for malaria was conducted among children less than 5 years of age at three health centres covering the study area of the Bandim Health Project (BHP) and at the outpatient clinic of the national hospital in Bissau. Cross-sectional surveys were conducted in the community in different malaria seasons. RESULTS: Malaria was overdiagnosed in both health centres and hospital. Sixty-four per cent of the children who presented at a health centre were clinically diagnosed with malaria, but only 13{\%} of outpatient children who tested for malaria had malaria parasitaemia. Only 44{\%} (963/2193) of children admitted to hospital with a diagnosis of malaria had parasitaemia. The proportion of positive cases increased with age. Among hospitalized children with malaria parasitaemia, those less than 2 years old were more likely to have moderate anaemia (RR = 1.27; 95{\%} CI: 1.02-1.56) (P = 0.03) or severe anaemia (RR = 1.67; 95{\%} CI: 1.25-2.24) (P = 0.0005) than older children. The prevalence of malaria parasitaemia in the community was low (3{\%}, 53/1926). CONCLUSION: In Bissau, the prevalence of malaria parasitaemia in the community is now low and malaria is over-diagnosed in health facilities. Laboratory support will be essential to avoid unnecessary use of the artemisinin combination therapy which is now being introduced as first-line treatment in Bissau with support from the Global Fund.",
keywords = "Anemia, Iron-Deficiency, Child, Preschool, Cross-Sectional Studies, Female, Guinea-Bissau, Humans, Infant, Malaria, Falciparum, Male, Parasitemia",
author = "Amabelia Rodrigues and Schellenberg, {Joanna Armstrong} and Poul-Erik Kofoed and Peter Aaby and Brian Greenwood",
year = "2008",
month = "3",
day = "1",
doi = "10.1111/j.1365-3156.2008.02016.x",
language = "English",
volume = "13",
pages = "410--417",
journal = "Tropical Medicine & International Health",
issn = "1360-2276",
publisher = "Wiley-Blackwell",
number = "3",

}

Changing pattern of malaria in Bissau, Guinea Bissau. / Rodrigues, Amabelia; Schellenberg, Joanna Armstrong; Kofoed, Poul-Erik; Aaby, Peter; Greenwood, Brian.

I: Tropical Medicine & International Health, Bind 13, Nr. 3, 01.03.2008, s. 410-417.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Changing pattern of malaria in Bissau, Guinea Bissau

AU - Rodrigues, Amabelia

AU - Schellenberg, Joanna Armstrong

AU - Kofoed, Poul-Erik

AU - Aaby, Peter

AU - Greenwood, Brian

PY - 2008/3/1

Y1 - 2008/3/1

N2 - OBJECTIVE: To describe the epidemiology of malaria in Guinea-Bissau, in view of the fact that more funds are available now for malaria control in the country. METHODS: From May 2003 to May 2004, surveillance for malaria was conducted among children less than 5 years of age at three health centres covering the study area of the Bandim Health Project (BHP) and at the outpatient clinic of the national hospital in Bissau. Cross-sectional surveys were conducted in the community in different malaria seasons. RESULTS: Malaria was overdiagnosed in both health centres and hospital. Sixty-four per cent of the children who presented at a health centre were clinically diagnosed with malaria, but only 13% of outpatient children who tested for malaria had malaria parasitaemia. Only 44% (963/2193) of children admitted to hospital with a diagnosis of malaria had parasitaemia. The proportion of positive cases increased with age. Among hospitalized children with malaria parasitaemia, those less than 2 years old were more likely to have moderate anaemia (RR = 1.27; 95% CI: 1.02-1.56) (P = 0.03) or severe anaemia (RR = 1.67; 95% CI: 1.25-2.24) (P = 0.0005) than older children. The prevalence of malaria parasitaemia in the community was low (3%, 53/1926). CONCLUSION: In Bissau, the prevalence of malaria parasitaemia in the community is now low and malaria is over-diagnosed in health facilities. Laboratory support will be essential to avoid unnecessary use of the artemisinin combination therapy which is now being introduced as first-line treatment in Bissau with support from the Global Fund.

AB - OBJECTIVE: To describe the epidemiology of malaria in Guinea-Bissau, in view of the fact that more funds are available now for malaria control in the country. METHODS: From May 2003 to May 2004, surveillance for malaria was conducted among children less than 5 years of age at three health centres covering the study area of the Bandim Health Project (BHP) and at the outpatient clinic of the national hospital in Bissau. Cross-sectional surveys were conducted in the community in different malaria seasons. RESULTS: Malaria was overdiagnosed in both health centres and hospital. Sixty-four per cent of the children who presented at a health centre were clinically diagnosed with malaria, but only 13% of outpatient children who tested for malaria had malaria parasitaemia. Only 44% (963/2193) of children admitted to hospital with a diagnosis of malaria had parasitaemia. The proportion of positive cases increased with age. Among hospitalized children with malaria parasitaemia, those less than 2 years old were more likely to have moderate anaemia (RR = 1.27; 95% CI: 1.02-1.56) (P = 0.03) or severe anaemia (RR = 1.67; 95% CI: 1.25-2.24) (P = 0.0005) than older children. The prevalence of malaria parasitaemia in the community was low (3%, 53/1926). CONCLUSION: In Bissau, the prevalence of malaria parasitaemia in the community is now low and malaria is over-diagnosed in health facilities. Laboratory support will be essential to avoid unnecessary use of the artemisinin combination therapy which is now being introduced as first-line treatment in Bissau with support from the Global Fund.

KW - Anemia, Iron-Deficiency

KW - Child, Preschool

KW - Cross-Sectional Studies

KW - Female

KW - Guinea-Bissau

KW - Humans

KW - Infant

KW - Malaria, Falciparum

KW - Male

KW - Parasitemia

U2 - 10.1111/j.1365-3156.2008.02016.x

DO - 10.1111/j.1365-3156.2008.02016.x

M3 - Journal article

VL - 13

SP - 410

EP - 417

JO - Tropical Medicine & International Health

JF - Tropical Medicine & International Health

SN - 1360-2276

IS - 3

ER -