Changing circadian variation of transient myocardial ischemia during the first year after a first acute myocardial infarction

H Mickley, P Pless, J R Nielsen, M Møller

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 1992-Nov-1
OriginalsprogEngelsk
TidsskriftAmerican Journal of Cardiology
Vol/bind70
Udgave nummer13
Sider (fra-til)1117-22
Antal sider5
ISSN0002-9149
StatusUdgivet - 1. nov. 1992

Fingeraftryk

Ambulatory Monitoring
Periodicity
PM 40

Citer dette

@article{5849192046fd11df937d000ea68e967b,
title = "Changing circadian variation of transient myocardial ischemia during the first year after a first acute myocardial infarction",
abstract = "In a consecutive series of 123 men (aged 55 +/- 8 years) with a recent first acute myocardial infarction (AMI), 24-hour ambulatory ST-segment monitoring was performed early after discharge (day 11 +/- 5), 6 months (day 185 +/- 6) and 1 year (day 368 +/- 8) after AMI. No difference in the prevalence of transient myocardial ischemia was found between the 3 recordings (17, 17 and 20{\%}), and most ischemic episodes were silent (98, 100 and 97{\%}). In the early postinfarction period, a peak of ischemic activity was demonstrated between 6 P.M. and midnight (40 of 93 episodes [43{\%}]). Over time, the maximal occurrence of ischemia gradually advanced toward the morning hours with a peak activity between 6 A.M. and noon at 1-year follow-up (32 of 73 episodes [44{\%}]). Significantly more patients (16 of 21 [76{\%}]) had ischemia from 6 P.M. to midnight at discharge compared with the findings 1 year later (9 of 23 patients [39{\%}]) (p < 0.03). An opposite trend was found regarding patients who exhibited ischemic episodes in the hours from 6 A.M. to noon: 10 of 21 patients (48{\%}) early after discharge versus 17 of 23 patients (74{\%}) at 1-year follow-up (p = not significant). Results from the 6-month recording displayed characteristics between the findings from discharge and 1-year ambulatory monitoring. The pathophysiologic processes underlying the observations from this study are unknown. The change in circadian periodicity could not be explained from differences in heart rate variation patterns or medical antianginal treatment among the 3 recordings.(ABSTRACT TRUNCATED AT 250 WORDS)",
keywords = "Chi-Square Distribution, Circadian Rhythm, Electrocardiography, Ambulatory, Humans, Male, Middle Aged, Myocardial Infarction, Myocardial Ischemia, Prospective Studies, Time Factors",
author = "H Mickley and P Pless and Nielsen, {J R} and M M{\o}ller",
year = "1992",
month = "11",
day = "1",
language = "English",
volume = "70",
pages = "1117--22",
journal = "The American Journal of Cardiology",
issn = "0002-9149",
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Changing circadian variation of transient myocardial ischemia during the first year after a first acute myocardial infarction. / Mickley, H; Pless, P; Nielsen, J R; Møller, M.

I: American Journal of Cardiology, Bind 70, Nr. 13, 01.11.1992, s. 1117-22.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Changing circadian variation of transient myocardial ischemia during the first year after a first acute myocardial infarction

AU - Mickley, H

AU - Pless, P

AU - Nielsen, J R

AU - Møller, M

PY - 1992/11/1

Y1 - 1992/11/1

N2 - In a consecutive series of 123 men (aged 55 +/- 8 years) with a recent first acute myocardial infarction (AMI), 24-hour ambulatory ST-segment monitoring was performed early after discharge (day 11 +/- 5), 6 months (day 185 +/- 6) and 1 year (day 368 +/- 8) after AMI. No difference in the prevalence of transient myocardial ischemia was found between the 3 recordings (17, 17 and 20%), and most ischemic episodes were silent (98, 100 and 97%). In the early postinfarction period, a peak of ischemic activity was demonstrated between 6 P.M. and midnight (40 of 93 episodes [43%]). Over time, the maximal occurrence of ischemia gradually advanced toward the morning hours with a peak activity between 6 A.M. and noon at 1-year follow-up (32 of 73 episodes [44%]). Significantly more patients (16 of 21 [76%]) had ischemia from 6 P.M. to midnight at discharge compared with the findings 1 year later (9 of 23 patients [39%]) (p < 0.03). An opposite trend was found regarding patients who exhibited ischemic episodes in the hours from 6 A.M. to noon: 10 of 21 patients (48%) early after discharge versus 17 of 23 patients (74%) at 1-year follow-up (p = not significant). Results from the 6-month recording displayed characteristics between the findings from discharge and 1-year ambulatory monitoring. The pathophysiologic processes underlying the observations from this study are unknown. The change in circadian periodicity could not be explained from differences in heart rate variation patterns or medical antianginal treatment among the 3 recordings.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - In a consecutive series of 123 men (aged 55 +/- 8 years) with a recent first acute myocardial infarction (AMI), 24-hour ambulatory ST-segment monitoring was performed early after discharge (day 11 +/- 5), 6 months (day 185 +/- 6) and 1 year (day 368 +/- 8) after AMI. No difference in the prevalence of transient myocardial ischemia was found between the 3 recordings (17, 17 and 20%), and most ischemic episodes were silent (98, 100 and 97%). In the early postinfarction period, a peak of ischemic activity was demonstrated between 6 P.M. and midnight (40 of 93 episodes [43%]). Over time, the maximal occurrence of ischemia gradually advanced toward the morning hours with a peak activity between 6 A.M. and noon at 1-year follow-up (32 of 73 episodes [44%]). Significantly more patients (16 of 21 [76%]) had ischemia from 6 P.M. to midnight at discharge compared with the findings 1 year later (9 of 23 patients [39%]) (p < 0.03). An opposite trend was found regarding patients who exhibited ischemic episodes in the hours from 6 A.M. to noon: 10 of 21 patients (48%) early after discharge versus 17 of 23 patients (74%) at 1-year follow-up (p = not significant). Results from the 6-month recording displayed characteristics between the findings from discharge and 1-year ambulatory monitoring. The pathophysiologic processes underlying the observations from this study are unknown. The change in circadian periodicity could not be explained from differences in heart rate variation patterns or medical antianginal treatment among the 3 recordings.(ABSTRACT TRUNCATED AT 250 WORDS)

KW - Chi-Square Distribution

KW - Circadian Rhythm

KW - Electrocardiography, Ambulatory

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Myocardial Ischemia

KW - Prospective Studies

KW - Time Factors

M3 - Journal article

VL - 70

SP - 1117

EP - 1122

JO - The American Journal of Cardiology

JF - The American Journal of Cardiology

SN - 0002-9149

IS - 13

ER -