Changes to the septo-fornical area might play a role in the pathogenesis of anxiety in multiple sclerosis

Miklos Palotai, Andrea Mike, Michele Cavallari, Erzsebet Strammer, Gergely Orsi, Brian C Healy, Katharina Schregel, Zsolt Illes, Charles Rg Guttmann

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

BACKGROUND: Reports on the relationships between white matter lesion load (WMLL) and fatigue and anxiety in multiple sclerosis (MS) are inconsistent.

OBJECTIVE: To investigate the association of total and tract-specific WMLL with fatigue and anxiety.

METHODS: Total and regional T2 WMLL was assessed for 19 tracts in 48 MS patients (30 females). ICBM-DTI-81 Atlas-based parcellation was combined with WMLL segmentation of T2-weighted magnetic resonance imaging (MRI). Fatigue, anxiety, and depression were assessed using Fatigue Impact Scale, State Trait Anxiety Inventory, and Beck Depression Inventory, respectively.

RESULTS: Fatigue, anxiety, and depression showed significant inter-correlation. We found no association between fatigue and total or regional WMLLs, whereas anxiety was associated with total and regional WMLLs in nine tracts. After adjusting for total WMLL, age, and depression, only the column and body of the fornix (CBF) remained significantly associated with anxiety. Post hoc analyses showed no CBF lesions on T1-weighted MRI and suggested, but could not confirm, that the septum pellucidum might play a role in the pathogenesis of anxiety.

CONCLUSION: Our results suggest that anxiety in MS patients may have a neuropathological substrate in the septo-fornical area, which requires further validation using larger sample size and ultra-high-field MRI in targeted prospective studies.

OriginalsprogEngelsk
TidsskriftMultiple Sclerosis Journal
Vol/bind24
Udgave nummer8
Sider (fra-til)1105-1114
ISSN1352-4585
DOI
StatusUdgivet - jul. 2018

Fingeraftryk

Dyk ned i forskningsemnerne om 'Changes to the septo-fornical area might play a role in the pathogenesis of anxiety in multiple sclerosis'. Sammen danner de et unikt fingeraftryk.

Citationsformater