Changes in the use of glucose-lowering drugs: A Danish nationwide study

Anton Pottegard, Jacob H. Andersen, Jens Sondergaard, Reimar W. Thomsen, Tina Vilsboll

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Aim: To investigate changes in the pattern of drugs used to treat type 2 diabetes in Denmark from 2005 to 2021. Materials and Methods: A nationwide, population-based drug utilization study based on medical databases covering the Danish population was conducted. We assessed incident and prevalent use patterns among all 441 205 individuals initiating at least one non-insulin, glucose-lowering drug. Results: The rate of new users of non-insulin, glucose-lowering drugs increased from 2005, peaked in 2011, decreased to stable levels during 2013 to 2019, then increased dramatically during 2020-2021. The prevalence of use increased from 2.1in 2005) to 5.0in 2021) of the entire adult population. In 2021, metformin comprised 39lowering drug consumption, followed by insulin (17, sodium-glucose co-transporter-2 inhibitors (SGLT-2is) (17, glucagon-like peptide-1 receptor agonists (GLP-1RAs) (16 and dipeptidyl peptidase-4 inhibitors (7.5. Overall, 56 28 while 13.8 respectively. Both the intensity and diversity of therapies increased substantially over time, with 15 different treatment regimens each covering more than 1021. General practitioners prescribed 88lowering drugs. Marked shifts towards GLP-1RA initiation by general practitioners and SGLT-2i initiation by specialists were observed, and changing user profiles suggested increasing use for non-diabetes indications. Conclusions: The rate of new users of non-insulin, glucose-lowering drugs has increased in recent years and the prevalence of glucose-lowering drug use increases steadily. Glucose-lowering drugs are mainly prescribed by general practitioners, and the intensity, diversity and indications of glucose-lowering treatment are increasing.
TidsskriftDiabetes, Obesity and Metabolism
Udgave nummer4
Sider (fra-til)1002-1010
StatusUdgivet - apr. 2023