Changes in left ventricular filling patterns after repeated injection of autologous bone marrow cells in heart failure patients

Axel Cosmus Pyndt Diederichsen, Jacob E Møller, Per Thayssen, Lars Videbæk, Susanne G Sækmose, Torben Barington, Moustapha Kassem

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2010-Mar-17
OriginalsprogEngelsk
TidsskriftScandinavian Cardiovascular Journal
Vol/bind44
Udgave nummer3
Sider (fra-til)139-145
ISSN1401-7431
DOI
StatusUdgivet - 17. mar. 2010

Fingeraftryk

Plasma Volume
Brain Natriuretic Peptide
Outcome Assessment (Health Care)

Citer dette

@article{8c08c240576211df937d000ea68e967b,
title = "Changes in left ventricular filling patterns after repeated injection of autologous bone marrow cells in heart failure patients",
abstract = "Abstract Objectives. We have previously shown that repeated intracoronary infusion of bone marrow cells (BMSC) did not improve left ventricular (LV) ejection fraction in patients with chronic ischemic heart failure. However, the impact of BMSC therapy on LV diastolic filling has remained uncertain. Design. Thirty two patients with LV ejection fraction less than 40{\%} were studied. Each patient underwent three baseline echocardiograms to ensure stable LV filling. Infusion of BMSC was given at baseline and again after four months. Echocardiograms were repeated four, eight and 12 months after the first intervention. Main outcome measures were the ratio of transmitral flow (E) velocity to early mitral annulus (e') velocity (E/e'), left atrial (LA) volume and plasma levels of N-terminal pro-brain natriuretic peptide (NT- pro-BNP). Results. During the initial observational period there were no changes in main outcome. After treatment with intracoronary BMSC a significant decrease was observed in E/e' ratio (14.7+/-6.7 vs. 13.2+/-7.7, p=0.04), LA volume (90+/-25 ml vs. 80+/-26 ml, p=0.006) and plasma NT-pro-BNP (p=0.03). The effect was greatest in patients who received the largest amount of CD34(+) cells. Conclusion. In this non-randomised study repeated intracoronary BMSC infusions had a beneficial effect on LV filling in patients with chronic ischemic heart failure. Randomised studies are warranted.",
author = "Diederichsen, {Axel Cosmus Pyndt} and M{\o}ller, {Jacob E} and Per Thayssen and Lars Videb{\ae}k and S{\ae}kmose, {Susanne G} and Torben Barington and Moustapha Kassem",
year = "2010",
month = "3",
day = "17",
doi = "10.3109/14017430903556294",
language = "English",
volume = "44",
pages = "139--145",
journal = "Scandinavian Cardiovascular Journal",
issn = "1401-7431",
publisher = "Taylor & Francis",
number = "3",

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Changes in left ventricular filling patterns after repeated injection of autologous bone marrow cells in heart failure patients. / Diederichsen, Axel Cosmus Pyndt; Møller, Jacob E; Thayssen, Per; Videbæk, Lars; Sækmose, Susanne G; Barington, Torben; Kassem, Moustapha.

I: Scandinavian Cardiovascular Journal, Bind 44, Nr. 3, 17.03.2010, s. 139-145.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Changes in left ventricular filling patterns after repeated injection of autologous bone marrow cells in heart failure patients

AU - Diederichsen, Axel Cosmus Pyndt

AU - Møller, Jacob E

AU - Thayssen, Per

AU - Videbæk, Lars

AU - Sækmose, Susanne G

AU - Barington, Torben

AU - Kassem, Moustapha

PY - 2010/3/17

Y1 - 2010/3/17

N2 - Abstract Objectives. We have previously shown that repeated intracoronary infusion of bone marrow cells (BMSC) did not improve left ventricular (LV) ejection fraction in patients with chronic ischemic heart failure. However, the impact of BMSC therapy on LV diastolic filling has remained uncertain. Design. Thirty two patients with LV ejection fraction less than 40% were studied. Each patient underwent three baseline echocardiograms to ensure stable LV filling. Infusion of BMSC was given at baseline and again after four months. Echocardiograms were repeated four, eight and 12 months after the first intervention. Main outcome measures were the ratio of transmitral flow (E) velocity to early mitral annulus (e') velocity (E/e'), left atrial (LA) volume and plasma levels of N-terminal pro-brain natriuretic peptide (NT- pro-BNP). Results. During the initial observational period there were no changes in main outcome. After treatment with intracoronary BMSC a significant decrease was observed in E/e' ratio (14.7+/-6.7 vs. 13.2+/-7.7, p=0.04), LA volume (90+/-25 ml vs. 80+/-26 ml, p=0.006) and plasma NT-pro-BNP (p=0.03). The effect was greatest in patients who received the largest amount of CD34(+) cells. Conclusion. In this non-randomised study repeated intracoronary BMSC infusions had a beneficial effect on LV filling in patients with chronic ischemic heart failure. Randomised studies are warranted.

AB - Abstract Objectives. We have previously shown that repeated intracoronary infusion of bone marrow cells (BMSC) did not improve left ventricular (LV) ejection fraction in patients with chronic ischemic heart failure. However, the impact of BMSC therapy on LV diastolic filling has remained uncertain. Design. Thirty two patients with LV ejection fraction less than 40% were studied. Each patient underwent three baseline echocardiograms to ensure stable LV filling. Infusion of BMSC was given at baseline and again after four months. Echocardiograms were repeated four, eight and 12 months after the first intervention. Main outcome measures were the ratio of transmitral flow (E) velocity to early mitral annulus (e') velocity (E/e'), left atrial (LA) volume and plasma levels of N-terminal pro-brain natriuretic peptide (NT- pro-BNP). Results. During the initial observational period there were no changes in main outcome. After treatment with intracoronary BMSC a significant decrease was observed in E/e' ratio (14.7+/-6.7 vs. 13.2+/-7.7, p=0.04), LA volume (90+/-25 ml vs. 80+/-26 ml, p=0.006) and plasma NT-pro-BNP (p=0.03). The effect was greatest in patients who received the largest amount of CD34(+) cells. Conclusion. In this non-randomised study repeated intracoronary BMSC infusions had a beneficial effect on LV filling in patients with chronic ischemic heart failure. Randomised studies are warranted.

U2 - 10.3109/14017430903556294

DO - 10.3109/14017430903556294

M3 - Journal article

C2 - 20233136

VL - 44

SP - 139

EP - 145

JO - Scandinavian Cardiovascular Journal

JF - Scandinavian Cardiovascular Journal

SN - 1401-7431

IS - 3

ER -